Resistance To Anti Cd20 Antibodies And Approaches For Their Reversal
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Resistance To Anti Cd20 Antibodies And Approaches For Their Reversal
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-09-22
Resistance To Anti Cd20 Antibodies And Approaches For Their Reversal written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-22 with Computers categories.
Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal presents in-depth content written by international experts in the study of resistance to anti-CD20 antibodies and approaches for their reversal. Anti-CD20 antibodies are used to achieve B cell depletion and are developed to treat B cell proliferative disorders, including non-Hodgkin's lymphoma and chronic lymphocytic leukemia. In the past two decades, anti-CD20 antibodies have revolutionized the treatment of all B cell malignancies, however, there are patients that fail to respond to initial therapy or relapse sooner. This book explores new and existing avenues surrounding Anti-CD20 antibodies. In recent years, several next-generation anti-CD20 therapies have been developed but predicting and reversing resistance is still a challenging task. These areas are being actively studied as they represent a potential to improve anti-CD20 therapies and are discussed thoroughly in the book. It is a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about resistance to anti-CD20 antibodies and their reversal.
Resistance To Anti Cd20 Antibodies And Approaches For Their Reversal
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-08-30
Resistance To Anti Cd20 Antibodies And Approaches For Their Reversal written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-30 with Computers categories.
Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal presents in-depth content written by international experts in the study of resistance to anti-CD20 antibodies and approaches for their reversal. Anti-CD20 antibodies are used to achieve B cell depletion and are developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. In the past two decades, anti-CD20 antibodies have revolutionized the treatment of all B cell malignancies, however, there are patients that fail to respond to initial therapy or relapse sooner. This book explores new and existing avenues surrounding Anti-CD20 antibodies. In recent years, several next-generation anti-CD20 therapies have been developed but predicting and reversing resistance is still a challenging task. These areas are being actively studied as they represent a potential to improve anti-CD20 therapies and are discussed thoroughly in the book. It is a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about resistance to anti-CD20 antibodies and their reversal. • Presentation of current research, critical analyses, in-depth literature reviews, and the latest clinical reports on anti-CD20 antibody treatment • Discussion of recent developments of anti-CD20 antibodies in cancer and noncancer diseases treatment, possible resistance mechanisms and their reversals, as well as the exciting therapeutic opportunities offered by anti-CD20 antibodies in combination with chemotherapy or other treatment modalities • Utilization of a number of diagrams to visually illustrate complex content and plenty of tables to summarize important information
Novel Sensitizing Agents For Therapeutic Anti Egfr Antibodies
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Author : Shi Hu
language : en
Publisher: Academic Press
Release Date : 2022-11-11
Novel Sensitizing Agents For Therapeutic Anti Egfr Antibodies written by Shi Hu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-11 with Science categories.
Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents a description of the sensitizers used to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs and other sensitizers. The book gives insights into the landscape of anti-EGFR based cancer treatments, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. It offers pertinent science information on strategies used for the rational design and discovery of novel sensitizing agents, and in addition, translational studies involving pre-clinical and clinical design. This book is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists.Finally, the book covers basic science strategies used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology, including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance. Presents detailed descriptions on the history, chemistry, mechanism of action, structure-function relationships, pharmacology, side effects, dosing and formulation of new sensitizers to anti-EGFR antibodies Provides molecular structures for all novel anticancer drugs, along with strategies to overcome resistance to anti-EGFR antibodies Encompasses up-to-date information on the cancer drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in emerging areas of precision medicine
Cancer Associated Fibroblasts Cafs Based Model Reveals Potential For Predicting Bladder Cancer Patients Prognoses And Immunotherapy Responses
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Author : Mengyuan Dong
language : en
Publisher: OAE Publishing Inc.
Release Date : 2024-02-19
Cancer Associated Fibroblasts Cafs Based Model Reveals Potential For Predicting Bladder Cancer Patients Prognoses And Immunotherapy Responses written by Mengyuan Dong and has been published by OAE Publishing Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-19 with Medical categories.
