Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses
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Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses
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Author : Yong Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses written by Yong Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-storing molecule, but may also reach the extracellular space, where it participates in cell-to-cell signalling. For this purpose, ATP utilises a range of purinergic receptors activated either by ATP itself (P2X receptors; seven subtypes) or by ATP/ADP and UTP/UDP (P2Y receptors; 8 subtypes) and finally via its enzymatic degradation product, adenosine (P1/A receptors; 4 subtypes). Purine nucleotides and nucleosides together with the whole plethora of receptors and degrading enzymes constitute the purinome. This fascinating and extensive network exists both in the animal kingdom and in humans and is essential in regulating important physiological functions. Disturbances in the network can lead to a variety of illnesses clinically associated with both neurological or psychiatric traits. In recent years, hope has arisen that pharmacological chemistry together with various newly developed methods, will enable researchers to discover and design efficient drugs for treating these neurodegenerative and affective diseases.
Purinergic Signalling And The Nervous System
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Author : Geoffrey Burnstock
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-05
Purinergic Signalling And The Nervous System written by Geoffrey Burnstock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Medical categories.
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Purinergic Signalling And The Nervous System
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Author : Geoffrey Burnstock
language : en
Publisher: Springer
Release Date : 2012-06-05
Purinergic Signalling And The Nervous System written by Geoffrey Burnstock and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Medical categories.
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Adenosine Receptors In Health And Disease
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Author : Constance N. Wilson
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-28
Adenosine Receptors In Health And Disease written by Constance N. Wilson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-28 with Medical categories.
Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
Adenosinergic System And Central Nervous System Disorders
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Author : Francisney Pinto Nascimento
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-17
Adenosinergic System And Central Nervous System Disorders written by Francisney Pinto Nascimento and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-17 with Science categories.
Purinergic Pharmacology
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Author : Francisco Ciruela
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Purinergic Pharmacology written by Francisco Ciruela and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Receptors P1 And P2 As Targets For Drug Therapy In Humans
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Author : Robson Faria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Receptors P1 And P2 As Targets For Drug Therapy In Humans written by Robson Faria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Purinergic Signaling In Health And Disease
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Author : Eric Boué-Grabot
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-13
Purinergic Signaling In Health And Disease written by Eric Boué-Grabot and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with categories.
P2x7 As Common Therapeutic Target In Brain Diseases
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Author : Tobias Engel
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-29
P2x7 As Common Therapeutic Target In Brain Diseases written by Tobias Engel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.
Manic Depressive Insanity And Paranoia
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Author : Emil Kraepelin
language : en
Publisher: Lushena Books
Release Date : 2023-07-14
Manic Depressive Insanity And Paranoia written by Emil Kraepelin and has been published by Lushena Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-14 with Psychology categories.
The latter part Of the book is devoted to an account Of Paranoia, which title is' employed in the narrowest sense and is restricted in application to those forms, which are very Often described as true or non-hallucinatory Paranoia. The more numerous allied and hallucinatory forms are mainly grouped by Kraepelin under the title Paraphrenia, though some may be included under Paranoid Dementia Praecox, to which dis order its relationship is undoubtedly very close. Further, it may be added that as true Paranoia has also affinities to some varieties Of Mania, all these forms Of insanity seem to merge into one another at their SO - called boundaries or limits, as do the colours Of the spectrum, though the fully developed and typical forms are as distinct from one another and as recognisable as the primary colours. The medical profession is under a debt Of gratitude to Dr Mary Barclay for her faithful rendering into English of these classical studies. She has now completed the translation Of Professor Kraepelin's careful descriptions Of those forms Of mental disorder which are commonly known as The Psychoses, namely, Dementia Praecox, Paraphrenia, manic-depressive Insanity, and Paranoia. These disorders form a definite group and provide the most effective illustrations Of Professor Kraepelin's accurate methods Of analysing and investigating mental disease. His orderly descriptions will be found Of great value to the medical Officers Of our mental hospitals, and to all engaged in the study Of clinical psychiatry, particularly to those reading for a Diploma in Psychological Medicine.