Proteomics For Biomarker Discovery
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Proteomics For Biomarker Discovery
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Author : Ming Zhou
language : en
Publisher: Humana
Release Date : 2016-08-23
Proteomics For Biomarker Discovery written by Ming Zhou and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
With the advent of proteomics came the development of technologies, primarily mass spectrometry, which allowed high-throughput identification of proteins in complex mixtures. While the mass spectrometer resides at the heart of proteomics, its ability to characterize biological samples is only as good as the sample preparation and data analysis tools used in any study. In Proteomics for Biomarker Discovery, expert researchers in the field detail many of the methods which are now commonly used to study proteomics. These include methods and techniques include both label-free approaches and those that utilize stable isotopes incorporated both during cell growth or added via a chemical reaction once the proteome is extracted from the cell. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Proteomics for Biomarker Discovery seeks to aid scientists in the further study the different sample preparation and data analysis tools used in proteomics today.
Proteomics For Biomarker Discovery
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Author : Virginie Brun
language : en
Publisher:
Release Date : 2019
Proteomics For Biomarker Discovery written by Virginie Brun and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biochemical markers categories.
Proteomics For Biomarker Discovery
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Author : Virginie Brun
language : en
Publisher: Humana Press
Release Date : 2019-05-04
Proteomics For Biomarker Discovery written by Virginie Brun and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-04 with Science categories.
This volume presents modern and enhanced methods that detail techniques to perform proteomics analyses dedicated to biomarker discovery for human health. Chapters guide readers through pre/post analytical factors, protocols for the preparation of extracellular vesicles and exosomes, and various analytical pipelines including Data Independent Acquisition (DIA), discovery, as well as targeted and top-down proteomics analysis workflows. Bioinformatics tools and workflows to select and evaluate candidate biomarkers or combinations of biomarkers are also presented. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Proteomics for Biomarker Discovery: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Biomarker Discovery In The Developing World Dissecting The Pipeline For Meeting The Challenges
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Author : Sanjeeva Srivastava
language : en
Publisher: Springer
Release Date : 2016-09-30
Biomarker Discovery In The Developing World Dissecting The Pipeline For Meeting The Challenges written by Sanjeeva Srivastava and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-30 with Medical categories.
This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from “cell to society” in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world.
Proteomic And Metabolomic Approaches To Biomarker Discovery
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Author : Haleem J. Issaq
language : en
Publisher: Academic Press
Release Date : 2013-05-20
Proteomic And Metabolomic Approaches To Biomarker Discovery written by Haleem J. Issaq and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-20 with Science categories.
Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research. Describes the use of biomarkers to reduce clinical errors in research Includes techniques from a range of biomarker discoveries Covers all steps involved in biomarker discovery, from study design to study execution
Proteomic And Metabolomic Approaches To Biomarker Discovery
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Author : Haleem J. Issaq
language : en
Publisher: Academic Press
Release Date : 2019-10-24
Proteomic And Metabolomic Approaches To Biomarker Discovery written by Haleem J. Issaq and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Science categories.
Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students
Comprehensive Biomarker Discovery And Validation For Clinical Application
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Author : Péter Horvatovich
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Comprehensive Biomarker Discovery And Validation For Clinical Application written by Péter Horvatovich and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This book covers proteomics biomarker discovery and validation procedures from the clinical perspective.
Tissue Proteomics
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Author : Brian Liu
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-31
Tissue Proteomics written by Brian Liu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-31 with Science categories.
In one volume this book provides useful and innovative protocols developed specifically for the proteomic profiling of human tissues. The book provides high-throughput gel-based techniques, microarrays and a number of other methods used in proteomic research. This important book will prove indispensable to investigators of biomarker discovery and therapeutic response profiling, as well as those forging new paths in the fields of theranostics and personalized medicine.
Proteomics For Biological Discovery
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Author : Timothy D. Veenstra
language : en
Publisher: John Wiley & Sons
Release Date : 2006-06-12
Proteomics For Biological Discovery written by Timothy D. Veenstra and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-12 with Science categories.
Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.
Proteomic Strategy For Cancer Biomarker Discovery
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Author : Ralph Schiess
language : de
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release Date : 2009
Proteomic Strategy For Cancer Biomarker Discovery written by Ralph Schiess and has been published by Sudwestdeutscher Verlag Fur Hochschulschriften AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Worldwide over 25 million people have cancer and more than 10 million die from it each year. There is a growing focus on cancer diagnosis because accurate and timely detection of the disease means a better chance for patient survival and lower treatment costs. Today's diagnostic screening methods are often inadequate due to their low accuracy. So far, the high complexity of blood prohibited the sensitive and high throughput profiling of patient sample sets large enough to reliably detect cancer-indicating differences. Yet despite intensive interest and investment, only a few cancer biomarkers are used in clinical practice. This book will give you an overview of the establishment of a new strategy for the discovery, verification and validation of cancer protein biomarkers. Thereby different technological and biological aspects are discussed. Finally, the preliminary results of a prostate cancer study, which resulted in the identification of a panel of new protein biomarker superior to the current standard PSA (prostate specific antigen), are shown.