Proteinases As Drug Targets
DOWNLOAD
Download Proteinases As Drug Targets PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Proteinases As Drug Targets book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Proteinases As Drug Targets
DOWNLOAD
Author : Ben Dunn
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011-11-22
Proteinases As Drug Targets written by Ben Dunn and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-22 with Science categories.
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.
Proteinase And Peptidase Inhibition
DOWNLOAD
Author : H. John Smith
language : en
Publisher: CRC Press
Release Date : 2002-03-28
Proteinase And Peptidase Inhibition written by H. John Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-28 with Medical categories.
Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the
Proteases As Drug Targets
DOWNLOAD
Author : Joseph P. Vacca
language : en
Publisher: Wiley-VCH
Release Date : 2010-06-29
Proteases As Drug Targets written by Joseph P. Vacca and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-29 with Science categories.
Part of a suite of three similarly organized books on proteases, the family of serine proteases is described from a drug developer's perspective. This book also contains numerous case studies from recently developed protease drugs.
Proteases As Targets For Therapy
DOWNLOAD
Author : Klaus von der Helm
language : en
Publisher: Springer Science & Business Media
Release Date : 2000
Proteases As Targets For Therapy written by Klaus von der Helm and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Protease inhibitors categories.
This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.
Proteases As Drug Targets
DOWNLOAD
Author : Joseph P. Vacca
language : en
Publisher: Wiley-VCH
Release Date : 2010-06-29
Proteases As Drug Targets written by Joseph P. Vacca and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-29 with Science categories.
This first-ever guide to protease inhibitor drug design ties together the knowledge gained from numerous recent protease drugs in a single source. Edited by one of the most prominent protease drug developers in the pharmaceutical industry, it describes the family of metalloproteases from a drug developer's perspective.
Cancer Leading Proteases
DOWNLOAD
Author : Satya Prakash Gupta
language : en
Publisher: Academic Press
Release Date : 2020-01-09
Cancer Leading Proteases written by Satya Prakash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-09 with Business & Economics categories.
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples
Proteases Of Infectious Agents
DOWNLOAD
Author : Ben Dunn
language : en
Publisher: Elsevier
Release Date : 1999-07-01
Proteases Of Infectious Agents written by Ben Dunn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-01 with Science categories.
Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Includes information on the basic biology and function of proteases Provides global survey of current research efforts in protease inhibitors Illustrates how structure-based drug design targets effective and selective compounds Highlights important diseases that provide economically important targets Describes the role of proteases as important new targets for drug discovery
Proteases From Basic Structure To Function To Drug Design As Targeted Therapy
DOWNLOAD
Author : Hang Fai Kwok
language : en
Publisher: Mdpi AG
Release Date : 2021-12-27
Proteases From Basic Structure To Function To Drug Design As Targeted Therapy written by Hang Fai Kwok and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-27 with Science categories.
In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartosová-Sojková et al. 2021).
Enzymes As Targets For Drug Design
DOWNLOAD
Author : Michael Palfreyman
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Enzymes As Targets For Drug Design written by Michael Palfreyman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.
Proteases In Physiology And Pathology
DOWNLOAD
Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2017-09-14
Proteases In Physiology And Pathology written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.