Regulation Of Vascular Smooth Muscle Cell Growth By Cyclic Nucleotides And Cgmp Dependent Protein Kinase I
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Regulation Of Vascular Smooth Muscle Cell Growth By Cyclic Nucleotides And Cgmp Dependent Protein Kinase I
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Author : Pascal Weinmeister
language : en
Publisher:
Release Date : 2007
Regulation Of Vascular Smooth Muscle Cell Growth By Cyclic Nucleotides And Cgmp Dependent Protein Kinase I written by Pascal Weinmeister and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Regulation Of Vascular Smooth Muscle Cell Growth By Cyclic Nucleotides And Cgmp Dependent Protein Kinase I
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Author :
language : en
Publisher:
Release Date : 2005
Regulation Of Vascular Smooth Muscle Cell Growth By Cyclic Nucleotides And Cgmp Dependent Protein Kinase I written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
The aim of this work was to elucidate the effect of cyclic nucleotide signaling on the growth of vascular smooth muscle cells (VSMCs). In particular, the role of cGKI in VSMC growth was analysed in primary and subcultured VSMCs derived from wild-type and cGKI-deficient mice. In primary VSMCs, activation of cGMP/cGKI signaling led to a strong increase in growth. In contrast, in repeatedly passaged VSMCs derived from mouse, rat and human, cGMP/cGKI had either no effect on growth or had a weak growth suppressing effect. Thus, cGKI signaling differs in primary vs. subcultured VSMCs. The further analysis of proliferation, apoptosis, cytoskeletal dynamics, and various signaling pathways indicated that an increase in integrin-mediated cell adhesion is the major mechanism for cGKI-mediated growth in primary VSMCs. Thereby, cGMP/cGKI signaling in primary VSMCs might inhibit anoïkis, the programmed cell death induced by the loss of cell/matrix interactions.
The Endothelium
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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Regulation Of Cyclic Gmp Dependent Protein Kinase Expression By Inflammatory Cytokines In Vascular Smooth Muscle Cells
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Author : Natasha Consuela Browner
language : en
Publisher:
Release Date : 2004
Regulation Of Cyclic Gmp Dependent Protein Kinase Expression By Inflammatory Cytokines In Vascular Smooth Muscle Cells written by Natasha Consuela Browner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Post Genomic Cardiology
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Author : José Marín-García
language : en
Publisher: Academic Press
Release Date : 2014-05-09
Post Genomic Cardiology written by José Marín-García and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Medical categories.
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Regulation Of Phenotype In Cultured Vascular Smooth Muscle Cells By Cgmp Dependent Protein Kinase
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Author : Nancy Johnston Boerth
language : en
Publisher:
Release Date : 1996
Regulation Of Phenotype In Cultured Vascular Smooth Muscle Cells By Cgmp Dependent Protein Kinase written by Nancy Johnston Boerth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Cyclic Nucleotide Signaling And The Cardiovascular System
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Author : Thomas Brand
language : en
Publisher: MDPI
Release Date : 2018-07-10
Cyclic Nucleotide Signaling And The Cardiovascular System written by Thomas Brand and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with Electronic books categories.
This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
Transduction Mechanisms In Cellular Signaling
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Author : Edward A. Dennis
language : en
Publisher: Academic Press
Release Date : 2011-04-04
Transduction Mechanisms In Cellular Signaling written by Edward A. Dennis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-04 with Science categories.
Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
The Cyclic Gmp Dependent Protein Kinase Of Vascular Smooth Muscle Sarcolemma
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Author : Kurt Baltensperger
language : en
Publisher:
Release Date : 1989
The Cyclic Gmp Dependent Protein Kinase Of Vascular Smooth Muscle Sarcolemma written by Kurt Baltensperger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
Handbook Of Cell Signaling
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Author : Ralph A. Bradshaw
language : en
Publisher: Academic Press
Release Date : 2009-11-03
Handbook Of Cell Signaling written by Ralph A. Bradshaw and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-03 with Science categories.
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field