Recent Progresses In Amebiasis
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Recent Progresses In Amebiasis
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Author : Anjan Debnath
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-14
Recent Progresses In Amebiasis written by Anjan Debnath and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-14 with categories.
Amebiasis, a parasitic disease transmitted by the unicellular protozoan parasite Entamoeba histolytica, is the cause of at least 100,000 deaths each year. The disease is mostly prevalent in developing countries and is one of the three common causes of death from parasitic diseases. The parasite has two stages in its life cycle in the host: the infective cyst and the invasive trophozoite. In the large intestine, the parasite feeds on bacteria and on cellular debris. No vaccine against amebiasis currently exists. Although metronidazole is the drug of choice for treating amebiasis, adverse effects in patients and potential resistance to metronidazole in other protozoa exist. About nine out of 10 people who are infected with E. histolytica are asymptomatic and in those individuals who develop symptoms, bloody diarrhea (amebic colitis) and liver abscess are the most common symptoms. One possible explanation for this observation is the difference in the gut microbiota between individuals that may significantly influence the host’s immune response in amebiasis and E. histolytica's virulence. Amebiasis is characterized by acute inflammation of the intestine with release of pro-inflammatory cytokines, reactive oxygen species and reactive nitrogen species from activated cells of the host's immune system. In recent years, significant advances on the cell biology of Entamoeba infection have been achieved through the development of new genetic tools to manipulate gene expression in the parasite and through the application of Omics tools. In this Research Topic, we welcome high quality original research articles, as well as review, opinion or method articles, on amebiasis including but not limited to the regulation of gene expression, cell biology and signaling, adaptation and resistance to environmental stresses, metabolism, pathogenesis and immunity, pathogenesis and microbiome, drug discovery and drug resistance.
Amebiasis
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Author : Tomoyoshi Nozaki
language : en
Publisher: Springer
Release Date : 2014-12-05
Amebiasis written by Tomoyoshi Nozaki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-05 with Medical categories.
This book documents and presents new developments in the study of amebiasis, one of the neglected tropical diseases. Nearly 50 million people worldwide are infected with the pathogen Entamoeba histolytica, causing large-scale morbidity and mortality particularly in developing countries. This book will help clinicians for better diagnosis and management of the disease, researchers for initiating research projects on some of the poorly understood aspects of the disease and the pathogen, and students for updating their knowledge. The subjects covered range from genomics and molecular and cell biology to drug resistance and new drug development, highlighting major advances in recent years in our understanding due to rapid progress in genomic and other biomedical technologies, such as visualization of molecular processes. Most of the chapters provide recent information based on latest publications. A few chapters describe some of the critical methodological issues that will be helpful for students and researchers interested in getting into the field. The contributing authors include almost all the active researchers and clinicians from around the world. This book will be a useful primary material and a valuable source of information for anyone interested in understanding amebiasis, its diagnosis, and treatment. It will also be useful to those who are interested in learning about the biology of early branching eukaryotes and protist pathogens.
Liver Pathophysiology
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Author : Pablo Muriel
language : en
Publisher: Academic Press
Release Date : 2017-03-02
Liver Pathophysiology written by Pablo Muriel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-02 with Medical categories.
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
American Academy Of Pediatrics Textbook Of Pediatric Care
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Author : Jane Meschan Foy
language : en
Publisher:
Release Date : 2016-03-31
American Academy Of Pediatrics Textbook Of Pediatric Care written by Jane Meschan Foy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-31 with Children categories.
The definitive manual of pediatric medicine - completely updated with 75 new chapters and e-book access.
Drug Development For Parasite Induced Diarrheal Diseases
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Author : Anjan Debnath
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-25
Drug Development For Parasite Induced Diarrheal Diseases written by Anjan Debnath and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-25 with Electronic book categories.
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.
Recent Progress In Slow Sand And Alternative Biofiltration Processes
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Author : Rolf Gimbel
language : en
Publisher: IWA Publishing
Release Date : 2006-03-31
Recent Progress In Slow Sand And Alternative Biofiltration Processes written by Rolf Gimbel and has been published by IWA Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-31 with Science categories.
Slow sand filtration is typically cited as being the first "engineered" process in drinking-water treatment. Proven modifications to the conventional slow sand filtration process, the awareness of induced biological activity in riverbank filtration systems, and the growth of oxidant-induced biological removals in more rapid-rate filters (e.g. biological activated carbon) demonstrate the renaissance of biofiltration as a treatment process that remains viable for both small, rural communities and major cities. Biofiltration is expected to become even more common in the future as efforts intensify to decrease the presence of disease-causing microorganisms and disinfection by-products in drinking water, to minimize microbial regrowth potential in distribution systems, and where operator skill levels are emphasized. Recent Progress in Slow Sand and Alternative Biofiltration Processes provides a state-of-the-art assessment on a variety of biofiltration systems from studies conducted around the world. The authors collectively represent a perspective from 23 countries and include academics, biofiltration system users, designers, and manufacturers. It provides an up-to-date perspective on the physical, chemical, biological, and operational factors affecting the performance of slow sand filtration (SSF), riverbank filtration (RBF), soil-aquifer treatment (SAT), and biological activated carbon (BAC) processes. The main themes are: comparable overviews of biofiltration systems; slow sand filtration process behavior, treatment performance and process developments; and alternative biofiltration process behaviors, treatment performances, and process developments.
Paniker S Textbook Of Medical Parasitology
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Author : C. K. Jayaram Paniker
language : en
Publisher: JP Medical Ltd
Release Date : 2017-09-14
Paniker S Textbook Of Medical Parasitology written by C. K. Jayaram Paniker and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
The new edition of this textbook is a complete guide to parasitology for undergraduate medical students. Divided into 23 chapters, each topic has been thoroughly updated and expanded to cover the most recent advances and latest knowledge in the field. The book begins with an overview of parasitology, then discusses numerous different types of parasite, concluding with a chapter on diagnosis methods. Many chapters have been rewritten and the eighth edition of the book features many new tables, flow charts and photographs. Each chapter concludes with a ‘key points’ box to assist with revision. Key points Eighth edition providing undergraduates with a complete guide to parasitology Fully revised text with many new topics, tables and photographs Each chapter concludes with ‘key points’ box to assist revision Previous edition (9789350905340) published in 2013
Multicriteria Based Ranking For Risk Management Of Food Borne Parasites
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Author : Pascal Boireau
language : en
Publisher: Food & Agriculture Organization of the UN (FAO)
Release Date : 2014
Multicriteria Based Ranking For Risk Management Of Food Borne Parasites written by Pascal Boireau and has been published by Food & Agriculture Organization of the UN (FAO) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Business & Economics categories.
This product documents the process by which foodborne parasites were ranked from a global food safety perspective and provides a ranking and information on all the top ranked parasites both generally and from a regional perspective. It directly supports the establishment of international standards on foodborne parasites by the Codex Alimentarius which are agreed by countries and can then be used as a basis for improving the safety of specific products and facilitation their trade internationally. These in turn directly contribute to the SO by promoting more efficient and inclusive trade.
Foodborne Parasites
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Author : Ynes R. Ortega
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-22
Foodborne Parasites written by Ynes R. Ortega and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-22 with Technology & Engineering categories.
This book examines the two major parasite groups that are transmitted via water or foods: the single-celled protozoa, and the helminths: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). Each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites. This important new text offers a better understanding of the biology and control of parasitic infections necessary to reduce or eliminate future outbreaks in the U.S. and elsewhere.
Oxidative Stress In Microbial Diseases
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Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2019-11-12
Oxidative Stress In Microbial Diseases written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-12 with Science categories.
This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.