Protein Tyrosine Phosphatases In Breast Cancer
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Protein Tyrosine Phosphatases In Cancer
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Author : Benjamin G. Neel
language : en
Publisher: Springer
Release Date : 2016-08-05
Protein Tyrosine Phosphatases In Cancer written by Benjamin G. Neel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-05 with Medical categories.
This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
Protein Tyrosine Phosphatases In Breast Cancer
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Author : Mairin Rafferty
language : en
Publisher:
Release Date : 2002
Protein Tyrosine Phosphatases In Breast Cancer written by Mairin Rafferty and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The Role Of Protein Tyrosine Phosphatases In Breast Cancer
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Author : Christina Holzer
language : en
Publisher:
Release Date : 2009
The Role Of Protein Tyrosine Phosphatases In Breast Cancer written by Christina Holzer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Cell Adhesion Linked Protein Tyrosine Phosphatases And Breast Cancer Metastasis
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Author :
language : en
Publisher:
Release Date : 2004
Cell Adhesion Linked Protein Tyrosine Phosphatases And Breast Cancer Metastasis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
21 "classical" protein tyrosine phosphatases (PTPs) were identified in human mammary epithelial cell (MEC) lines. Degenerate RT-PCR followed by restriction fragment differential display (RFDD) and specific RT-PCR were used to assess expression in the continuous HMT-3522 cell series that includes both non-malignant Si and tumorigenic T4-2 cells in monolayer and during normal and dysregulated morphogenesis in EHS-ECM (Matrigel). PTP expression was generally higher in tumorigenic T4-2 cells and unchanged by disorganized growth in Matigel. in contrast, coordination of expression was suggested by the transient upregulation (relative to monolayer cultures) of a number of PTPs during acinar morphogenesis of non-malignant Si. The kinetics of downregulation for some suggested that growth arrest may be the main regulatory input. Others however, downregulate with more rapid kinetics before significant growth arrest suggesting different regulatory inputs. Feedback from of cell-cell adherens junctions (AJ) may be one such input as ectopic expression of a dominant negative E-cadherin construct that blocks AJ formation delayed but did not prevent downregulation of selected PTPs. Modest upregulation of actin cytoskeleton regulating PTPs in response to decreases in substrate compliancy occur when normal MCF10A were plated on (1 order of magnitude) softer (tissue-like) Matrigel coupled polyacrylamide gels suggesting that these PTPs may be responding to, or mediating corresponding actin cytoskeletal reaorganization. PTPN12 is a cytoplasmic PTP highly expressed in MECs that localizes transiently to actin polymerizing zones including lamellopodial leading edges and the metaphase mitotic spindle and plasma membrane. Stable downregulation of PTPN12 by retroviral mediated shRNAi resulted in derangements of the actin cytoskeleton in MCF10A cells. These cells grew more rapidly and formed larger but normally polarized acini in Matrigel.
Characterization Of Protein Tyrosine Phosphatases In Human Breast Epithelial Cells Neoplastically Transformed By The Neu Oncogene
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Author : Yifan Zhai
language : en
Publisher:
Release Date : 1993
Characterization Of Protein Tyrosine Phosphatases In Human Breast Epithelial Cells Neoplastically Transformed By The Neu Oncogene written by Yifan Zhai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Breast categories.
Adhesion Linked Protein Tyrosine Phosphatases Morphogenesis And Breast Cancer Progression
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Author :
language : en
Publisher:
Release Date : 2004
Adhesion Linked Protein Tyrosine Phosphatases Morphogenesis And Breast Cancer Progression written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Stromal-epithelial interactions regulate mammary epithelial cell (MEC) fate via integrin-growth factor receptor (GFR) interactions. Integrin-GFR crosstalk influences MEC behavior through activation of tyrosine kinase signaling that is tempered by protein tyrosine phosphatase (PTP) activity of which we know little about. Using a degenerate RT-PCR to amplify PTPs expressed in differentiated versus non-differentiated MECs, we identified the Band 4.1 PTPs MEG1 and Dl as two candidate PTP metastasis suppressors. Our studies show that during MEC differentiation PTP MEGl and Dl expression rise dramatically, coincident with assembly of E-cadherin/Beta-catenin adherens junction formation. However, both mRNA and protein expression of MEGl and Dl become repressed following MEC tissue differentiation. Because we could not establish any correlation between MEC growth, or tissue polarization, this suggests that MEG1 and Dl expression may be functionally linked to adherens junction assembly. Consistently, malignant MECs that fail to assemble adherens junctions do not modulate MEGl or Dl expression. Moreover, MEGl expression is not induced in phenotypically reverting tumors, or down regulated in dormant structures. This suggests that these Band 4.1 PTPs may be functionally-linked to molecules mediating adherens junction formation.
Opposing Roles For Protein Tyrosine Phosphatases Shp2 And Ptpn12 In Breast Cancer
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Author : Nicola Aceto
language : en
Publisher:
Release Date : 2011
Opposing Roles For Protein Tyrosine Phosphatases Shp2 And Ptpn12 In Breast Cancer written by Nicola Aceto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Involvement Of Tyrosine Phosphatases In Insulin Signaling And Apoptosis In Breast Cancer
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Author :
language : en
Publisher:
Release Date : 2002
Involvement Of Tyrosine Phosphatases In Insulin Signaling And Apoptosis In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Our preliminary studies demonstrated that increased intracellular calcium activates calpain to induce partial proteolysis and cytoplasmic translocation of PTP1B, a tyrosine phosphatase proposed to regulate signaling by insulin, IGF-1 and other cytokines. Cytoplasmic translocation of PTP1B results in a distinct pattern of protein tyrosine phosphorylation and these events may regulate cell growth or apoptosis by reducing activated growth factor signaling. In this scheme, calcium-mediated apoptosis and growth inhibition may be directed through mobilization of PTP1B.
Protein Tyrosine Phosphatases In Human Breast Cancer Cell
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Author : Universitat de València. Facultat de Ciències Biològiques
language : en
Publisher:
Release Date : 2011
Protein Tyrosine Phosphatases In Human Breast Cancer Cell written by Universitat de València. Facultat de Ciències Biològiques and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The Receptor Tyrosine Kinase Met And The Protein Tyrosinephosphatase Ptpn2 In Breast Cancer
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Author : Cynthia Veenstra
language : en
Publisher:
Release Date : 2017
The Receptor Tyrosine Kinase Met And The Protein Tyrosinephosphatase Ptpn2 In Breast Cancer written by Cynthia Veenstra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.