Redox Signaling And Biomarkers In Ageing
DOWNLOAD
Download Redox Signaling And Biomarkers In Ageing PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Redox Signaling And Biomarkers In Ageing book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Redox Signaling And Biomarkers In Ageing
DOWNLOAD
Author : Ufuk Çakatay
language : en
Publisher: Springer Nature
Release Date : 2021-12-02
Redox Signaling And Biomarkers In Ageing written by Ufuk Çakatay and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-02 with Medical categories.
This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.
Redox Signaling And Biomarkers In Ageing
DOWNLOAD
Author : Ufuk Çakatay
language : en
Publisher:
Release Date : 2022
Redox Signaling And Biomarkers In Ageing written by Ufuk Çakatay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Brain Aging
DOWNLOAD
Author : David R. Riddle
language : en
Publisher: CRC Press
Release Date : 2007-04-19
Brain Aging written by David R. Riddle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-19 with Medical categories.
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Senescence Senotherapeutics And Mitochondria
DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 2023-07-14
Senescence Senotherapeutics And Mitochondria written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-14 with Science categories.
Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. - Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies - Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches - Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
Measurement Of Antioxidant Activity And Capacity
DOWNLOAD
Author : Resat Apak
language : en
Publisher: John Wiley & Sons
Release Date : 2017-11-30
Measurement Of Antioxidant Activity And Capacity written by Resat Apak and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-30 with Technology & Engineering categories.
A comprehensive reference for assessing the antioxidant potential of foods and essential techniques for developing healthy food products Measurement of Antioxidant Activity and Capacity offers a much-needed resource for assessing the antioxidant potential of food and includes proven approaches for creating healthy food products. With contributions from world-class experts in the field, the text presents the general mechanisms underlying the various assessments, the types of molecules detected, and the key advantages and disadvantages of each method. Both thermodynamic (i.e. efficiency of scavenging reactive species) and kinetic (i.e. rates of hydrogen atom or electron transfer reactions) aspects of available methods are discussed in detail. A thorough description of all available methods provides a basis and rationale for developing standardized antioxidant capacity/activity methods for food and nutraceutical sciences and industries. This text also contains data on new antioxidant measurement techniques including nanotechnological methods in spectroscopy and electrochemistry, as well as on innovative assays combining several principles. Therefore, the comparison of conventional methods versus novel approaches is made possible. This important resource: Offers suggestions for assessing the antioxidant potential of foods and their components Includes strategies for the development of healthy functional food products Contains information for identifying antioxidant activity in the body Presents the pros and cons of the available antioxidant determination methods, and helps in the selection of the most appropriate method Written for researchers and professionals in the nutraceutical and functional food industries,academia and government laboratories, this text includes the most current knowledge in order to form a common language between research groups and to contribute to the solution of critical problems existing for all researchers working in this field.
Molecular Basis Of Nutrition And Aging
DOWNLOAD
Author : Marco Malavolta
language : en
Publisher: Academic Press
Release Date : 2016-04-15
Molecular Basis Of Nutrition And Aging written by Marco Malavolta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-15 with Science categories.
Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition
Cellular Ageing And Replicative Senescence
DOWNLOAD
Author : Suresh I.S. Rattan
language : en
Publisher: Springer
Release Date : 2016-05-09
Cellular Ageing And Replicative Senescence written by Suresh I.S. Rattan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-09 with Medical categories.
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.
Human Aging
DOWNLOAD
Author : Calogero Caruso
language : en
Publisher: Elsevier
Release Date : 2021-05-13
Human Aging written by Calogero Caruso and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-13 with Medical categories.
Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities -- 2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy -- 3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP -- 4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References.
Biochemistry And Cell Biology Of Ageing Part Iii Biomedical Science
DOWNLOAD
Author : J. Robin Harris
language : en
Publisher: Springer Nature
Release Date : 2023-01-04
Biochemistry And Cell Biology Of Ageing Part Iii Biomedical Science written by J. Robin Harris and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-04 with Family & Relationships categories.
This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
DOWNLOAD
Author : Luciano Merlini
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-18
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach written by Luciano Merlini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-18 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.