Protein Folding
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Protein Folding
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Author : Charis Ghelis
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Protein Folding written by Charis Ghelis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Protein Folding aims to collect the most important information in the field of protein folding and probes the main principles that govern formation of the three-dimensional structure of a protein from a nascent polypeptide chain, as well as how the functional properties appear. This text is organized into three sections and consists of 15 chapters. After an introductory chapter where the main problems of protein folding are considered at the cellular level in the context of protein biosynthesis, the discussion turns to the conformation of native globular proteins. Definitions and rules of nomenclature are given, including the structural organization of globular proteins deduced from X-ray crystallographic data. Folding mechanisms are tentatively deduced from the observation of invariants in the architecture of folded proteins. The next chapters focus on the energetics of protein conformation and structure, indicating the principles of thermodynamic stability of the native structure, along with theoretical computation studies of protein folding, structure prediction, and folding simulation. The reader is also introduced to various experimental approaches; the reversibility of the unfolding-folding process; equilibrium and kinetic studies; and detection and characterization of intermediates in protein folding. This text concludes with a chapter dealing with problems specific to oligomeric proteins. This book is intended for research scientists, specialists, biochemists, and students of biochemistry and biology.
Protein Folding
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Author : Cláudio M. Gomes
language : en
Publisher: Springer
Release Date : 2019-02-25
Protein Folding written by Cláudio M. Gomes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-25 with Science categories.
This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.
Protein Folding
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Author : Tony R. Obalinsky
language : en
Publisher: Nova Publishers
Release Date : 2006
Protein Folding written by Tony R. Obalinsky and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Protein folding categories.
Proteins are one of the most basic components of all living cells and therefore serve a vital purpose in the cells of animals, plants and bacteria. They are comprised of chains of amino acids, which are held together by ribosome. These chains have many different patterns, which are known as `folds.' These folds are complicated, and therefore susceptible to irregularities that are known to be the source of many diseases. Cystic fibrosis, mad cow disease, Alzheimer's disease, emphysema and others are all initiated by improper protein folds. It is clear that, improving our understanding of protein folding is a key to fighting these diseases. This book presents recently performed research from around the world on this important subject.
Protein Folding
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Author : C. M. Dobson
language : en
Publisher: Cambridge University Press
Release Date : 1995
Protein Folding written by C. M. Dobson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Discusses the molecular mechanisms controlling protein folding in vivo and in vitro.
Protein Folding Misfolding And Aggregation
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Author : Victor Muñoz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Protein Folding Misfolding And Aggregation written by Victor Muñoz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods h.
Protein Folding
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Author : Alka Dwevedi
language : en
Publisher: Springer
Release Date : 2014-12-01
Protein Folding written by Alka Dwevedi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Science categories.
The book will discuss classes of proteins and their folding, as well as the involvement of bioinformatics in solving the protein folding problem. In vivo and in vitro folding mechanisms are examined, as well as the failures of in vitro folding, a mechanism helpful in understanding disease caused by misfolding. The role of energy landscapes is also discussed and the computational approaches to these landscapes.
Protein Folding Evolution And Design
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Author : Eugene I. Shakhnovich
language : en
Publisher: IOS Press
Release Date : 2001
Protein Folding Evolution And Design written by Eugene I. Shakhnovich and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
This text presents the results of broad, interdisciplinary effort to study proteins in physical and evolutionary perpective. Among authors are physicists, computational, chemists, crystallographers and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented, providing a broad picture of modern biophysical chemistry.
The Protein Folding Problem
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Author : Donald B Wetlaufer
language : en
Publisher: Routledge
Release Date : 2019-06-21
The Protein Folding Problem written by Donald B Wetlaufer and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-21 with Social Science categories.
Proteins in living systems carry out a great variety of specific functions, each of which depends on the precise three-dimensional structure of a particular protein. Proteins are synthesized in the form of a flexible polypeptide chain that is capable of assuming a vast number of configurations; the transformation of this chain into a specific, relatively rigid three-dimensional structure is called folding--a remarkable process of self-organization. It is known that the amino acid sequences of some proteins have sufficient information to determine their three-dimensional structures. There are other proteins whose folding requires additional information beyond that found in the sequence of the mature protein. This book introduces the central problem of folding mechanisms as well as a number of other closely related issues. This book is neither a textbook nor a treatise. Rather, it is an attempt by several investigators to convey the excitement and challenges of those aspects of the folding problem in which they are actively engaged. The contributors give brief introductions to protein folding from the perspectives of molecular architecture, stability and dynamics, phage genetics, DNA exons, general physiology, and natural selection. They point out emerging new directions, including the suggestion of a class of diseases that result from protein folding defects.
The Protein Folding Problem And Tertiary Structure Prediction
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Author : Kenneth M.Jr. Merz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Protein Folding Problem And Tertiary Structure Prediction written by Kenneth M.Jr. Merz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.
Protein Folding Protocols
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Author : Yawen Bai
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Protein Folding Protocols written by Yawen Bai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
Covering experiment and theory, bioinformatics approaches, and state-of-the-art simulation protocols for better sampling of the conformational space, this volume describes a broad range of techniques to study, predict, and analyze the protein folding process. Protein Folding Protocols also provides sample approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences.