Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry
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Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry
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Author : Ganglong Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-14
Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry written by Ganglong Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-14 with Science categories.
Mass Spectrometry
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Author : Anshul Pandey
language : en
Publisher: Educohack Press
Release Date : 2025-02-20
Mass Spectrometry written by Anshul Pandey and has been published by Educohack Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-20 with Science categories.
"Mass Spectrometry: Techniques and Applications" is a comprehensive guide to understanding and mastering the principles, techniques, and applications of this powerful analytical method. We cover a wide range of topics, delving into the intricacies of ionization methods, mass analyzers, ion detection, and data analysis strategies crucial for accurate and reliable mass spectrometry results. We explore the fundamentals of mass spectrometry, including ionization and fragmentation principles, isotopic patterns, and mass-to-charge ratio calculations. Various ionization techniques such as electrospray ionization (ESI), matrix-assisted laser desorption/ionization (MALDI), and electron ionization (EI) are elucidated, providing insights into their mechanisms and applications. Advanced topics like tandem mass spectrometry (MS/MS), high-resolution mass spectrometry (HRMS), and ion mobility spectrometry (IMS) are also covered, offering a comprehensive understanding of cutting-edge techniques and instrumentation. Practical aspects of mass spectrometry, including method development, calibration strategies, data interpretation, and troubleshooting, are detailed to help researchers, students, and professionals navigate experiments effectively. Additionally, we showcase the diverse applications of mass spectrometry across fields such as pharmaceuticals, environmental analysis, metabolomics, proteomics, forensics, and materials science. Case studies, real-world examples, and emerging trends provide valuable insights into the role of mass spectrometry in advancing scientific discovery and addressing societal challenges. With clear explanations, illustrative diagrams, and practical tips, "Mass Spectrometry: Techniques and Applications" serves as an indispensable resource for anyone seeking a comprehensive and up-to-date reference on this essential analytical technique.
Text Book Of Modern Pharmaceutical Analytical Techniques
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Author : Dr. Amit Semwal, Dr. Renu Solanki, Dr. Noel Rahul Shaw, Dr. Prashant Kumar Desai, Dr. Narendra Kumar Nyola
language : en
Publisher: Shashwat Publication
Release Date : 2025-06-06
Text Book Of Modern Pharmaceutical Analytical Techniques written by Dr. Amit Semwal, Dr. Renu Solanki, Dr. Noel Rahul Shaw, Dr. Prashant Kumar Desai, Dr. Narendra Kumar Nyola and has been published by Shashwat Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-06 with Medical categories.
The "Textbook of Modern Pharmaceutical Analytical Techniques" provides a comprehensive and methodical understanding of various analytical tools crucial for pharmaceutical research and quality control. It begins with fundamental spectroscopic methods such as UV-Visible and IR spectroscopy, detailing their theory, instrumentation, solvent effects, and practical applications in pharmaceutical analysis. The book progresses to advanced techniques like NMR and Mass Spectroscopy, offering insights into their principles, structural elucidation capabilities, and technical aspects like ionization methods and analyzers. Spectrofluorimetry and atomic techniques such as Flame Emission and Atomic Absorption Spectroscopy are thoroughly discussed, including their instrumentation and interferences. A major highlight is the detailed section on Chromatography, covering a wide array of techniques—paper, TLC, ion exchange, column, gas, HPLC, and affinity chromatography—along with their principles, resolution factors, and pharmaceutical applications. The textbook also includes Electrophoresis methods, explaining paper, gel, capillary, and iso-electric focusing techniques, each with working conditions and analytical significance. The chapter on X-ray Crystallography provides foundational knowledge on crystal structures, Bragg’s law, and diffraction techniques essential for drug molecule characterization. Finally, it explores Immunological assays like RIA, ELISA, and bioluminescence assays, underscoring their critical role in diagnostic and therapeutic monitoring. This book is not only a valuable academic resource for pharmacy and analytical chemistry students but also serves as a practical guide for laboratory professionals involved in pharmaceutical quality assurance and research. Through clear explanations and structured content, it bridges theoretical concepts with real-world analytical challenges in the pharmaceutical industry.
Text Book Of Modern Pharmaceutical Analytical Techniques
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Author : Kritika Sachan, Rudra Prasad Adhikari, Dr. Gaurav Deep Singh, Dr. Sushama Rawat, Dr Pichika Mallikarjuna Rao
language : en
Publisher: Shashwat Publication
Release Date : 2025-05-30
Text Book Of Modern Pharmaceutical Analytical Techniques written by Kritika Sachan, Rudra Prasad Adhikari, Dr. Gaurav Deep Singh, Dr. Sushama Rawat, Dr Pichika Mallikarjuna Rao and has been published by Shashwat Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Fiction categories.
