Reviews On New Drug Targets In Age Related Disorders
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Reviews On New Drug Targets In Age Related Disorders
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Author : Paul C. Guest
language : en
Publisher: Springer Nature
Release Date : 2021-03-16
Reviews On New Drug Targets In Age Related Disorders written by Paul C. Guest and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-16 with Science categories.
Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.
Reviews On New Drug Targets In Age Related Disorders
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Author : Paul C. Guest
language : en
Publisher:
Release Date : 2021
Reviews On New Drug Targets In Age Related Disorders written by Paul C. Guest and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Drug targeting categories.
Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in 'omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from 'omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest's previous book Reviews on New Drug Targets in Age-Related Disorders.
Reviews On New Drug Targets In Age Related Disorders
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Author : Paul C. Guest
language : en
Publisher: Springer Nature
Release Date : 2020-04-17
Reviews On New Drug Targets In Age Related Disorders written by Paul C. Guest and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Science categories.
Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.
Studies On Biomarkers And New Targets In Aging Research In Iran
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Author : Paul C. Guest
language : en
Publisher: Springer Nature
Release Date : 2021-07-31
Studies On Biomarkers And New Targets In Aging Research In Iran written by Paul C. Guest and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-31 with Science categories.
The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan. This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research. The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases.
Anti Aging Drugs
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Author : Alexander M Vaiserman
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-01-18
Anti Aging Drugs written by Alexander M Vaiserman and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Medical categories.
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Drug Design And Discovery In Alzheimer S Disease
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Author : Atta-ur-Rahman
language : en
Publisher: Elsevier
Release Date : 2015-06-27
Drug Design And Discovery In Alzheimer S Disease written by Atta-ur-Rahman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-27 with Science categories.
Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
Introductory Review On Sirtuins In Biology Aging And Disease
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Author : Leonard Guarente
language : en
Publisher: Academic Press
Release Date : 2018-04-20
Introductory Review On Sirtuins In Biology Aging And Disease written by Leonard Guarente and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-20 with Science categories.
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses
Improving And Accelerating Therapeutic Development For Nervous System Disorders
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2014-02-06
Improving And Accelerating Therapeutic Development For Nervous System Disorders written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-06 with Medical categories.
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
New Drug Targets For Proteotoxicity In Cardiometabolic Diseases
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Author : Jun Ren
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-02
New Drug Targets For Proteotoxicity In Cardiometabolic Diseases written by Jun Ren and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-02 with Science categories.
Immunomodulators In Aquaculture And Fish Health
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Author : Preetham Elumalai
language : en
Publisher: CRC Press
Release Date : 2023-10-31
Immunomodulators In Aquaculture And Fish Health written by Preetham Elumalai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-31 with Technology & Engineering categories.
This reference book provides updated information about different immunomodulators for managing fish health and sustainable aquaculture. Immunomodulators are dietary additives that enhance innate defense mechanisms and increase resistance against specific pathogens and diseases. The book covers the different types of immunostimulants, their modes of action, and their efficacies. It also reviews safety concerns, ethical regulations, limitations, and outreach to farmers. It discusses the application of herbal immunomodulators, antioxidants, pre- and pro-biotics, in disease management. Features: • Reviews the pressing topic of reduction of antibiotic use in aquaculture • Discusses herbal immunomodulators, nutrients, antioxidants and pre- and pro-biotics • Covers the topic of progressive immunomodulation using nanotechnology • Discusses fish health management in the ever-growing aquaculture industry • Includes natural and synthetic immunomodulators The book is meant for researchers and industry experts in aquaculture, fisheries science, and veterinary medicine.