Quantitative Biopharmaceutical Applications Of Capillary Electrophoresis
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Quantitative Biopharmaceutical Applications Of Capillary Electrophoresis
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Author : Junge Zhang
language : en
Publisher:
Release Date : 2009
Quantitative Biopharmaceutical Applications Of Capillary Electrophoresis written by Junge Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Capillary electrophoresis categories.
Introduction To Quantitative Applications Of Capillary Electrophoresis In Pharmaceutical Analysis
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Author : Kevin D. Altria
language : en
Publisher:
Release Date : 1994
Introduction To Quantitative Applications Of Capillary Electrophoresis In Pharmaceutical Analysis written by Kevin D. Altria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Capillary Electrophoresis Of Proteins And Peptides
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Author : Mark A. Strege
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Capillary Electrophoresis Of Proteins And Peptides written by Mark A. Strege and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
Throughout the more than 20 years that have followed the beginnings of capillary electrophoresis (CE), its application to the analysis of proteins and peptides has continued to be reliable, versatile, and productive. Over time, CE has matured to become a superb complement to HLPC, and in many cases has also evolved as an automated and quantitative replacement for conventional slab gel electrophoresis methods such as SDS-PAGE and isoelectric focusing. Within Capillary Electrophoresis of Proteins and Peptides, we have assembled contributions from researchers who are applying state-of-the-art CE for protein and peptide analysis, including topics that we believe are of great potential both in the present and for the future. In comparison to traditional separation methods, CE represents a miniaturized analysis technique (especially in its microchip-based format) that is highly dependent upon the basic fundamentals of effective sample recovery and high sensitivity detection. With these issues in mind, Chapters 1–4 describe recently developed approaches for both capillary coatings and analyte detection via laser-induced fluorescence. Since the discipline of biotechnology has established itself as a primary platform for the application of CE to the analysis of proteins and peptides, Chapters 5–7 demonstrate a variety of examples of the specific techniques that have been applied for the development of biopharmaceuticals and their commercialization. The methods covered here include also the analysis of oligosaccharides from glycoproteins.
Capillary Electrophoresis And Microchip Capillary Electrophoresis
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Author : Carlos D. García
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-01
Capillary Electrophoresis And Microchip Capillary Electrophoresis written by Carlos D. García and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-01 with Science categories.
Explores the benefits and limitations of the latest capillary electrophoresis techniques Capillary electrophoresis and microchip capillary electrophoresis are powerful analytical tools that are particularly suited for separating and analyzing biomolecules. In comparison with traditional analytical techniques, capillary electrophoresis and microchip capillary electrophoresis offer the benefits of speed, small sample and solvent consumption, low cost, and the possibility of miniaturization. With contributions from a team of leading analytical scientists, Capillary Electrophoresis and Microchip Capillary Electrophoresis explains how researchers can take full advantage of all the latest techniques, emphasizing applications in which capillary electrophoresis has proven superiority over other analytical approaches. The authors not only explore the benefits of each technique, but also the limitations, enabling readers to choose the most appropriate technique to analyze a particular sample. The book's twenty-one chapters explore fundamental aspects of electrophoretically driven separations, instrumentation, sampling techniques, separation modes, detection systems, optimization strategies for method development, and applications. Specific topics include: Critical evaluation of the use of surfactants in capillary electrophoresis Sampling and quantitative analysis in capillary electrophoresis Capillary electrophoresis with electrochemical detection Overcoming challenges in using microchip electrophoresis for extended monitoring applications Capillary electrophoresis of intact unfractionated heparin and related impurities Microchip capillary electrophoresis for in situ planetary exploration Each chapter begins with an introduction and ends with conclusions as well as references to the primary literature. Novices to the field will find this book an easy-to-follow introduction to core capillary electrophoresis techniques and methods. More experienced investigators can turn to the book for troubleshooting tips and expert advice to guide them through the most advanced applications.
Capillary Electrophoresis
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Author : Suvardhan Kanchi
language : en
Publisher: CRC Press
Release Date : 2017-08-21
Capillary Electrophoresis written by Suvardhan Kanchi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-21 with Medical categories.
Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.
Capillary Electrophoresis In Biotechnology And Environmental Analysis
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Author : Hasan Parvez
language : en
Publisher: CRC Press
Release Date : 2023-01-06
Capillary Electrophoresis In Biotechnology And Environmental Analysis written by Hasan Parvez and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-06 with Science categories.
This text aims to evaluate the actual impact of high-performance capillary electrophoresis on analytical biotechnology and environmental analysis. The first part of the book presents a survey of present innovations in instrument design and different methods of pre-concentration techniques in order to obtain increased separations at higher sensitivities. The second part contains articles on applications of HPCE to protein and peptide analysis. In the third part, applications of HPCE in the investigation of drug abuse and drug interactions are presented. The last two parts of the book deal with the use of HPCE at low-UV wavelengths and negative-UV absorption. The book should be of interest to those working in HPCE research and applications.
Capillary Electrophoresis Guidebook
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Author : Kevin D. Altria
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Capillary Electrophoresis Guidebook written by Kevin D. Altria and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
This book is intended to be a working guide to the operation of capillary electrophoresis (CE) instrumentation. Since CE is still a rap idly maturing technique, detailed validated protocols are not widely established. Therefore, extensive experimental procedures are not pro vided for individual analyses. The intention is to provide general guide lines on the principles and practice of CE and to give an overview of the specific technologies and important application areas. Part I provides operating instructions for standard commercially available instruments. Guidelines are included for activities such as changing capillaries, method development, quantitative procedures, optimization of precision and sensitivity, and the validation of meth ods, fraction collection, and troubleshooting, as well as a quick guide to running a separation. The application range of CE is possibly the most diverse of all analytical techniques and ranges from large, complex macromolecules, such as proteins and nucleic acids, to small solutes, such as organic drugs and inorganic anions and cations.
Clinical Applications Of Capillary Electrophoresis
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Author : Stephen M. Palfrey
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Clinical Applications Of Capillary Electrophoresis written by Stephen M. Palfrey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
In Clinical Applications of Capillary Electrophoresis, Stephen Palfrey brings together for first time a collection of detailed capillary electrophoresis protocols designed exclusively for clinical applications. Written by the leading scientists who have often perfected these methods in their own laboratories, the protocols furnish new and more powerful assays for many routine serum and blood tests now regularly performed in clinical laboratories, including urine protein analysis, hemoglobin separation, and the detection of CSF proteins, lipoproteins, myoglobin, cryoglobulins, HbA1c, and cathepsin. The protocols offered for DNA studies include double-stranded DNA analysis, the prenatal diagnosis of Down's syndrome, Rh D/d genotyping, the identification of mutated p53 oncogene, and the detection of microsatellite instability in cancers. Many of the methods can be automated to replace the more costly and labor-intensive tests that are currently used in most clinical laboratories. Clinical Applications of Capillary Electrophoresis demonstrates clearly the simplicity, versatility, and power of CE over conventional methods. It offers to beginning clinical investigators, as well as established laboratories new to the technique, a representative range of highly practical CE methods-assays that are not only certain to become ever more productive, but are already eminently useful today.
Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics
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Author : Reinhard H. H. Neubert
language : en
Publisher: CRC Press
Release Date : 2003-01-14
Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics written by Reinhard H. H. Neubert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-14 with Medical categories.
This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate devel
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis
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Author : S.M. Lunte
language : en
Publisher: Elsevier
Release Date : 1996-08-13
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis written by S.M. Lunte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-13 with Science categories.
The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.