The Textbook of Modern Pharmaceutical Analytical Techniques provides a comprehensive overview of contemporary methods used in the analysis of pharmaceutical substances. Beginning with UV-Visible spectroscopy, it covers the fundamental theories, instrumentation, solvent effects, and its wide range of applications. IR spectroscopy follows, explaining molecular vibrations, sample handling, instrumentation like FTIR, and practical applications. Spectrofluorimetry introduces the principles of fluorescence, factors affecting it, and the role of quenchers, with a detailed look at fluorescence spectrophotometers. Flame emission spectroscopy and Atomic absorption spectroscopy chapters delve into their respective principles, instrumentation, interferences, and uses in detecting metal ions. NMR spectroscopy is explored in depth, highlighting quantum numbers, chemical shift factors, spin-spin coupling, and advanced concepts like FT-NMR and 13C NMR. Mass spectrometry is extensively covered, including various ionization techniques (such as MALDI and ESI), fragmentation patterns, and the use of analyzers like Quadrupole and TOF. A thorough section on Chromatography discusses different types from paper and TLC to HPLC and affinity chromatography, explaining principles, equipment, and factors affecting resolution. Electrophoresis chapters describe multiple types including capillary and isoelectric focusing, emphasizing the working conditions and their applications. The book also features an insightful chapter on X-ray Crystallography, discussing X-ray production, diffraction methods, Bragg’s law, and various crystal types. Finally, the text covers Immunological assays such as RIA, ELISA, and bioluminescence techniques, crucial for pharmaceutical and biomedical research. The book carefully integrates theoretical concepts with instrumental details, making it a valuable resource for students, researchers, and professionals in the field of pharmaceutical sciences. With a strong focus on practical applications, it bridges the gap between academic knowledge and industry needs. Each chapter is structured to first explain basic concepts and then delve into technical aspects, ensuring clarity at every level. Instrumentation diagrams, solvent choices, analytical parameters, and troubleshooting strategies are consistently highlighted. Special emphasis is placed on factors influencing experimental outcomes, enhancing readers' problem-solving skills. Case studies and real-world examples add richness to the academic content. The book supports the development of analytical thinking and laboratory expertise. It also discusses the regulatory relevance of various analytical methods in pharmaceutical quality control. Overall, the Textbook of Modern Pharmaceutical Analytical Techniques stands out as a detailed, accessible, and up-to-date guide for mastering modern pharmaceutical analysis. Its systematic and lucid approach empowers readers to both understand and apply analytical techniques efficiently. Whether for coursework, exam preparation, or professional reference, it serves as a reliable and comprehensive textbook. It is an essential addition to the library of anyone pursuing a career in pharmaceutical analysis.
Mass Spectrometry In The Biological Sciences A Tutorial
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Author : M.L Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mass Spectrometry In The Biological Sciences A Tutorial written by M.L Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection.
The Art Of Carbohydrate Analysis
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Author : Gerrit J. Gerwig
language : en
Publisher: Springer Nature
Release Date : 2021-10-23
The Art Of Carbohydrate Analysis written by Gerrit J. Gerwig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-23 with Medical categories.
The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
Biotechnology Molecular Biology And Genetic Engineering Of Plants
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-03-24
Biotechnology Molecular Biology And Genetic Engineering Of Plants written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-24 with Science categories.
Covers plant biotechnology, molecular biology, and genetic engineering. Focuses on gene manipulation, crop improvement, and biotechnological applications in agriculture.
Unravelling Cancer Signaling Pathways A Multidisciplinary Approach
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Author : Kakoli Bose
language : en
Publisher: Springer Nature
Release Date : 2019-11-25
Unravelling Cancer Signaling Pathways A Multidisciplinary Approach written by Kakoli Bose and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with Medical categories.
Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.
Structural Biology In Drug Discovery
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Author : Jean-Paul Renaud
language : en
Publisher: John Wiley & Sons
Release Date : 2020-01-27
Structural Biology In Drug Discovery written by Jean-Paul Renaud and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-27 with Medical categories.
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Annual Plant Reviews Plant Proteomics
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Author : Christine Finnie
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Annual Plant Reviews Plant Proteomics written by Christine Finnie and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Science categories.
The proteome comprises all protein species resulting from geneexpression in a cell, organelle, tissue or organism. By definition,proteomics aims to identify and characterise the expressionpattern, cellular location, activity, regulation,post-translational modifications, molecular interactions, threedimensional structures and functions of each protein in abiological system. In plant science, the number of proteome studies is rapidlyexpanding after the completion of the Arabidopsis thaliana genomesequence, and proteome analyses of other important or emergingmodel systems and crop plants are in progress or are beinginitiated. Proteome analysis in plants is subject to the sameobstacles and limitations as in other organisms, but the nature ofplant tissues, with their rigid cell walls and complex variety ofsecondary metabolites, means that extra challenges are involvedthat may not be faced when analysing other organisms. This volume aims to highlight the ways in which proteome analysishas been used to probe the complexities of plant biochemistry andphysiology. It is aimed at researchers in plant biochemistry,genomics, transcriptomics and metabolomics who wish to gain anup-to-date insight into plant proteomes, the information plantproteomics can yield and the directions plant proteome research istaking.