Regulation And Contraction Of Smooth Muscle
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Regulation And Contraction Of Smooth Muscle
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Author : International Union of Physiological Sciences. Satellite Conference on Smooth Muscle Contraction
language : en
Publisher: New York : Liss
Release Date : 1987
Regulation And Contraction Of Smooth Muscle written by International Union of Physiological Sciences. Satellite Conference on Smooth Muscle Contraction and has been published by New York : Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Nature categories.
Regulation Of Smooth Muscle Contraction
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Author : Robert S. Moreland
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulation Of Smooth Muscle Contraction written by Robert S. Moreland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Sixth Annual Graduate Hospital Research Symposium REGULATION OF SMOOTH MUSCLE PROGRESS IN SOLVING THE PUZZLE Every so often a scientific conference comes at a time when everyone has new and exciting information, when old "dogmas" do not seem to be as well established, and when speakers and participants alike are ready to challenge interpretations of old and new experimental data. This was such a conference. What turns on a smooth muscle cell? The precise answer to this question has eluded scientists for much longer than I have been involved in the field. We know that an increase in cytosolic calcium is necessary and we know that phosphorylation of the 20 kDa myosin light chain is an important step in the process. We do not know if other processes are necessary for the initiation and lor maintenance of a smooth muscle contraction nor do we know if other processes modulate the regulation of contraction. The goal of the symposium on which this volume is based was to explore the most current hypotheses for the answers to these questions. I believe that after reading the chapters included in this volume, you will agree that this goal was achieved. The importance of calcium and calmodulin dependent myosin light chain phosphoryla tion in the regulation of smooth muscle contraction was reinforced by many presentations. However, the status of myosin light chain phosphorylation as a simple calcium dependent switch came under serious suspicion.
Regulation Of Smooth Muscle Contraction
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Author : Robert S Moreland
language : en
Publisher:
Release Date : 1992-01-31
Regulation Of Smooth Muscle Contraction written by Robert S Moreland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-31 with categories.
Regulation And Contraction Of Smooth Muscle
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Author : Marion J. Siegman
language : en
Publisher: Wiley-Liss
Release Date : 1987-10-25
Regulation And Contraction Of Smooth Muscle written by Marion J. Siegman and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-10-25 with Medical categories.
Spanning a broad spectrum of experimental approaches, this volume explores the problem of regulation and contraction of smooth muscle at every level, from the molecular to the whole tissue. It offers insights into various areas of this field that are not yet fully understood, such as the molecular packing of the native myosin filaments and the conformational changes of the crossbridge associated with the ATPase cycle. Among other topics discussed are ultrastructure and crossbridge kinetics, biochemistry of contractile and regulatory proteins, pharmacological probes of regulatory systems, mechanics and energetics, and regulatory mechanisms in intact and skinned muscles. Also highlights a number of outstanding reports, including a review of the ultrastructural techniques that have enabled the visualization of crossbridges in smooth muscle in the rigor state. In addition, the book also reviews a major hypothesis on the role of myosin light chain phosphorylation as the key element in regulation of the contractile process by calcium.
Regulation Of The Contractile Cycle In Smooth Muscle
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Author : Takeshi Nakano
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulation Of The Contractile Cycle In Smooth Muscle written by Takeshi Nakano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle. The present volume collects the papers presented at the symposium, summarizing the latest advances in smooth muscle function and emphasizing important components of the contraction-relaxation cycle. Topics include a discussion of the smooth muscle cell membrane, with emphasis on its ion channels; the regulation of cytosolic Ca2+ levels and the relationship to force in smooth muscle; aspects of the two key regulatory enzymes involved with myosin phosphorylation-dephosphorylation; the molecular basis for pharmacomechanical coupling in smooth muscle; developments in the basic contractile mechanisms involving the crossbridge cycle of tonic and phasic muscle; the role of myosin light chains; and many others. The approach is broad and presents contemporary opinions in pharmacology, physiology, and biochemistry as they relate to smooth muscle function. The book will appeal not only to those working in these disciplines, but to vascular clinicians, obstetric-gynecological physicians, and gastroenterologists as well.
Signal Transduction And Protein Phosphorylation
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Author : L.M.G. Heilmeyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Signal Transduction And Protein Phosphorylation written by L.M.G. Heilmeyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Colonic Motility
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Author : Sushil K. Sarna
language : en
Publisher: Biota Publishing
Release Date : 2010-11-01
Colonic Motility written by Sushil K. Sarna and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-01 with Medical categories.
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Airways Smooth Muscle Biochemical Control Of Contraction And Relaxation
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Author : David Raeburn
language : en
Publisher: Birkhäuser
Release Date : 2013-11-11
Airways Smooth Muscle Biochemical Control Of Contraction And Relaxation written by David Raeburn and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Biochemistry Of Smooth Muscle Contraction
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Author : Michael Barany
language : en
Publisher: Elsevier
Release Date : 1996-01-04
Biochemistry Of Smooth Muscle Contraction written by Michael Barany and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-04 with Science categories.
This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Smooth Muscle Contraction Its Regulatory Mechanisms
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Author : Kazuhiro Kohama
language : en
Publisher:
Release Date : 1995
Smooth Muscle Contraction Its Regulatory Mechanisms written by Kazuhiro Kohama and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Muscle contraction categories.