Protective Groups In Organic Synthesis
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Greene S Protective Groups In Organic Synthesis
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Author : Peter G. M. Wuts
language : en
Publisher: John Wiley & Sons
Release Date : 2014-08-08
Greene S Protective Groups In Organic Synthesis written by Peter G. M. Wuts and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-08 with Science categories.
An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene’s as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology. • Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching • Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner • Adds over 2800 new references to update since thepublication of the last edition • Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)
Protective Groups In Organic Synthesis
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Author : Theodora W. Greene
language : en
Publisher:
Release Date : 1981-05-14
Protective Groups In Organic Synthesis written by Theodora W. Greene and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-05-14 with Science categories.
Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.
Protective Groups In Organic Chemistry
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Author : J. McOmie
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Protective Groups In Organic Chemistry written by J. McOmie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Protecting Groups
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Author : Philip J. Kocienski
language : en
Publisher: Thieme
Release Date : 2005
Protecting Groups written by Philip J. Kocienski and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Organic compounds categories.
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.
Protective Groups In Organic Synthesis
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Author : Theodora W. Greene
language : en
Publisher: Wiley-Interscience
Release Date : 1991-05-16
Protective Groups In Organic Synthesis written by Theodora W. Greene and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-16 with Science categories.
Contains 206 new groups and 1,500 new references, representing full coverage of the literature from 1980 to 1989. In addition, two new sections on the protection for indoles, imidazoles and pyrroles, and protection for the amide -NH are included. Most of the original material from the first edition has been retained, including the indispensable Reactivity Charts.
Protective Groups In Organic Chemistry
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Author : John Frederick William McOmie
language : en
Publisher: Springer
Release Date : 1973
Protective Groups In Organic Chemistry written by John Frederick William McOmie and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Science categories.
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Protecting Groups In Organic Synthesis
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Author : James Ralph Hanson
language : en
Publisher: Blackwell Science Incorporated
Release Date : 1999-01-01
Protecting Groups In Organic Synthesis written by James Ralph Hanson and has been published by Blackwell Science Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Science categories.
Protecting Group Free Organic Synthesis
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Author : Rodney A. Fernandes
language : en
Publisher: John Wiley & Sons
Release Date : 2018-08-20
Protecting Group Free Organic Synthesis written by Rodney A. Fernandes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-20 with Science categories.
Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.
Protecting Groups In Organic Synthesis
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Author : James Ralph Hanson
language : en
Publisher:
Release Date : 1999
Protecting Groups In Organic Synthesis written by James Ralph Hanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Organic compounds categories.
Elements Of Synthesis Planning
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Author : R. W. Hoffmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-01-07
Elements Of Synthesis Planning written by R. W. Hoffmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-07 with Science categories.
Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.