Proteases As Drug Targets
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Proteases As Drug Targets
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Author : Joseph P. Vacca
language : en
Publisher: Wiley-VCH
Release Date : 2010-06-29
Proteases As Drug Targets written by Joseph P. Vacca and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-29 with Science categories.
Part of a suite of three similarly organized books on proteases, the family of serine proteases is described from a drug developer's perspective. This book also contains numerous case studies from recently developed protease drugs.
Proteases As Drug Targets
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Author : Joseph P. Vacca
language : en
Publisher: Wiley-VCH
Release Date : 2010-06-29
Proteases As Drug Targets written by Joseph P. Vacca and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-29 with Science categories.
This first-ever guide to protease inhibitor drug design ties together the knowledge gained from numerous recent protease drugs in a single source. Edited by one of the most prominent protease drug developers in the pharmaceutical industry, it describes the family of metalloproteases from a drug developer's perspective.
Proteinases As Drug Targets
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Author : Ben Dunn
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011-11-22
Proteinases As Drug Targets written by Ben Dunn and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-22 with Science categories.
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.
Proteinase And Peptidase Inhibition
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Author : H. John Smith
language : en
Publisher: CRC Press
Release Date : 2002-03-28
Proteinase And Peptidase Inhibition written by H. John Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-28 with Medical categories.
Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the
Proteases From Basic Structure To Function To Drug Design As Targeted Therapy
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Author : Hang Fai Kwok
language : en
Publisher: Mdpi AG
Release Date : 2021-12-27
Proteases From Basic Structure To Function To Drug Design As Targeted Therapy written by Hang Fai Kwok and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-27 with Science categories.
In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibition strategies are one of the fastest expanding areas in the field of of drugs that show considerable promise. This Special Issue will focus on the recent advances in the discovery and development of protease inhibitors, covering the synthesis of protease inhibitors, the design of new chemical entities acting as inhibitors of special/particular types of proteases, and their mode of actions (Frolova et al. 2020; Slapak et al. 2020; Künnapuu et al. 2021). In addition, the new applications of these interesting compounds/biomolecules and their limitations have been discussed and described (Wang et al. 2020; Bartosová-Sojková et al. 2021).
Proteases As Targets For Therapy
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Author : Klaus, von der Helm
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Proteases As Targets For Therapy written by Klaus, von der Helm and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With contributions by numerous experts
Viral Proteases As Drug Targets And The Mechanisms Of Drug Resistance
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Author : Kuan-Hung Lin
language : en
Publisher:
Release Date : 2016
Viral Proteases As Drug Targets And The Mechanisms Of Drug Resistance written by Kuan-Hung Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Cancer Leading Proteases
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Author : Satya Prakash Gupta
language : en
Publisher: Academic Press
Release Date : 2020-01-09
Cancer Leading Proteases written by Satya Prakash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-09 with Business & Economics categories.
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples
Proteases In Health And Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-04
Proteases In Health And Disease written by Sajal Chakraborti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-04 with Science categories.
In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Proteases In Physiology And Pathology
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2017-09-14
Proteases In Physiology And Pathology written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.