Quantitative Genetics And Complex Trait Analysis In Humans The Genetic Basis Of Complex Diseases
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Quantitative Genetics And Complex Trait Analysis In Humans The Genetic Basis Of Complex Diseases
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Author : Christine Langhoff
language : en
Publisher: GRIN Verlag
Release Date : 2003-06-07
Quantitative Genetics And Complex Trait Analysis In Humans The Genetic Basis Of Complex Diseases written by Christine Langhoff and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-07 with Science categories.
Essay from the year 2002 in the subject Biology - Genetics / Gene Technology, grade: 2.1 (B), Oxford University (New College), language: English, abstract: Ultimately, the goal of genetics is the analysis of the genotype of organisms. But the genotype can be identified – and therefore studied – only through its phenotypic effect. This means that two genotypes are recognised as different from each other because the phenotypes of their carriers are different. A problem can be seen with this approach as the actual variation between organisms is usually quantitative, not qualitative. Many different genotypes may have the same average phenotype. At the same time, because of environmental variation, two individuals of the same genotype may not have the same phenotype. This lack of a one-to-one correspondence between genotype and phenotype obscures underlying Mendelian genetics. I am going to explore the use of various statistical techniques for studying quantitative traits with application to behavioural traits. I am also going to examine whether there are behavioural traits with sufficiently high heritabilities to give hope for gene searches and I am going to discuss the difficulties that confront molecular geneticists regarding psychiatric genetics.
Genetic Analysis Of Complex Disease
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Author : Jonathan L. Haines
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-26
Genetic Analysis Of Complex Disease written by Jonathan L. Haines and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-26 with Science categories.
Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.
Genetics And Analysis Of Quantitative Traits
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Author : Michael Lynch
language : en
Publisher: Sinauer Associates Incorporated
Release Date : 1998-01
Genetics And Analysis Of Quantitative Traits written by Michael Lynch and has been published by Sinauer Associates Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01 with Science categories.
Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
Genetic Analysis Of Complex Disease
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Author : William K. Scott
language : en
Publisher: John Wiley & Sons
Release Date : 2021-11-11
Genetic Analysis Of Complex Disease written by William K. Scott and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-11 with Science categories.
Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
Genetic Dissection Of Complex Traits
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Author : D.C. Rao
language : en
Publisher: Academic Press
Release Date : 2008-04-23
Genetic Dissection Of Complex Traits written by D.C. Rao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-23 with Science categories.
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Five sections on the latest advances in complex traits * Methods for testing with ethical, legal, and social implications * Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Genetic Dissection Of Complex Traits
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Author : D. C. Rao
language : en
Publisher: Academic Press
Release Date : 2001
Genetic Dissection Of Complex Traits written by D. C. Rao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Genetic Dissection of Complex Traits will present the full range of methodologies that are essential for understanding the basis of human genetic disorders, the origin of such diseases, and theories on how to determine one's genetic predisposition to certain genetic diseases.
Computational Genetics And Genomics
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Author : Gary Peltz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-05
Computational Genetics And Genomics written by Gary Peltz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-05 with Medical categories.
Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial.
Genetic Variation And Human Disease
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Author : Kenneth M. Weiss
language : en
Publisher: Cambridge University Press
Release Date : 1993
Genetic Variation And Human Disease written by Kenneth M. Weiss and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
Analysis Of Complex Disease Association Studies
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Author : Eleftheria Zeggini
language : en
Publisher: Academic Press
Release Date : 2010-11-17
Analysis Of Complex Disease Association Studies written by Eleftheria Zeggini and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-17 with Science categories.
According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks
Molecular And Genetic Analysis Of Human Traits
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Author : Gustavo Maroni
language : en
Publisher: Wiley-Blackwell
Release Date : 2000-10-11
Molecular And Genetic Analysis Of Human Traits written by Gustavo Maroni and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-11 with Science categories.
Molecular and Genetic Analysis of Human Traits will address the science student human genetics market. Although incorporating two basic themes: how do we establish that a trait is hereditary, and how is the human genome organized, it will also address relevant clinical examples and key related ethical issues. New attractive features have been added, including a chapter project, and end of chapter exercises which rely on real data. Each chapter includes end of chapter exercises, and references. In-text examples and internet references are cited. Most figures will be 2 color, with some 4 color inserts.