Protecting Groups
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Greene S Protective Groups In Organic Synthesis
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Author : Peter G. M. Wuts
language : en
Publisher: John Wiley & Sons
Release Date : 2012-12-20
Greene S Protective Groups In Organic Synthesis written by Peter G. M. Wuts and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-20 with Science categories.
The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
Protecting Groups
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Author : Philip J. Kocienski
language : en
Publisher: Thieme
Release Date : 2005
Protecting Groups written by Philip J. Kocienski and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Organic compounds categories.
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.
Greene S Protective Groups In Organic Synthesis
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Author : Peter G. M. Wuts
language : en
Publisher: John Wiley & Sons
Release Date : 2014-08-08
Greene S Protective Groups In Organic Synthesis written by Peter G. M. Wuts and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-08 with Science categories.
An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene’s as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology. • Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching • Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner • Adds over 2800 new references to update since thepublication of the last edition • Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)
Protective Groups In Organic Chemistry
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Author : J. McOmie
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Protective Groups In Organic Chemistry written by J. McOmie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Protecting Group Free Organic Synthesis
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Author : Rodney A. Fernandes
language : en
Publisher: John Wiley & Sons
Release Date : 2018-08-20
Protecting Group Free Organic Synthesis written by Rodney A. Fernandes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-20 with Science categories.
Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.
Protective Groups In Organic Synthesis
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Author : Theodora W. Greene
language : en
Publisher:
Release Date : 1981-05-14
Protective Groups In Organic Synthesis written by Theodora W. Greene and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-05-14 with Science categories.
Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.
Protecting Groups Strategies And Applications In Carbohydrate Chemistry
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Author : Sebastien Vidal
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-29
Protecting Groups Strategies And Applications In Carbohydrate Chemistry written by Sebastien Vidal and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Science categories.
A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.
Activating Agents And Protecting Groups
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Author : Anthony J. Pearson
language : en
Publisher: John Wiley & Sons
Release Date : 1999-07-09
Activating Agents And Protecting Groups written by Anthony J. Pearson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-09 with Science categories.
Aus dem bestehenden Material der "Encyclopedia of Reagents for Organic Synthesis" (EROS) werden Paquette und die Herausgeber 500 bevorzugte Reagenzien auswählen, die dann in 4 Bände entsprechend ihrer Klassifikation eingeteilt werden, z.B. Oxidations- und Reduktionsreagenzien. Die endgültigen Titel der Bände werden festgelegt, sobald die Auswahl der 500 Reagenzien vorgenommen wurde. Jeder Band wird sich in Umfang und Struktur an EROS orientieren, d.h. er verfügt über eine Einleitung, die ausgewählten Reagenzien erscheinen in alphabetischer Reihenfolge, und es gibt jeweils einen Index zu Reagenzien, Autoren und Themenkomplexen. Für jedes Reagenz werden die physikalischen und chemischen Daten detailliert angegeben, so daß der Leser den Gebrauch der jeweiligen Reagenz versteht und sicher mit ihr arbeiten kann. (01/99)
Protecting Groups In Organic Synthesis
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Author : James R. Hanson
language : en
Publisher: Wiley-Blackwell
Release Date : 1999-11-15
Protecting Groups In Organic Synthesis written by James R. Hanson and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-15 with Science categories.
This volume provides, at postgraduate student level, an accessible introduction to a topic of central importance in organic synthesis. It covers the main functional groups requiring protection in organic synthesis, explaining why a particular protecting agent works and how an agent should be chosen. Emphasis is placed on what a protecting group is doing chemically to the structure that it is protecting. Attention is given to removal of the protecting group. This is a clear and thoughtful book, which concentrates on explaining the chemistry. It also provides a convenient point of entry to the primary literature.
Elements Of Synthesis Planning
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Author : R. W. Hoffmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-01-07
Elements Of Synthesis Planning written by R. W. Hoffmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-07 with Science categories.
Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.