Protein Modifications In Epigenetic Dysfunctional Diseases Mechanisms And Potential Therapeutic Strategies
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Protein Modifications In Epigenetic Dysfunctional Diseases Mechanisms And Potential Therapeutic Strategies
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Author : Bin Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-01
Protein Modifications In Epigenetic Dysfunctional Diseases Mechanisms And Potential Therapeutic Strategies written by Bin Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-01 with Science categories.
Medicinal Plants For The Management Of Neurodegenerative Diseases
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Author : Jamal Akhtar
language : en
Publisher: CRC Press
Release Date : 2024-06-17
Medicinal Plants For The Management Of Neurodegenerative Diseases written by Jamal Akhtar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-17 with Science categories.
Ageing is the main reason for most neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). About 10% of individuals aged ≥65 years develop AD, which continuously increases with growing age. Medicinal plants have been used for age-related neurodegenerative disorders for a long time. These plants are rich in terms of various phytochemical constituents such as flavonoids, sterols, alkaloids, saponins, and terpenoids. Different scientific studies have been carried out on these medicinal herbs, e.g., anti-inflammatory, antioxidant, and neuro-regenerative activities that may be used in the treatment of AD and other age-related diseases. These medicinal plants, e.g., Curcuma longa, Bacopa monniera, Glycyrrhiza glabra, Commiphora whighitti, and Acorus calamus L., have anti-inflammatory properties that may decrease swelling of the brain tissue in AD. Despite this, there is currently no book available in the market that provides full information on the phytochemical and medicinal uses of the medicinal plants exclusively used for the management of neurodegenerative diseases in the elderly. This book aims to provide some important and evidence-based information on the plants used for neurodegenerative diseases in the elderly, especially AD and PD, in a planned manner so the academicians, researchers, and students working in the fields of medicinal plants, plant science, chemistry, biotechnology, pharmacognosy, pharmaceuticals, biochemistry, and many other interdisciplinary subjects may benefit. This book will also be useful in identifying a few medicinal plants and their prospects for the synthesis or preparation of new drugs for neurodegenerative diseases. Features: · An overview of the medicinal plants that can be helpful for neurodegenerative disorders. · Recent research results and some pointers for the management of neurodegenerative diseases. This book serve as comprehensive information about the description, phytochemistry, actions, and medicinal use of plants that are used in neurodegenerative diseases. In addition, this book will also ease the understanding and interaction of medicinal plants used in neurodegenerative diseases.
Epigenetic Regulation Of Autophagy In Inflammatory Diseases
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Author : Kai Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-13
Epigenetic Regulation Of Autophagy In Inflammatory Diseases written by Kai Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-13 with Medical categories.
Epigenetics refers to changes in the expression of heritable genes or cellular phenotypes caused by regulating DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, without altering the DNA sequence. It plays a critical role in the regulation of many physiological and pathological processes, such as inflammation, immunity, and tumor. In particular, many epigenetic modifiers have been found to affect innate cell development, infection, and inflammatory responses by regulating gene-specific expression. Epigenetic abnormalities often result in changes in gene expression and its function, which in turn promote the process of inflammation and even tumorigenesis. Autophagy is a highly conserved subcellular degradation process by which some damaged organelles, misfolded proteins, nucleic acids, and pathogenic microorganisms are digested to maintain homeostasis. Autophagy dysregulation has been implicated in multiple diseases, including inflammation, tumors, and neurodegenerative diseases. It is not only a cytoplasmic event, but also involved in the regulation of nuclear components, including histone modifications, microRNA, and transcription factors. Methyltransferase-mediated histone modifications (H3K9me2, H3R17me2, and H3K27me3), miRNAs, and DNA methylation catalyzed by DNA methyltransferase are the key nuclear factors involved in the regulation of autophagy. In addition, some autophagy-related genes (Atgs) promote or inhibit the autophagic process through epigenetic modifications, such as histone modifications and DNA methylation, affecting the occurrence and development of inflammatory diseases. Studying the role of epigenetic regulation of autophagy in inflammatory diseases may help identify novel drug targets and develop potential diagnostic and therapeutic approaches. Although the biological and clinical significance of epigenetic modification of autophagy has attracted more and more attention from researchers, this regulation is very complex and its role and mechanism in inflammatory diseases are still unclear.
Protein Homeostasis In Growth Development And Disease
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Author : Francesco Fazi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-08
Protein Homeostasis In Growth Development And Disease written by Francesco Fazi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-08 with Science categories.
