Regulation Of Eukaryotic Translation Initiation
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Regulation Of Eukaryotic Translation Initiation
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Author : Christina Lorraine Shenvi
language : en
Publisher:
Release Date : 2005
Regulation Of Eukaryotic Translation Initiation written by Christina Lorraine Shenvi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Translation In Eukaryotes
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Author : Hans Trachsel
language : en
Publisher: CRC Press
Release Date : 1991-07-24
Translation In Eukaryotes written by Hans Trachsel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-07-24 with Science categories.
This book presents an up-to-date review of the mechanisms and regulation of translation in eukaryotes. Topics covered include the basic biochemical reactions of translation initiation, elongation and termination, and the regulation of these reactions under different physiological conditions and in virus-infected cells. The book belongs on the shelf of everyone interested in translation in eukaryotes, including students and researchers requiring comprehensive overviews of most aspects of translation and instructors who want to cover these topics at an advanced level.
Functional Regulation Of Eukaryotic Translation Initiation Factors
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Author :
language : en
Publisher:
Release Date : 1999
Functional Regulation Of Eukaryotic Translation Initiation Factors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
The Function And Regulation Of Eukaryotic Translation Initiation Factors
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Author : Andrea Flynn
language : en
Publisher:
Release Date : 1993
The Function And Regulation Of Eukaryotic Translation Initiation Factors written by Andrea Flynn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Examination Of The Structure Function And Regulation Of Eukaryotic Translation Initiation Factor 3 Eif3
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Author : Greg Leon Mayeur
language : en
Publisher:
Release Date : 2001
Examination Of The Structure Function And Regulation Of Eukaryotic Translation Initiation Factor 3 Eif3 written by Greg Leon Mayeur and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Functional Regulation Of Eukaryotic Translation Initiation Factors Microform
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Author : Gregory P. (Gregory Paul) Cosentino
language : en
Publisher: National Library of Canada = Bibliothèque nationale du Canada
Release Date : 1999
Functional Regulation Of Eukaryotic Translation Initiation Factors Microform written by Gregory P. (Gregory Paul) Cosentino and has been published by National Library of Canada = Bibliothèque nationale du Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Regulation Of Translation By Eukaryotic Translation Initiation Factor 4g
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Author : Constanze Kaiser
language : en
Publisher:
Release Date : 2008
Regulation Of Translation By Eukaryotic Translation Initiation Factor 4g written by Constanze Kaiser and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Cell metabolism categories.
Translation control provides a fundamental function of cell metabolism. Protein synthesis is regulated by PI3K/AKT and Ras/MAPK pathways in response to extra- and intracellular stimuli, such as hormone and growth factors, cell cycle progression and various physiological stresses.
Regulation Of Eukaryotic Translation Initiation Factor Expression During T Cell Activation
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Author : Thomas Boal
language : en
Publisher:
Release Date : 1991
Regulation Of Eukaryotic Translation Initiation Factor Expression During T Cell Activation written by Thomas Boal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Regulation Of Eukaryotic Translation Initiation By The Eif4e Binding Proteins
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Author : Francis Poulin
language : en
Publisher:
Release Date : 2003
Regulation Of Eukaryotic Translation Initiation By The Eif4e Binding Proteins written by Francis Poulin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
"The initiation of protein synthesis consists in the recruitment of a ribosome·initiator tRNA complex to the initiation codon of a messenger RNA. In eukaryotes, this process is facilitated by eukaryotic translation initiation factor 4E (eIF4E), which recognizes the cap structure present at the 5' end of all nuclear-transcribed mRNAs. The eIF4E-binding proteins (4E-BPs) inhibit cap-dependent translation by binding to eIF4E, and preventing ribosomal recruitment to the mRNA. The interaction of 4E-BPs with eIF4E is reversible, and it is regulated by the 4E-BPs phosphorylation state. Here I report the isolation of a third member of the 4E-BP family, 4E-BP3, and I demonstrate that it shares all the basic structural and functional characteristics of 4E-BP1 and 4E-BP2. I also analyzed the genomic locus for human 4E-BP3 (EIF4EBP3). I established that EIF4EBP3 can be fused with the gene located immediately upstream, and which encodes the human homologue of Drosophila MASK (Multiple Ankyrin Repeats Single KH domain). Interestingly, the open reading frame of the MASK-BP3 fusion transcript is different from that of 4E-BP3, indicating that the EIF4EBP3 locus encodes two different proteins. Finally, I investigated the biological function of 4E-BP1 by disrupting its gene (Eif4ebp1) in the mouse. Eif4ebp1-/- mice are remarkably lean, and the males' white adipose tissue contains cells exhibiting the distinctive multilocular appearance of brown adipocytes, and it expresses the uncoupling protein 1. Consistent with these observations, translation of the peroxisome proliferator-activated receptor-gamma co-activator 1 (PGC1) is increased in white adipose tissue from Eif4ebp1-/- mice. PGC1 is a transcriptional co-activator implicated in mitochondrial biogenesis and adaptive thermogenesis. These findings demonstrate that 4E-BP1 is a novel regulator of metabolism in mammals." --
Translation And Its Regulation In Cancer Biology And Medicine
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Author : Armen Parsyan
language : en
Publisher: Springer
Release Date : 2014-10-13
Translation And Its Regulation In Cancer Biology And Medicine written by Armen Parsyan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-13 with Medical categories.
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.