Proteases In Physiology And Pathology
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Proteases In Physiology And Pathology
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2017-09-14
Proteases In Physiology And Pathology written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
Aspartic Proteinases Physiology And Pathology
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Author : Martin Fusek
language : en
Publisher: CRC Press
Release Date : 2019-10-10
Aspartic Proteinases Physiology And Pathology written by Martin Fusek and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-10 with Medical categories.
Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.
Proteases In Health And Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-04
Proteases In Health And Disease written by Sajal Chakraborti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-04 with Science categories.
In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Proteases Ii
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Author : Walter H. Hörl
language : en
Publisher: Springer
Release Date : 1988
Proteases Ii written by Walter H. Hörl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
The Proceedings of the Second International symposium "Proteases: Potential Role in Health and Disease" which was held in Rothenburg ob der Tauber (FRG) during May 17-20, 1987. The topics discussed those dealing with the physiology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-Kinin, complement and coagulation system, the function of proteases in arthritis, malignoma, Pancreatitis, intestinal tract, lung and kidney disease as well in hypercatabolic states (acute renal failure, multiple trauma and septicemia). Furthermore some reports dealed with the role of proteases during extracorporeal circulation. The paper presented answered many questions, but reised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortiunately impossible in this volume, to include the extended, lively and stimulating discussions which were enjoyed by the participiants during the conference. The meeting has provided a unique framework for close interaction between scientists from various disciplines, including molecular biology, biology, biochemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pneumatology and nephrology.
Proteases In Gastrointestinal Tissues
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Author : Uwe Lendeckel
language : en
Publisher: Springer
Release Date : 2010-11-16
Proteases In Gastrointestinal Tissues written by Uwe Lendeckel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Medical categories.
This book is unique for its comprehensive presentation of protease function in the stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Animal models and experimental data are discussed in the context of patient-derived data.
Proteases Protease Inhibitors And Protease Derived Peptides
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Author : J. Cheronis
language : en
Publisher: Birkhäuser
Release Date : 1993-06-01
Proteases Protease Inhibitors And Protease Derived Peptides written by J. Cheronis and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-01 with Science categories.
This volume focuses on the importance of proteases, protease inhibitors and protease-derived peptides in human pathophysiology. The papers present an overview of the actions of proteases in normal and pathological conditions. These include: the interactions of proteases and naturally occurring and/or exogenously administered antiproteases in both mild and severe inflammatory conditions; the importance of uncontrolled proteolytic activities and organ system damage; the interaction of protease-derived peptides and their antagonists in the potential treatment of a number of pathophysiologic conditions; and the potential that antiprotease therapies may have in new therapeutic strategies.
Proteases In Human Diseases
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2017-07-13
Proteases In Human Diseases written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-13 with Medical categories.
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Proteases Protease Inhibitors And Protease Derived Peptides
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Author : J. Cheronis
language : en
Publisher: Birkhäuser
Release Date : 1993-06-01
Proteases Protease Inhibitors And Protease Derived Peptides written by J. Cheronis and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-01 with Science categories.
Matrix Metalloproteinase Inhibitors
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Author : Satya Prakash Gupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-05
Matrix Metalloproteinase Inhibitors written by Satya Prakash Gupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-05 with Medical categories.
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
Matrix Metalloproteinases In Health And Disease Sculpting The Human Body
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Author : Constance E Brinckerhoff
language : en
Publisher: World Scientific
Release Date : 2017-05-05
Matrix Metalloproteinases In Health And Disease Sculpting The Human Body written by Constance E Brinckerhoff and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-05 with Science categories.
The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.