Protein Misfolding
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Protein Misfolding And Disease
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Author : Peter Bross
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Protein Misfolding And Disease written by Peter Bross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.
Protein Misfolding Aggregation And Conformational Diseases
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Author : Vladimir N. Uversky
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-24
Protein Misfolding Aggregation And Conformational Diseases written by Vladimir N. Uversky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-24 with Science categories.
Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
Protein Misfolding
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Author : Rossen Donev
language : en
Publisher: Academic Press
Release Date : 2020-01-13
Protein Misfolding written by Rossen Donev and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-13 with Science categories.
Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more. Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disorders Contains timely chapters written by well-renowned authorities in their field Provides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students
Protein Misfolding Diseases
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Author : Marina Ramirez-Alvarado
language : en
Publisher: John Wiley & Sons
Release Date : 2010-12-01
Protein Misfolding Diseases written by Marina Ramirez-Alvarado and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Science categories.
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Protein Folding Misfolding And Disease
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Author : Andrew F. Hill
language : en
Publisher: Humana Press
Release Date : 2011-07-01
Protein Folding Misfolding And Disease written by Andrew F. Hill and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-01 with Science categories.
Protein misfolding is a key feature of many disorders in humans, given that over twenty proteins are known to misfold and cause disease. In Protein Folding, Misfolding, and Disease: Methods and Protocols, experts in the field present a collection of current methods for studying the analysis of protein folding and misfolding, featuring strategies for expressing and refolding recombinant proteins which can then be utilized in subsequent experiments. This detailed volume also covers methods for analyzing the formation of amyloid, protocols for determining the size and structure of native and misfolded proteins, as well as specific examples of where misfolded proteins can be examined using state-of –the-art technologies. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Up to date and authoritative, Protein Folding, Misfolding, and Disease: Methods and Protocols offers researchers the tools necessary to move ahead in this vital field.
Protein Misfolding In Neurodegenerative Diseases
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Author : Robert D. E. Sewell
language : en
Publisher: CRC Press
Release Date : 2007-12-03
Protein Misfolding In Neurodegenerative Diseases written by Robert D. E. Sewell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-03 with Medical categories.
Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.
Protein Folding Misfolding And Aggregation
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Author : Victor Muñoz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Protein Folding Misfolding And Aggregation written by Victor Muñoz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods h.
Misbehaving Proteins
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Author : Regina Murphy
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-12
Misbehaving Proteins written by Regina Murphy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-12 with Science categories.
This text provides an up-to-date collection of theoretical and experimental studies into protein folding, misfolding, aggregation, and stability. Additionally, issues faced during the development of protein products are illustrated. It contains an introductory chapter for readers new to the protein folding field. The book provides a thorough and clear discussion of computational approaches to understanding and modeling protein aggregation.
Protein Misfolding
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Author : Cian B. O'Doherty
language : en
Publisher:
Release Date : 2008
Protein Misfolding written by Cian B. O'Doherty and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Amyloid categories.
Proteins occasionally exhibit the potential to adopt alternate folds under natural or artificial conditions. These conformational changes can lead to the creation of disease-forming amyloid plaques or accumulation of insoluble aggregates in over-expressed recombinant proteins. Because alternate folds challenge the traditional notion of structurally defined proteins and frequently lead to problems in natural and laboratory settings, it is tempting to characterise structurally ambiguous proteins as ill-behaved. Unfortunately, this perspective masks the positive role structural ambiguity can play in protein function and evolution. This book provides leading-edge research on the study of protein misfolding from researchers all over the globe.
Protein Folding
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Author : Tony R. Obalinsky
language : en
Publisher: Nova Publishers
Release Date : 2006
Protein Folding written by Tony R. Obalinsky and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Protein folding categories.
Proteins are one of the most basic components of all living cells and therefore serve a vital purpose in the cells of animals, plants and bacteria. They are comprised of chains of amino acids, which are held together by ribosome. These chains have many different patterns, which are known as `folds.' These folds are complicated, and therefore susceptible to irregularities that are known to be the source of many diseases. Cystic fibrosis, mad cow disease, Alzheimer's disease, emphysema and others are all initiated by improper protein folds. It is clear that, improving our understanding of protein folding is a key to fighting these diseases. This book presents recently performed research from around the world on this important subject.