Aim: The purpose of this study is to enhance the understanding of bladder cancer and the role of cancer-associated fibroblasts (CAFs) in its progression. We aim to identify CAF-specific biomarkers and develop a prognostic prediction model based on CAFs, thereby contributing to the advancement of treatment strategies and the identification of prognostic and predictive biomarkers for bladder cancer. Method: We employed single-cell RNA sequencing to detect biomarkers for CAFs in bladder cancer cells. Bladder cancer cohorts were categorized into low- and high-CAF groups using the ssGSEA algorithm. The study also explored the association between CAF-related scores, immune-related cells, and immune checkpoint-related genes. Furthermore, we performed GSVA analysis to understand the biological features of CAFs and their link to various cancer-related pathways. Result: Ten genes were identified as CAF markers in bladder cancer cells. A significant difference was found with 2712 differentially expressed genes between low-CAF and high-CAF tissues. The CAFs-based prognostic prediction model included nine genes (ALDH1L2, AL450384.2, EMP1, LINC02362, WFIKKN1, GOLGA8A, POU5F1, AL354919.2, PTPRR), which are potentially crucial in predicting bladder cancer prognosis. The GSVA analysis revealed the involvement of several cancer-related pathways, such as WNT, toll-like receptor, TGF-beta, MAPK, and MTOR signaling pathways, in the CAFs-based prognostic model. Conclusion: This study highlights the significant role of CAFs in the progression and prognosis of bladder cancer. The identified CAF biomarkers and the constructed prognostic model provide valuable insights for future research and potential therapeutic targets. CAF-dependent pathways are promising for the development of new treatments and improving the prognosis of bladder cancer patients.
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy
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Author : Benjamin Bonavida
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-31
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy written by Benjamin Bonavida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-31 with Medical categories.
This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.
Resistance To Immunotherapeutic Antibodies In Cancer
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Author : Benjamin Bonavida
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-04
Resistance To Immunotherapeutic Antibodies In Cancer written by Benjamin Bonavida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-04 with Medical categories.
The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.
Methods Of Cancer Diagnosis Therapy And Prognosis
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Author : M. A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-04-07
Methods Of Cancer Diagnosis Therapy And Prognosis written by M. A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-07 with Medical categories.
There are more than 100 types of cancers In Part II, head and neck cancer is d- affecting all parts of the human body. cussed. The global number of annual new More than 11 million people are diagnosed cases of this malignancy is ~500,000. These with cancer every year, and it is estimated malignancies include oral squamous cell that there will be 16 million new cases by carcinoma, salivary gland tumors, tons- the year 2020. In 2005, 7. 6 million peo- lar cancer, tongue cancer, nasopharyngeal ple died of cancer, that is, 13% of the 58 carcinoma, and retinoblastoma, which are million deaths worldwide. It is estimated detailed. In Part III, diagnosis, therapy, and that 9 million people will die from can- prognosis of thyroid carcinoma are d- cer worldwide in 2015 and 11. 4 million cussed. The global number of new cases of will die in 2030. More than 70% of all thyroid cancer is ~141,000, and the number cancer deaths occur in low and middle of worldwide thyroid mortalities is ~35,375. income countries. These statistics underlie The number of new cases of this cancer in the fact that cancer is the deadliest of all the United States is ~33,550. Molecular human diseases. The enormity of the glo- genetics of thyroid cancer, gene expr- bal healthcare costs as a result of cancer sion markers for diagnosis, papillary t- cannot be overemphasized.
Neoplastic Diseases Of The Blood
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Author : Peter H. Wiernik
language : en
Publisher: Cambridge University Press
Release Date : 2003-06-09
Neoplastic Diseases Of The Blood written by Peter H. Wiernik and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-09 with Medical categories.
In this fourth edition of the classic work on malignant blood cancers, the team of editors and over 100 international leaders in the field provide a comprehensive text on the diagnosis and treatment of all hematologic malignancies, both common and rare. The sixty-two chapters are divided into sections on Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, Lymphomas, and Supportive Care, with a devoted editor for each section. This extensively revised and updated edition reflects the tremendous progress in the science and treatment of hematologic malignancies during the eight years since the third edition in 1995. Revisions and new chapters include coverage of stem cell transplantation, molecular genetics, monoclonal antibodies, and new treatment modalities. The excellent discussions of current therapies for all hematologic neoplasms are more detailed than those in general oncology or hematology texts, making this an essential reference for all hematologists and oncologists.
Reversal Of Drug Resistance In Non Hodgkin S Lymphoma By Immunotherapy
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Author : Steve Anthony Alas
language : en
Publisher:
Release Date : 2000
Reversal Of Drug Resistance In Non Hodgkin S Lymphoma By Immunotherapy written by Steve Anthony Alas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Translational Neuroimmunology In Multiple Sclerosis
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Author : Ruth Arnon
language : en
Publisher: Academic Press
Release Date : 2016-05-10
Translational Neuroimmunology In Multiple Sclerosis written by Ruth Arnon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-10 with Science categories.
Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology