Regulation Of Gene Expression In Animal Viruses
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Regulation Of Gene Expression In Animal Viruses
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Author : Luis Carrasco
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulation Of Gene Expression In Animal Viruses written by Luis Carrasco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Viruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the molecular biology of genome replication and gene expression. Whereas viruses use, in general, pathways of macromolecular biosynthesis common to the host cell, they have a cunning ability to adopt unusual mechanisms of gene expression and gene replication, provided these special pathways offer an advantage in competition for cellular resources. Any study of viral gene expression and replication is likely to lead also to new insights in cellular metabolism. The discoveries of cis-acting regulatory elements in transcription, the phenomenon of splicing of pre mRNA, and cap-dependent and cap-independent initiation of translation may be cited as examples. In addition, animal virus genomes contain elements and encode proteins that are very useful for the design of vectors for gene cloning and expression in mammalian cells. Apart from the basic interest in their biology, viruses have gained notoriety, of course, because they are pathogens. Human animal viruses may cause diseases ranging from the deadly (AIDS) to the benign (common cold). All studies on animal viruses potentially lead to the development of tools for their control, be it through prevention by immunization or treatment with antiviral drugs. Finally, viruses have yielded invaluable reagents in molecular biology as, for example, the vaccinia virus vector for the expression of foreign genes.
Regulation And Genetics
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Author : H. Fraenkel-Conrat
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulation And Genetics written by H. Fraenkel-Conrat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
Regulation And Genetics Genetics Of Animal Viruses
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Author : Robert R. Wagner
language : en
Publisher: Springer Science & Business Media
Release Date : 1977
Regulation And Genetics Genetics Of Animal Viruses written by Robert R. Wagner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Genetics, microbial categories.
9 Regulation And Genetics Genetics Of Animal Viruses
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Author :
language : en
Publisher:
Release Date : 1977
9 Regulation And Genetics Genetics Of Animal Viruses written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Initiation Signals In Viral Gene Expression
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Author : A. J. Shatkin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Initiation Signals In Viral Gene Expression written by A. J. Shatkin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Elucidating Mechanisms of Eukaryotic Genetic Expression by Studying Animal Viruses AARON 1. SHATIGN* Eukaryotic genetic expression is carefully regulated. Normal cell growth and division, tis sue differentiation, and organism development all depend on a strictly ordered progres sion of specific events. Perturbation of the control of these processes, for example by ex posure to harmful chemicals or infection with viruses leads to aberrant forms of meta bolism, often resulting in malignancies and cell death. One of the most challenging problems in biology is to derme at the molecular level the mechanisms that govern gene function in higher organisms, including ultimately man. This goal serves to unify the diverse efforts of many investigators, whether studying the precise patterns of embryo genesis, the loss of control that occurs during neoplastic growth or the redirection of biosynthetic pathways in virus-infected cells. Recently there has been remarkable and exciting progress toward understanding the molecular biology of eukaryotic expression. Much of this rapidly increasing new infor mation has come from studies of animal virus systems. Just as investigations of the relatively simple, rapidly assayed, and easily manipulated bacteriophages lead to basic discoveries about prokaryotic cells, analyses of animal viruses and their interactions with host cells have provided fundamental information about how eukaryotic nucleic acids are organized for regulated replication, transcription, and translation. For example, the small genome of SV , like cellular DNA in chromatin, is associated with histones to 40 form nucleosomal arrays (Griffin 1975).
Protein Expression In Animal Cells
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Author :
language : en
Publisher: Academic Press
Release Date : 1994-10-18
Protein Expression In Animal Cells written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-10-18 with Science categories.
Critically acclaimed for more than 25 years, the Methods in Cell Biology series provides an indispensable tool for the researcher. Each volume is carefully edited by experts to contain state-of-the-art reviews and step-by-step protocols. Techniques are described completely so that methods are made accessible to users. Describes both well-established and novel recombinant vector systems for expression of proteins Presents methods for efficient delivery of recombinant genes into differentiated cells, tissues, and whole animals Covers high-level and inducible systems, plus assays for protein expression Provides beginning and advanced investigators and students with the information they need to choose the optimal viral or plasmid system for their protein Practical, benchtop-style presentation works in lab and in the classroom
The Nature And Organization Of Retroviral Genes In Animal Cells
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Author : David R. Strayer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
The Nature And Organization Of Retroviral Genes In Animal Cells written by David R. Strayer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
l RNA tumor viruses have become increasingly utilized in studies of cellular transformation and gene regulation. The genes of retroviruses exist in two forms; as extrachromosomal, RNA-containing, infectious particles and as DNA pro 2 viruses stably associated with cell genes. Components from the extracellular form can be collected in large quantity and purified for the preparation of molec ular probes. These probes can be used to dissect the sequence of events required for the establishment and expression of the integrated form. Furthermore the 2 genomes of retroviruses originated from normal cell genes, genes called virogenes • The nucleic acid and protein probes isolated from these viruses are therefore useful for studying the nature and expression of this normal cell gene and in elucidating the physiological role of its products. RNA tumor viruses perhaps offer us one of the most complete sets of biochemical reagents and biological responses for examining gene regulation in vertebrates and for studying the consequences of aberrant gene regulation on cell growth in tissue culture and in animals. Further more, there is an increasing conviction that virogenes play an important role in normal development and/or differentiation (RISSER, STOCKERT and OLD, 1978). Consequently, there is a growing feeling that DNA proviruses are altered viro genes and are capable of interfering with normal development or differentiation, causing reprogrammed growth or the incapacity to specialize.
Rna Viruses
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Author : Decheng Yang
language : en
Publisher: World Scientific
Release Date : 2009
Rna Viruses written by Decheng Yang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.
Herpesvirus Transcription And Its Regulation
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Author : Edward K. Wagner
language : en
Publisher: CRC Press
Release Date : 1991-01-03
Herpesvirus Transcription And Its Regulation written by Edward K. Wagner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-03 with Medical categories.
The herpesviruses are arguably the most successful animal viruses, and nearly 100 distinct examples have been described. Currently, a number of active research groups throughout the world are making important contributions concerning the precise molecular nature of herpesvirus transcripts, the proteins they encode, and the viral and host factors responsible for the control of their expression. Herpesvirus Transcription and Its Regulation describes current programs in a number of leading laboratories and emphasizes the research regarding herpes simplex virus type 1, due primarily to its importance in herpesvirus research. However, several other well-characterized herpesviruses are also described. New research areas covered include molecular analyses of herpesvirus regulatory functions and herpes simplex virus latent phase gene expression. This volume is a timely guide for established research workers and advanced students currently engaged in research on animal virology, viral pathogenesis, and virus-host interactions.
Workshop On The Regulation Of Translation In Animal Virus Infected Cells
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Author :
language : en
Publisher:
Release Date : 1991
Workshop On The Regulation Of Translation In Animal Virus Infected Cells written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Genetic regulation categories.