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Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast


Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast
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Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast


Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast
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Author : Paul Louis Myers
language : en
Publisher:
Release Date : 1985

Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast written by Paul Louis Myers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Amino acids categories.




Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast


Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast
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Author : Kirk A. Staschke
language : en
Publisher:
Release Date : 2010

Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast written by Kirk A. Staschke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Rapamycin categories.


Two important nutrient sensing and regulatory pathways, the general amino acid control (GAAC) and the target of rapamycin (TOR), participate in the control of yeast growth and metabolism in response to changes in nutrient availability. Starvation for amino acids activates the GAAC through Gcn2p phosphorylation of the translation initiation factor eIF2 and preferential translation of GCN4, a transcription activator. TOR senses nitrogen availability and regulates transcription factors, such as Gln3p. We used microarray analyses to address the integration of the GAAC and TOR pathways in directing the yeast transcriptome during amino acid starvation and rapamycin treatment. We found that the GAAC is a major effector of the TOR pathway, with Gcn4p and Gln3p each inducing a similar number of genes during rapamycin treatment. While Gcn4p activates a common core of 57 genes, the GAAC directs significant variations in the transcriptome during different stresses. In addition to inducing amino acid biosynthetic genes, Gcn4p activates genes required for assimilation of secondary nitrogen sources, such as g-amino-butyric acid (GABA). Gcn2p activation upon shifting to secondary nitrogen sources is suggested to occur by means of a dual mechanism. First, Gcn2p is induced by the release of TOR repression through a mechanism involving Sit4p protein phosphatase. Second, this eIF2 kinase is activated by select uncharged tRNAs, which were shown to accumulate during the shift to GABA medium. This study highlights the mechanisms by which the GAAC and TOR pathways are integrated to recognize changing nitrogen availability and direct the transcriptome for optimal growth adaptation.



General Control Of Amino Acid Biosynthesis In Yeast


General Control Of Amino Acid Biosynthesis In Yeast
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Author : Brian Michael Hauge
language : en
Publisher:
Release Date : 1986

General Control Of Amino Acid Biosynthesis In Yeast written by Brian Michael Hauge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Amino acids categories.




Industrial Aspects Of Biochemistry And Genetics


Industrial Aspects Of Biochemistry And Genetics
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Author : Gurdal N. Alaeddinoglu
language : en
Publisher: Springer
Release Date : 2013-04-05

Industrial Aspects Of Biochemistry And Genetics written by Gurdal N. Alaeddinoglu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-05 with Science categories.


This book includes the proceedings of a NATO Advanced Study Institute held at Cesme (Turkey), from September 4 to 14, 1983. Recent advances in molecular biology have generated a wave of excitement about the prospective application of novel micro­ biological techniques in a wide range of industrial roles. The new methodology, brought about by recombinant DNA technology, has given the biologist direct access to the genome which in turn, envisages the adaption of certain microorganisms to industrial production, much higher yields of such products as antibiotics and enzymes by biotechnological industry, and the industrial production of sub­ stances which occur in nature in very low concentrations and cannot be economically recovered. In the chapters that follow, the accomplishments and the promise of genetic engineering and industrial microbiology are set forth by its practitioners. We greatly acknowledge the help of those in preparation of the individual manuscripts and our thanks to all participants of the meeting for their particular efforts. Nafi G Alaeddinoglu Arnold L Demain Giancarlo C Lancini v CONTENTS Plasmid Incompatibility and Replication . . . . . . . . .. . 1 A. Tolun A Transposable Element from Halobacterium halobium 9 which Inactivates the Bacteriorhodopsin Gene M. ~im~ek Streptomycete Plasmid Cloning Vectors 19 C.J. Thompson and J.E. Davies Genetic Instability in Streptomyces 27 R. Hutter and G. Hintermann Novel Techniques for Breeding of Microorganisms and Application of the Microorganisms to Production of Glutathione . . . . . . . . 35 A. Kimura 49 Amino Acid Overproduction . . . .



Genetics And Biotechnology


Genetics And Biotechnology
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Author : Ulrich Kück
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Genetics And Biotechnology written by Ulrich Kück and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.


Mycology, the study of fungi, originated as a subdiscipline of botany and was a descriptive discipline, largely neglected as an experimental science until the early years of this century. A seminal paper by Blakeslee in 1904 provided evidence for self incompatibility, termed "heterothallism", and stimulated interest in studies related to the control of sexual reproduction in fungi by mating-type specificities. Soon to follow was the demonstration that sexually reproducing fungi exhibit Mendelian inheritance and that it was possible to conduct formal genetic analysis with fungi. The names Burgeff, Kniep and Lindegren are all associated with this early period of fungal genetics research. These studies and the discovery of penicillin by Fleming, who shared a Nobel Prize in 1945, provided further impetus for experimental research with fungi. Thus began a period of interest in mutation induction and analysis of mutants for bio chemical traits. Such fundamental research, conducted largely with Neurospora crassa, led to the one gene: one enzyme hypothesis and to a second Nobel Prize for fungal research awarded to Beadle and Tatum in 1958. Fundamental research in biochemical genetics was extended to other fungi, especially to Saccharomyces cere visiae, and by the mid-1960s fungal systems were much favored for studies in eukaryotic molecular biology and were soon able to compete with bacterial systems in the molecular arena.



Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering


Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering
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Author : Volker F. Wendisch
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-24

Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering written by Volker F. Wendisch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-24 with Science categories.


This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.



Molecular Biology Of The Cell


Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.




Proceedings Of The National Academy Of Sciences Of The United States Of America


Proceedings Of The National Academy Of Sciences Of The United States Of America
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Author :
language : en
Publisher:
Release Date : 2000

Proceedings Of The National Academy Of Sciences Of The United States Of America written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Science categories.




Protein Synthesis And Targeting In Yeast


Protein Synthesis And Targeting In Yeast
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Author : Alistair J.P. Brown
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Protein Synthesis And Targeting In Yeast written by Alistair J.P. Brown and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.


Due to fundamental similarities between the yeast Saccharomyces cerevisiae and multicellular organisms at the molecular level, and the powerful range of experimental tools available for this yeast, S. cerevisiae is proving an ideal model system for studies on protein synthesis and targeting. The topics covered are: - Messenger RNA stability and translation.- The translation apparatus. - Translational control andfidelity. - Protein targeting to the mitochondrion. - Nuclear transport. - The secretory pathway. - Protein folding and degradation. - Protein splicing. Modern and often novel molecular, genetic and biochemical approaches as well as most recent data are provided. The reader will gain a comprehensive view of the current status of the field.



Biochemistry And Molecular Biology


Biochemistry And Molecular Biology
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Author : Robert Brambl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17

Biochemistry And Molecular Biology written by Robert Brambl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.


The Series The fungi represent a heterogeneous assemblage of eukaryotic microorganisms and have become favored organisms for research at the cellular and molecular level. Such research involvement has been stimulated by interest in the biotechnological application of fungi in processes related to industry, agriculture and ecology. Considering both yeasts and mycelial fungi, The Mycota highlights developments in both basic and applied research and presents an overview of fungal systematics and cell structure. Foremost authorities in research on mycology have been assembled to edit and contribute to the volumes. This Volume The third volume includes: Membrane Systems and Transport, Responses to Physical Stress, Transcription, Chromosome Replication, Metabolic Pathways and Regulation.