Purinergic Pharmacology
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Purinergic Pharmacology
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Author : Francisco Ciruela
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Purinergic Pharmacology written by Francisco Ciruela and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Purinergic Pharmacology Volume Ii
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Author : Francisco Ciruela
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-07
Purinergic Pharmacology Volume Ii written by Francisco Ciruela and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-07 with Science categories.
Purinergic Approaches In Experimental Therapeutics
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Author : Kenneth A. Jacobson
language : en
Publisher: Wiley-Liss
Release Date : 1997-07-15
Purinergic Approaches In Experimental Therapeutics written by Kenneth A. Jacobson and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-15 with Medical categories.
Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellularhomeostasis and disease etiology have come to be understoodgradually over the past 40 years. However, due to the recentcloning and expression of receptors for ATP and adenosine, novelcompounds have been developed with unique therapeutic potential forthe treatment of thrombosis, stroke, epilepsy, chronic pain,immunological disorders, and cancer. As a result, the study ofadenosine- and ATP-mediated responses in cellular regulation isentering a phase of opportunity and development unmatched since thedays of serotonin receptor research in the 1970s. The only definitive book on the topic, Purinergic Approaches inExperimental Therapeutics covers all of the major therapeuticapplications of purinergic receptors and reflects the very latestdevelopments in this new area of therapeutic research. Twenty-eightchapters, authored by an international group of contributors whoare the leading authorities in the field, provide details onmolecular pharmacology; medicinal chemistry; and therapeuticimplications, including cardiology, metabolism, immunology,neurology, and cancer. Among the topics covered: * Purinergic Neurotransmission and Neuromodulation: A HistoricalPerspective * Adenosine Receptor Subtypes: New Insights from Cloning andFunctional Studies * Modulators of Adenosine Uptake, Release, and Inactivation * Cardiac Electrophysiology of Adenosine: Antiarrhythmic andProarrhythmic Actions * Purinergic Modulation of Gastrointestinal Function * The Role of Adenosine in Asthma * ATP in Brain Function * ATP in the Treatment of Cancer For researchers in pharmacology, physiology, molecular biology, andmedicinal chemistry, Purinergic Approaches in ExperimentalTherapeutics heralds an exciting new era in the understanding ofpurinergic neurotransmission and the development of noveltherapeutic modalities.
Purinergic And Pyrimidinergic Signalling
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Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-12
Purinergic And Pyrimidinergic Signalling written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-12 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Pharmacology Of Purine And Pyrimidine Receptors
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Author : Kenneth A Jacobson
language : en
Publisher: Academic Press
Release Date : 2011-06
Pharmacology Of Purine And Pyrimidine Receptors written by Kenneth A Jacobson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06 with Medical categories.
This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development
Purinergic And Pyrimidinergic Signalling Ii
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Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purinergic And Pyrimidinergic Signalling Ii written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club
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Author : Francesco Caciagli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club written by Francesco Caciagli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses
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Author : Yong Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses written by Yong Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-storing molecule, but may also reach the extracellular space, where it participates in cell-to-cell signalling. For this purpose, ATP utilises a range of purinergic receptors activated either by ATP itself (P2X receptors; seven subtypes) or by ATP/ADP and UTP/UDP (P2Y receptors; 8 subtypes) and finally via its enzymatic degradation product, adenosine (P1/A receptors; 4 subtypes). Purine nucleotides and nucleosides together with the whole plethora of receptors and degrading enzymes constitute the purinome. This fascinating and extensive network exists both in the animal kingdom and in humans and is essential in regulating important physiological functions. Disturbances in the network can lead to a variety of illnesses clinically associated with both neurological or psychiatric traits. In recent years, hope has arisen that pharmacological chemistry together with various newly developed methods, will enable researchers to discover and design efficient drugs for treating these neurodegenerative and affective diseases.
Receptors P1 And P2 As Targets For Drug Therapy In Humans
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Author : Robson Faria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Receptors P1 And P2 As Targets For Drug Therapy In Humans written by Robson Faria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives
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Author : Rosa Gomez-Villafuertes
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives written by Rosa Gomez-Villafuertes and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.