Razoxane And Dexrazoxane Two Multifunctional Agents
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Razoxane And Dexrazoxane Two Multifunctional Agents
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Author : Walter Rhomberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-03
Razoxane And Dexrazoxane Two Multifunctional Agents written by Walter Rhomberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-03 with Medical categories.
Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer ́s disease could be stabilized by one or both these drugs.
Razoxane And Dexrazoxane Two Multifunctional Agents
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Author : Walter Rhomberg
language : en
Publisher: Springer
Release Date : 2010-11-30
Razoxane And Dexrazoxane Two Multifunctional Agents written by Walter Rhomberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-30 with Medical categories.
Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer ́s disease could be stabilized by one or both these drugs.
Molecular Therapies Of Cancer
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Author : Georg F. Weber
language : en
Publisher: Springer
Release Date : 2015-07-22
Molecular Therapies Of Cancer written by Georg F. Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-22 with Medical categories.
Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.
Diagnosis And Treatment Of Parkinson S Disease State Of The Art
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Author : Horst Przuntek
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-01
Diagnosis And Treatment Of Parkinson S Disease State Of The Art written by Horst Przuntek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Medical categories.
Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson’s disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson’s disease. It is evident, that many questions on the cause, course and treatment of Parkinson’s disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.
Cancer Therapeutics
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-12-03
Cancer Therapeutics written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-03 with Medical categories.
Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.
Dna Topoisomerases And Cancer
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Author : Yves Pommier
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-21
Dna Topoisomerases And Cancer written by Yves Pommier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Medical categories.
DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.
Advances In Molecular Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-09-15
Advances In Molecular Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-15 with Medical categories.
Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. Provides cutting-edge reviews by leading workers in the discipline Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians and any student in the allied disciplines Presents leading-edge applications of technological innovations in chemistry, biochemistry and molecular medicine
Cancer Treatment And The Heart
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Author : Franco M. Muggia
language : en
Publisher:
Release Date : 1992
Cancer Treatment And The Heart written by Franco M. Muggia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Literary Criticism categories.
A foundational investigation of disorders of the heart resulting from cancer treatment, with conclusions about common mechanisms. Seventeen contributed chapters are arranged in five parts: cytotoxic myocardial disease--preclinical study, cytotoxic myocardial disease--clinical study, myocardial disease--radiation and biologics, pericardial disease, and other cardiovascular disease. Annotation copyright by Book News, Inc., Portland, OR
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Clinical Fluid Therapy In The Perioperative Setting
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Author : Robert G. Hahn
language : en
Publisher: Cambridge University Press
Release Date : 2016-05-26
Clinical Fluid Therapy In The Perioperative Setting written by Robert G. Hahn and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-26 with Medical categories.
The world's most renowned researchers in fluid management explain what you should know when providing infusion fluids to surgical patients.