Purinergic Approaches In Experimental Therapeutics
DOWNLOAD
FREE 30 Days
Download Purinergic Approaches In Experimental Therapeutics PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Purinergic Approaches In Experimental Therapeutics book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Purinergic Approaches In Experimental Therapeutics
DOWNLOAD
FREE 30 Days
Author : Kenneth A. Jacobson
language : en
Publisher: Wiley-Liss
Release Date : 1997-07-15
Purinergic Approaches In Experimental Therapeutics written by Kenneth A. Jacobson and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-15 with Medical categories.
Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellularhomeostasis and disease etiology have come to be understoodgradually over the past 40 years. However, due to the recentcloning and expression of receptors for ATP and adenosine, novelcompounds have been developed with unique therapeutic potential forthe treatment of thrombosis, stroke, epilepsy, chronic pain,immunological disorders, and cancer. As a result, the study ofadenosine- and ATP-mediated responses in cellular regulation isentering a phase of opportunity and development unmatched since thedays of serotonin receptor research in the 1970s. The only definitive book on the topic, Purinergic Approaches inExperimental Therapeutics covers all of the major therapeuticapplications of purinergic receptors and reflects the very latestdevelopments in this new area of therapeutic research. Twenty-eightchapters, authored by an international group of contributors whoare the leading authorities in the field, provide details onmolecular pharmacology; medicinal chemistry; and therapeuticimplications, including cardiology, metabolism, immunology,neurology, and cancer. Among the topics covered: * Purinergic Neurotransmission and Neuromodulation: A HistoricalPerspective * Adenosine Receptor Subtypes: New Insights from Cloning andFunctional Studies * Modulators of Adenosine Uptake, Release, and Inactivation * Cardiac Electrophysiology of Adenosine: Antiarrhythmic andProarrhythmic Actions * Purinergic Modulation of Gastrointestinal Function * The Role of Adenosine in Asthma * ATP in Brain Function * ATP in the Treatment of Cancer For researchers in pharmacology, physiology, molecular biology, andmedicinal chemistry, Purinergic Approaches in ExperimentalTherapeutics heralds an exciting new era in the understanding ofpurinergic neurotransmission and the development of noveltherapeutic modalities.
Drug Discovery Strategies And Methods
DOWNLOAD
FREE 30 Days
Author : Alexandros Makriyannis
language : en
Publisher: CRC Press
Release Date : 2003-11-04
Drug Discovery Strategies And Methods written by Alexandros Makriyannis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-04 with Medical categories.
Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
Purinergic And Pyrimidinergic Signalling Ii
DOWNLOAD
FREE 30 Days
Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purinergic And Pyrimidinergic Signalling Ii written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Therapeutic Targets In Airway Inflammation
DOWNLOAD
FREE 30 Days
Author : N. Tony Eissa
language : en
Publisher: CRC Press
Release Date : 2003-05-13
Therapeutic Targets In Airway Inflammation written by N. Tony Eissa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-13 with Medical categories.
This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Neuropsychopharmacology
DOWNLOAD
FREE 30 Days
Author : Kenneth L. Davis
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2002
Neuropsychopharmacology written by Kenneth L. Davis and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Purinergic And Pyrimidinergic Signalling
DOWNLOAD
FREE 30 Days
Author : Maria P. Abracchio
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-12
Purinergic And Pyrimidinergic Signalling written by Maria P. Abracchio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-12 with Medical categories.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Nucleotides And Their Receptors In The Nervous System
DOWNLOAD
FREE 30 Days
Author : P. Illes
language : en
Publisher: Elsevier
Release Date : 1999-08-31
Nucleotides And Their Receptors In The Nervous System written by P. Illes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-31 with Science categories.
The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated. Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides. At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide. An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.
Current Pharmaceutical Design
DOWNLOAD
FREE 30 Days
Author :
language : en
Publisher:
Release Date : 1998-10
Current Pharmaceutical Design written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10 with categories.
Purinergic Signalling And The Nervous System
DOWNLOAD
FREE 30 Days
Author : Geoffrey Burnstock
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-05
Purinergic Signalling And The Nervous System written by Geoffrey Burnstock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Medical categories.
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Purine And Pyrimidine Metabolism In Man X
DOWNLOAD
FREE 30 Days
Author : Esther Zoref-Shani
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Purine And Pyrimidine Metabolism In Man X written by Esther Zoref-Shani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Science categories.
th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.