Reactive Oxygen Species Ros Key Components In Cancer Immunotherapy
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Reactive Oxygen Species Ros Key Components In Cancer Immunotherapy
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Author : Anwen Shao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-12
Reactive Oxygen Species Ros Key Components In Cancer Immunotherapy written by Anwen Shao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-12 with Medical categories.
The class of highly bioactive chemicals known as reactive oxygen species (ROS) has been extensively explored in relation to several malignancies and is thought to be a typical by-product of many cellular functions. Cancer cells have greater baseline ROS concentrations than healthy cells because of an imbalance between oxidants and antioxidants. At low to moderate levels, ROS functions as a signal transducer to drive cell proliferation, migration, invasion, and angiogenesis. ROS also has a second role in cellular metabolism. On the other hand, excessive ROS may kill cells by harming organelles, membranes, lipids, proteins, and nucleic acids. Numerous studies have shown that anticancer treatments that regulate ROS levels, such as immunotherapy, provide encouraging outcomes both in vitro and in vivo.
Role Of Autophagy And Reactive Oxygen Species In Cancer Treatment
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Author : Neeraj Mishra
language : en
Publisher: Springer Nature
Release Date : 2024-09-01
Role Of Autophagy And Reactive Oxygen Species In Cancer Treatment written by Neeraj Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Science categories.
Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.
Innovative Medicine
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Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Immunotherapy Side Effects A Comprehensive Analysis Of Adverse Reactions And Therapeutic Strategies
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-02-19
Immunotherapy Side Effects A Comprehensive Analysis Of Adverse Reactions And Therapeutic Strategies written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-19 with Medical categories.
Immunotherapy Side Effects: A Comprehensive Analysis of Adverse Reactions and Therapeutic Strategies offers an in-depth exploration of the side effects associated with immunotherapy treatments. This treatise provides a detailed examination of various immune-related adverse events (IRAEs), including skin, endocrine, gastrointestinal, pulmonary, neurological, renal, and hematologic manifestations. It delves into the mechanisms underlying these side effects, discusses current management practices, and reviews emerging therapeutic strategies. With a focus on both local and systemic effects, this comprehensive guide aims to equip healthcare professionals with the knowledge to effectively manage immunotherapy-related toxicities. It includes insights into novel treatments, ongoing research, and clinical trial findings, making it an essential resource for clinicians, researchers, and students seeking a thorough understanding of the complexities of immunotherapy side effects and their management.
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches
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Author : Rifat Hamoudi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-02
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches written by Rifat Hamoudi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-02 with Medical categories.
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2022-10-20
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-20 with Medical categories.
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
The Biomarkers Mechanism And Therapeutic Strategies Of Cancer Immunotherapy Resistance
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Author : Mou Peng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-30
The Biomarkers Mechanism And Therapeutic Strategies Of Cancer Immunotherapy Resistance written by Mou Peng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-30 with Science categories.
Over the decades, cancer immunotherapy has been a burgeoning science in medicine and an established pillar of therapeutic options for diverse cancer types. Leading the way to success is mainly the discovery and development of immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cell-based therapies. Under immunotherapy, a portion of cancer patients enables to achieve a significant and durable remission with a longer survival time, particularly in those with lung cancer, melanoma, genitourinary cancer, etc. However, striking disparities still exist in the effectiveness of anticancer immunotherapy and cause a great challenge to select appropriate candidates. A large part of cancer patients presents limited or no response to immunotherapy, mainly attributable to immunotherapy resistance. Despite of great strides already made, the exact mechanism underlying immunotherapy resistance is still enigmatic. Immunotherapy resistance is extremely complex and involves voluminous aspects such as tumor-intrinsic factors (aberrant expression of tumor antigens, alterations of signaling pathways, etc.), tumor-extrinsic factors (local tumor microenvironment, etc.) and host-related factors (gender, age, etc.). More efforts should be made to characterize the underlying mechanism and uncover robust targets for a better response rate.
B Cell Receptor Signaling
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Author : Tomohiro Kurosaki
language : en
Publisher: Springer
Release Date : 2015-12-26
B Cell Receptor Signaling written by Tomohiro Kurosaki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-26 with Medical categories.
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Cancer Chemotherapy Immunotherapy And Biotherapy
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Author : Bruce A. Chabner
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2024-06-18
Cancer Chemotherapy Immunotherapy And Biotherapy written by Bruce A. Chabner and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Medical categories.
Focusing on individual patient needs, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Seventh Edition, provides thorough, comprehensive information from Drs. Bruce A. Chabner, Dan L. Longo, and an authoritative team of clinicians and scientists working at renowned cancer centers across the globe. It covers fundamental information about mechanism of action, pharmacokinetics, clinical toxicity, and drug interactions, all essential to the safe and effective use of the drug.
Treatment And Prognostic Assessment Of Liver Cirrhosis And Its Complications Volume Ii
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Author : Xingshun Qi
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-14
Treatment And Prognostic Assessment Of Liver Cirrhosis And Its Complications Volume Ii written by Xingshun Qi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-14 with Medical categories.
Given the success of Research Topic Treatment and Prognostic Assessment of Liver Cirrhosis and Its Complications and the rapidly evolving subject area, we are pleased to announce the launch of Volume II. About 2 million deaths worldwide annually are attributable to liver diseases. Among them, half die from cirrhosis and the other half from viral hepatitis and hepatocellular carcinoma. When patients with liver cirrhosis develop to the decompensated stage, a variety of complications will occur, such as ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, and jaundice, which will seriously affect the patient's quality of life with reduced survival time and increased socioeconomic burden. Therefore, early assessment and clinical management of cirrhosis and its complications are crucial for both clinicians and patients.