Mitochondrial Dysfunction In Aging And Diseases Of Aging
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Author : Richard H. Haas
language : en
Publisher: MDPI
Release Date : 2019-10-01
Mitochondrial Dysfunction In Aging And Diseases Of Aging written by Richard H. Haas and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
Neuronal Mechanisms Of Epileptogenesis
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Author : Roberto Di Maio
language : en
Publisher: Frontiers E-books
Release Date : 2015-01-13
Neuronal Mechanisms Of Epileptogenesis written by Roberto Di Maio and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Brain categories.
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments
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Author : Mariela Fernanda Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments written by Mariela Fernanda Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Neuroprotective Effects Of Phytochemicals In Brain Ageing
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Author : Surajit Pathak
language : en
Publisher: Springer Nature
Release Date : 2024-06-05
Neuroprotective Effects Of Phytochemicals In Brain Ageing written by Surajit Pathak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-05 with Science categories.
This book discusses the mechanism and therapeutic strategies of phytochemicals against brain ageing. It discusses the underlying anti-oxidative and anti-inflammatory mechanisms of the phytochemicals and the implications of these compounds in the prevention and treatment of geriatric diseases. It discusses the potential role of the highly complex interactive network between the gut and the brain in neurodegenerative diseases such as Parkinson’s disease (PD), and Alzheimer’s disease. The chapters provide insight into the mechanisms involved in brain ageing and the mechanism of actions of the phytochemicals that might be crucial in developing effective new therapies against brain ageing. The chapter also presents the mechanisms of action of phytoconstituents, bioavailabilities, and their effects on neuroinflammation. The chapters also examine the phytochemicals protection of neurons via targeting oxidative stress, mitochondrial dysfunction, neurotrophic factor deficit, apoptosis, and abnormal protein accumulation. This book aims to provide comprehensive and cutting-edge information on the potential neuroprotective role of phytochemicals on the brain and neurological disorders to researchers, neuroscientists, clinical nutritionists, and physicians.
Molecular And Cellular Mechanisms Of Heart Failure Pathophysiology Pathogenesis And Therapeutics
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Author : Kenneth Scott Campbell
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-06
Molecular And Cellular Mechanisms Of Heart Failure Pathophysiology Pathogenesis And Therapeutics written by Kenneth Scott Campbell and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-06 with Medical categories.
Psychological Support By Cognitive Behavioral Therapy For Phenylketonuria Pku
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date :
Psychological Support By Cognitive Behavioral Therapy For Phenylketonuria Pku written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on with Psychology categories.
Phenylketonuria (PKU) is a rare but impactful metabolic condition that profoundly affects those diagnosed, as well as their families and support systems. Living with PKU presents both medical and psychological challenges, often leading to feelings of isolation, stress, and anxiety about the future. Managing the lifelong dietary restrictions and the uncertainties that come with a genetic disorder can be overwhelming, especially when compounded by societal pressures, stigma, and the complexities of medical care. This book, Psychological Support by Cognitive Behavioral Therapy for Phenylketonuria (PKU), aims to bridge the gap between the medical management of PKU and the psychological support that is crucial for living a fulfilling life with the condition. While medical treatment focuses on controlling phenylalanine levels, this book addresses the emotional, psychological, and cognitive challenges that often go unspoken but deeply affect quality of life. Drawing on Cognitive Behavioral Therapy (CBT)—a proven approach to managing various psychological issues—this book provides tools, strategies, and insights specifically tailored to individuals with PKU. It is designed to help patients, caregivers, and healthcare professionals navigate the psychological impact of PKU, offering ways to manage stress, anxiety, trauma, and the myriad of emotional challenges that arise from living with a chronic genetic condition. We start by exploring the biology of PKU and providing foundational knowledge on genetics, epigenetics, and hereditary diseases. From there, the focus shifts to the psychological aspects, diving deep into how trauma, anxiety, and stress can influence the mental well-being of those with PKU. The latter sections of the book are dedicated to practical applications of CBT, offering a range of tools and techniques designed to empower individuals in managing their emotions, improving mental health, and maintaining a balanced, healthy outlook on life. It is my hope that this book will provide comfort, understanding, and practical support to those living with PKU. By integrating the science of genetics with the art of psychological therapy, we can begin to build a more holistic approach to care—one that nurtures both body and mind. I sincerely hope this book becomes a valuable resource for individuals and families affected by PKU, as well as for healthcare providers seeking to offer more comprehensive support to their patients.