Radiopharmaceuticals And Brain Pathophysiology Studied With Pet And Spect
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Radiopharmaceuticals And Brain Pathophysiology Studied With Pet And Spect
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Author : M. Diksic
language : en
Publisher: CRC Press
Release Date : 2021-09-29
Radiopharmaceuticals And Brain Pathophysiology Studied With Pet And Spect written by M. Diksic and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-29 with Medical categories.
First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.
Radiopharmaceuticals And Brain Pathophysiology Studied With Pet And Spect
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Author : M. Diksic
language : en
Publisher: CRC Press
Release Date : 1990-11-30
Radiopharmaceuticals And Brain Pathophysiology Studied With Pet And Spect written by M. Diksic and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-30 with Medical categories.
This book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.
Molecular Imaging
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Author : Shankar Vallabhajosula
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-13
Molecular Imaging written by Shankar Vallabhajosula and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-13 with Medical categories.
Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.
Spect Imaging Of The Brain
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Author : R. Duncan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Spect Imaging Of The Brain written by R. Duncan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the developed world, images of brain structure are available as an everyday diagnostic aid, and the characteristic appearances of most pathological conditions can be looked up in a textbook. Functional brain imaging is to this day less widely used, partly because most pressing diagnostic questions can be answered by refer ence to the patient's cerebral anatomy, partly for reasons of technical limitations of functional techniques. PET as a technique is sufficiently resource-demanding and complex to inhibit its use as an everyday diagnostic technique. SPECT lacked suitable tracers for many years, and early systems had poor spatial resolution. However, rotating gamma camera technology has advanced to the point where images of the brain of reasonable quality can be obtained at most large hospitals, and practical tracers, particularly of regional cerebral blood flow, are easily avail able. As research advances, clinical applications are emerging. A recent report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology! details a number of currently recognised clinical appli cations, some of which are dealt with in this book. Given this recognition, it is increasingly important that clinicians (particularly neuroclinicians, psychiatrists and specialists in cerebrovascular disease), nuclear medicine specialists and physicists acquire an idea of the major applications of the technique, and the research background on which these applications are based.
Functional Cerebral Spect And Pet Imaging
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Author : Ronald L. Van Heertum
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2009-09-01
Functional Cerebral Spect And Pet Imaging written by Ronald L. Van Heertum and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-01 with Medical categories.
This Fourth Edition reflects the significant recent progress that has occurred in the field of functional brain imaging, particularly the increased use of PET/SPECT, the use of SPECT and PET in movement disorders and dementia, and advances in radiopharmaceutical development and instrumentation. Chapter topics include PET physics and instrumentation, PET radiopharmaceuticals, SPECT radiopharmaceuticals, and technical factors. The entire book has been thoroughly revised to reflect an appropriate balance between SPECT and PET applications. Highlights of this edition include a new chapter on neuroreceptor imaging and kinetic modeling, a new chapter on brain imaging in movement disorders, and significant updates on SPECT radiopharmaceuticals.
Radiolabelled Molecules For Brain Imaging With Pet And Spect
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Author : Peter Brust
language : en
Publisher: MDPI
Release Date : 2020-11-26
Radiolabelled Molecules For Brain Imaging With Pet And Spect written by Peter Brust and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Science categories.
Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body’s functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood–brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors.
Radiopharmaceuticals
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Author : Ferdinando Calabria
language : en
Publisher: Springer Nature
Release Date : 2019-10-12
Radiopharmaceuticals written by Ferdinando Calabria and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-12 with Medical categories.
This book provides a rapid and concise guide to PET (PET/CT and PET/MRI) molecular imaging, concentrating extensive information on PET radiopharmaceuticals in a single volume. The book reflects the rapid development of several PET tracers over the last decade, as a result of which the “traditional” PET/CT with 18F-FDG, the “cornerstone” of PET imaging, is now only one of several available options, which use different tracers for different diseases. For the same reason, PET imaging is no longer limited to the field of oncology. In the editors’ experience, students in medicine and residents in nuclear medicine and radiology have limited access to scientific papers concerning novel PET tracers. Moreover, these papers generally focus on a single PET radiopharmaceutical. With approx. 20 radiopharmaceuticals explained in detail and a wealth of images and clinical cases, the book represents a versatile, comprehensive and practice-oriented guide to PET imaging, pursuing a unique and novel approach to the clinical role of PET tracers. The book’s didactic nature also makes it an invaluable tool for residents in nuclear medicine and radiology, as well as for radiographers and clinicians in radiotherapy, oncology, hematology, cardiology and neurology.
Nuclear Oncology
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Author : H. William Strauss
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-27
Nuclear Oncology written by H. William Strauss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-27 with Medical categories.
This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.
Clinical Applications Of Spect Ct
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Author : Hojjat Ahmadzadehfar
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-05
Clinical Applications Of Spect Ct written by Hojjat Ahmadzadehfar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-05 with Medical categories.
SPECT/CT cameras have considerably improved diagnostic accuracy in recent years based in large part on the better localization and definition of scintigraphic findings. This book covers the full spectrum of clinical applications of SPECT/CT in diagnosis and therapy planning of benign and malignant diseases. Opening chapters discuss the technology and physics of SPECT/CT and its use for dosimetry. The role of SPECT/CT in the imaging of a range of pathologic conditions is then addressed in detail. Applications covered include, among others, imaging of the thyroid, bone, and lungs, imaging of neuroendocrine tumors, cardiac scintigraphy, and sentinel node scintigraphy. Individual chapters are also devoted to therapy planning in selective internal radiation therapy of liver tumors and bremsstrahlung SPECT/CT. Readers will find this book to be an essential and up-to-date source of information on this invaluable hybrid imaging technique.
Diagnostic Nuclear Medicine
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Author : Martin P. Sandler
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2003
Diagnostic Nuclear Medicine written by Martin P. Sandler and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
The gold standard text-reference Diagnostic Nuclear Medicine is now in its Fourth Edition--with a sharp clinical focus, a streamlined new single-volume format, and a very attractive price. Written by the top authorities in the specialty, this brand-new edition offers encyclopedic coverage of clinically relevant developments in nuclear medicine--including instrumentation, radiopharmaceuticals, and applications. Readers will find the latest on PET, molecular imaging, SPECT myocardial perfusion imaging, monoclonal antibody therapy, and the use of functional imaging studies in oncology. This edition has been trimmed from two volumes to one, so that readers can find exactly what they need quickly, without cross-checking between volumes.