Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast
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Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast
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Author : Kirk A. Staschke
language : en
Publisher:
Release Date : 2010
Integration Of General Amino Acid Control And Tor Regulatory Pathways In Yeast written by Kirk A. Staschke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Rapamycin categories.
Two important nutrient sensing and regulatory pathways, the general amino acid control (GAAC) and the target of rapamycin (TOR), participate in the control of yeast growth and metabolism in response to changes in nutrient availability. Starvation for amino acids activates the GAAC through Gcn2p phosphorylation of the translation initiation factor eIF2 and preferential translation of GCN4, a transcription activator. TOR senses nitrogen availability and regulates transcription factors, such as Gln3p. We used microarray analyses to address the integration of the GAAC and TOR pathways in directing the yeast transcriptome during amino acid starvation and rapamycin treatment. We found that the GAAC is a major effector of the TOR pathway, with Gcn4p and Gln3p each inducing a similar number of genes during rapamycin treatment. While Gcn4p activates a common core of 57 genes, the GAAC directs significant variations in the transcriptome during different stresses. In addition to inducing amino acid biosynthetic genes, Gcn4p activates genes required for assimilation of secondary nitrogen sources, such as g-amino-butyric acid (GABA). Gcn2p activation upon shifting to secondary nitrogen sources is suggested to occur by means of a dual mechanism. First, Gcn2p is induced by the release of TOR repression through a mechanism involving Sit4p protein phosphatase. Second, this eIF2 kinase is activated by select uncharged tRNAs, which were shown to accumulate during the shift to GABA medium. This study highlights the mechanisms by which the GAAC and TOR pathways are integrated to recognize changing nitrogen availability and direct the transcriptome for optimal growth adaptation.
Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast
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Author : Paul Louis Myers
language : en
Publisher:
Release Date : 1985
Regulatory Genes For General Control Of Amino Acid Biosynthesis In Yeast written by Paul Louis Myers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Amino acids categories.
Structure Function And Regulation Of Tor Complexes From Yeasts To Mammals
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-11-18
Structure Function And Regulation Of Tor Complexes From Yeasts To Mammals written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-18 with Science categories.
This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Biology Of Aminoacyl Trna Synthetases
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-10-23
Biology Of Aminoacyl Trna Synthetases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-23 with Science categories.
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Issues In Biochemistry And Biomaterials 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Issues In Biochemistry And Biomaterials 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.
Issues in Biochemistry and Biomaterials / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biochemistry and Biomaterials. The editors have built Issues in Biochemistry and Biomaterials: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biochemistry and Biomaterials in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Biomaterials / 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
The Enzymes Structure Function And Regulation Of Tor Complexes From Yeasts To Mammals
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Author : Paul D. Boyer
language : en
Publisher:
Release Date : 1970
The Enzymes Structure Function And Regulation Of Tor Complexes From Yeasts To Mammals written by Paul D. Boyer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Enzymes categories.
Ras Family Gtpases
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Author : Channing Der
language : en
Publisher: Springer
Release Date : 2006-09-13
Ras Family Gtpases written by Channing Der and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-13 with Medical categories.
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Yeast Stress Responses
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Author : Stefan Hohmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-23
Yeast Stress Responses written by Stefan Hohmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-23 with Science categories.
Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.
The Unfolded Protein Response And Cellular Stress Part B
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2011-01-22
The Unfolded Protein Response And Cellular Stress Part B written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-22 with Science categories.
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation The authors explain how these methods are able to provide important biological insights
Yeast As A Tool In Cancer Research
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Author : John L Nitiss
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-16
Yeast As A Tool In Cancer Research written by John L Nitiss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-16 with Medical categories.
Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.