Protein Toxins In Modeling Biochemistry

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Protein Toxins In Modeling Biochemistry

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Author : Raj Kumar
language : en
Publisher: Springer
Release Date : 2016-11-21

Protein Toxins In Modeling Biochemistry written by Raj Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Science categories.

This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein toxicity. This concise and yet thorough text also discusses using toxin structure as a model for studying structural and functional aspects of protein chemistry. Protein Toxins in Modeling Biochemistry, a SpringerBrief, is essential reading for advanced researchers, scientists and advanced graduate students interested in protein chemistry and related areas of biochemistry and molecular science.

Bacterial Protein Toxins

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Author : K. Aktories
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14

Bacterial Protein Toxins written by K. Aktories and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Guidebook To Protein Toxins And Their Use In Cell Biology

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Author : Rino Rappuoli
language : en
Publisher: OUP Oxford
Release Date : 1997-05-29

Guidebook To Protein Toxins And Their Use In Cell Biology written by Rino Rappuoli and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-29 with Medical categories.

Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

Protein Toxin Structure

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Author : Michael W. Parker
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Protein Toxin Structure written by Michael W. Parker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

Joseph E. Alouf "The empirical basis of objective science has thus nothing 'abso lute' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen dous development of this field of biological sciences, particularly in the past decade.

The Comprehensive Sourcebook Of Bacterial Protein Toxins

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Author : Joseph E. Alouf
language : en
Publisher: Academic Press
Release Date : 2015-05-29

The Comprehensive Sourcebook Of Bacterial Protein Toxins written by Joseph E. Alouf and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-29 with Science categories.

The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins

Pore Forming Peptides And Protein Toxins

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Author : Gianfranco Menestrina
language : en
Publisher: CRC Press
Release Date : 2003-01-30

Pore Forming Peptides And Protein Toxins written by Gianfranco Menestrina and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-30 with Medical categories.

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, venomous attack, and innate immunity. Pore-forming Peptides and Protein Toxins describes how natural and synthetic peptides and toxins form pores and ionic channels that cause cell membrane collapse and cell death. Written by researchers from around the world, it discusses such topics as the channel-forming properties of Helicobacter pylori and the role of amyloid peptide channels in the development of amyloid diseases. This text provides a multidisciplinary approach to understanding the basic principles and cellular mechanisms of the actions of toxins and their potential use as research tools.

Handbook Of Natural Toxins Volume 8

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Author : Joel Moss
language : en
Publisher: CRC Press
Release Date : 1995-03-21

Handbook Of Natural Toxins Volume 8 written by Joel Moss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-21 with Medical categories.

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria

G Proteins And Calcium Signaling

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Author : Paul H. Naccache
language : en
Publisher: CRC Press
Release Date : 1989-10-31

G Proteins And Calcium Signaling written by Paul H. Naccache and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-10-31 with Medical categories.

Calcium Signaling provides a review of the salient points of knowledge relating G proteins to calcium mobilization in a variety of cells including blood cells, (e.g. platelets, neutrophils, lymphocytes) liver, pancreas, cardiac tissue, pituitary cells, olfactory cilia, photoreceptors and the major elements of the transmembrane transduction processes is an important addition to the libraries of biological chemists, cell biologists, physiologists, pharmacologists and biophysicists among others.

Microbial Toxins And Diarrhoeal Disease

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Author : David Evered
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-14

Microbial Toxins And Diarrhoeal Disease written by David Evered and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-14 with Medical categories.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Biodefense Research Methodology And Animal Models

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Author : James R. Swearengen
language : en
Publisher: CRC Press
Release Date : 2012-02-16

Biodefense Research Methodology And Animal Models written by James R. Swearengen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-16 with Medical categories.

Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA's Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Resea