Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches
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Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches
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Author : Rifat Hamoudi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-02
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches written by Rifat Hamoudi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-02 with Medical categories.
Cancer Immunology And Immunotherapy
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Author : Mansoor M. Amiji
language : en
Publisher: Elsevier
Release Date : 2021-08-27
Cancer Immunology And Immunotherapy written by Mansoor M. Amiji and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Business & Economics categories.
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
The Basics Of Cancer Immunotherapy
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Author : Haidong Dong
language : en
Publisher: Springer
Release Date : 2018-01-05
The Basics Of Cancer Immunotherapy written by Haidong Dong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-05 with Medical categories.
This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.
Computational Systems Biology Approaches In Cancer Research
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Author : Inna Kuperstein
language : en
Publisher: CRC Press
Release Date : 2019-09-09
Computational Systems Biology Approaches In Cancer Research written by Inna Kuperstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-09 with Computers categories.
Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’
Immunotherapy
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Author : Aung Naing
language : en
Publisher: Springer Nature
Release Date : 2020-04-16
Immunotherapy written by Aung Naing and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-16 with Medical categories.
Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.
New Insights In Veterinary Cancer Immunology
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Author : Carlos Eduardo Fonseca-Alves
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-14
New Insights In Veterinary Cancer Immunology written by Carlos Eduardo Fonseca-Alves and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-14 with Science categories.
The tumour microenvironment (TME) is essential for cancer maintenance and is responsible for several antitumor characteristics, such as immune system avoidance, resistance to anticancer therapies, invasion, and metastasis. The TME is composed of several components, including fibroblasts, extracellular matrix proteins, pericytes, and immune cells. The immune cells, including T-lymphocytes, are responsible for fighting cancer cells, inducing cell death. However, cancer cells develop several mechanisms to avoid the immune system, including mutations to change the antigens originally recognised by T-cells. Tumours that can avoid the immune system, including the T-cell antitumor response, are known as nonimmunogenic tumours or “cold” tumours. The main characteristic of this tumour subtype is lack of response to immunotherapy drugs. In contrast, immunogenic, or “hot” tumours have an active T-cell antitumor response and respond well to immunotherapy. Therefore, elucidating the TME characteristics is the first step for the application in clinical practice. In recent years, there has been progress in understanding how the immune system and inflammation are associated with different cancer subtypes. In 2018, the Nobel Prize in Physiology and Medicine was awarded for the discovery of cancer therapy by the inhibition of negative immune regulation. Since then, there has been an increase in global attention directed towards the immune system and its implications for cancer therapy. Tumour progression is highly dependent of modifications in the TME, which are directly related with patient’s prognosis and present direct impacts on chemotherapy efficiency. Investigating and comprehending the TME composition during tumour progression allows new therapeutic strategies and approaches personalized to each patient. Thus, understanding its complex interactions leads to different strategies to reprogramming TME for therapeutic purposes. The main goal of this special issue is to bring together manuscripts focused on cancer immunology with a translational approach. We welcome Original Research and Review articles from investigators worldwide that will stimulate the continuing efforts to understand the interactions with tumour microenvironment, including: 1) Identification of immune cells as a prognostic factor for cancer in veterinary patients. 2) Stratification of tumour in animals according to its immunological content (hot or cold tumours) 3) Specific therapies targeting immune system components with translational potential 4) Genetic and epigenetic cancer modifications associated with the immune cells 5) Therapeutic implications of antitumor vaccines in small animals
Systems Biology And In Depth Applications For Unlocking Diseases
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Author : Babak Sokouti
language : en
Publisher: Elsevier
Release Date : 2024-11-05
Systems Biology And In Depth Applications For Unlocking Diseases written by Babak Sokouti and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-05 with Science categories.
Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment.Systematically written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more.This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field. - Provides detailed and comprehensive coverage of the field of systems biology - Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment - Makes effective steps towards personalized medicine in the treatment of disease - Explains effective disease treatment strategies at early diagnosis stages
Systems Biology Approaches Prevention Diagnosis And Understanding Mechanisms Of Complex Diseases
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Author : Sanket Joshi
language : en
Publisher: Springer Nature
Release Date : 2024-05-16
Systems Biology Approaches Prevention Diagnosis And Understanding Mechanisms Of Complex Diseases written by Sanket Joshi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-16 with Science categories.
This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease mechanisms. It explores the applications of system biology in infectious diseases, including host-pathogen interaction, and the identification of targets for new therapeutics and intervention strategies. It covers the use of system biology for understanding and treating metabolic disorders towards personalized and precision medicine. The book further discusses the systems biology approaches for understanding the mechanisms of tumor progression and designing more effective cancer therapies. The chapter also reviews the current strategies in autoimmune disease treatment and highlights the opportunity that systems biology represents for the development of better and safer treatments. Importantly, the book discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions usingsystem biology approaches. Cutting across the disciplines, this book is a valuable source for researchers in genetics, molecular biology, cell biology, microbiology, and biomedical sciences.
Cancer Immunotherapy And Biological Cancer Treatments
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Author : Hilal Arnouk
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-11-13
Cancer Immunotherapy And Biological Cancer Treatments written by Hilal Arnouk and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-13 with Medical categories.
In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.
Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention
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Author : Wenyi Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention written by Wenyi Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
In the realm of modern immunology, the pursuit of precision therapeutics has emerged as a paramount endeavor. This research field harnesses the power of advanced multi-omics technologies and comprehensive methodologies to revolutionize personalized immune interventions. Immunotherapy, a cornerstone of precision medicine, targets the intricate dynamics of the immune system to combat diseases ranging from cancer to autoimmune disorders. Integrating multi-omics analyses, including genomics, transcriptomics, proteomics, and metabolomics, enables a holistic understanding of immune responses at various molecular levels. Immune signatures derived from these analyses unveil individualized patterns, offering crucial insights into disease susceptibility and treatment efficacy. Leveraging this wealth of data through sophisticated computational models and machine learning algorithms enhances our ability to predict immune responses and identify optimal therapeutic strategies. By amalgamating diverse approaches, from single-cell profiling to spatial transcriptomics, we delve deeper into the complexities of immune regulation and cellular interactions within the microenvironment. Through collaborative efforts, the pursuit of immunological precision therapeutics aims to tailor interventions precisely to each patient's immune landscape, ushering in a new era of personalized immune modulation.