Therapeutic Targets In Airway Inflammation
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Therapeutic Targets In Airway Inflammation
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Author : N. Tony Eissa
language : en
Publisher: CRC Press
Release Date : 2003-05-13
Therapeutic Targets In Airway Inflammation written by N. Tony Eissa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-13 with Medical categories.
This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Asthma Pathophysiology Herbal And Modern Therapeutic Interventions
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Author : Sheikh Rayees
language : en
Publisher: Springer Nature
Release Date : 2021-03-26
Asthma Pathophysiology Herbal And Modern Therapeutic Interventions written by Sheikh Rayees and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-26 with Medical categories.
Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300–1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and β2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.
Obstructive Airway Diseases
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Author : Abhijit Ray
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Obstructive Airway Diseases written by Abhijit Ray and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.
Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation
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Author : Florence E. Roufosse
language : en
Publisher: Frontiers Media SA
Release Date : 2018-12-06
Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation written by Florence E. Roufosse and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-06 with categories.
With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.
New Drugs And Targets For Asthma And Copd
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Author : T.T. Hansel
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010-08-31
New Drugs And Targets For Asthma And Copd written by T.T. Hansel and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-31 with Medical categories.
Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.
Novel Anti Inflammatory Approaches For Cystic Fibrosis Lung Disease Identification Of Molecular Targets And Design Of Innovative Therapies
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Author : Carla Maria Pedrosa Ribeiro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-04
Novel Anti Inflammatory Approaches For Cystic Fibrosis Lung Disease Identification Of Molecular Targets And Design Of Innovative Therapies written by Carla Maria Pedrosa Ribeiro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-04 with Science categories.
Biotherapeutic Approaches To Asthma
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Author : Jan Agosti
language : en
Publisher: CRC Press
Release Date : 2002-07-22
Biotherapeutic Approaches To Asthma written by Jan Agosti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07-22 with Medical categories.
Addressing the need for enhanced drug selectivity and efficacy, Biotherapeutic Approaches to Asthma is an authoritative and timely guide for respiratory specialists, clinical immunologists, allergists, physiologists, pulmonologists, otolaryngologists, and medical school students in these disciplines. It contains emerging data on the importance of c
Pulmonary Pharmacology
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-08-02
Pulmonary Pharmacology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Medical categories.
Pulmonary Pharmacology, Volume 98 provides in-depth reviews on the latest progresses about respiratory drug discovery and development. Topics covered in this volume include corticosteroids, monoclonal antibodies, tyrosine kinase inhibitors and phosphodiesterase inhibitors for the treatments of asthma, COPD or pulmonary fibrosis, with perspective on the development of novel therapeutic strategies such as renin-angiotensin system modulators, mitochondrial function modulators, and non-antibacterial macrolides. Part of the volume is devoted to senotherapy for lung ageing in respiratory diseases, and novel pulmonary delivery technologies, including inhaled biologics. Provides accurate reviews from leading experts on the topic of pulmonary pharmacology Each chapter of the volume provides consolidated graphical materials for ease of reading for the audience Provides the latest insights and future perspectives on the drug discovery and development for respiratory diseases
Airway Smooth Muscle In Asthma And Copd
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Author : Kian Fan Chung
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Airway Smooth Muscle In Asthma And Copd written by Kian Fan Chung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. Authoritative update on key mechanisms of airway constriction in Asthma and COPD Relates latest research to bronchodilator therapy Multi-contributed text, co-coordinated by two of the leading authorities in the field.
Asthma
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Author : Nikoletta Rovina
language : en
Publisher: MDPI
Release Date : 2021-01-07
Asthma written by Nikoletta Rovina and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-07 with Medical categories.
Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.