Rigor And Structure
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Rigor And Structure
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Author : John P. Burgess
language : en
Publisher: OUP Oxford
Release Date : 2015-02-12
Rigor And Structure written by John P. Burgess and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-12 with Philosophy categories.
While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental mathematics on the one hand and computerized formal proofs on the other hand. The main theses of Rigor and Structure are that the features of mathematical practice that a large group of philosophers of mathematics, the structuralists, have attributed to the peculiar nature of mathematical objects are better explained in a different way, as artefacts of the manner in which the ancient ideal of rigor is realized in modern mathematics. Notably, the mathematician must be very careful in deriving new results from the previous literature, but may remain largely indifferent to just how the results in the previous literature were obtained from first principles. Indeed, the working mathematician may remain largely indifferent to just what the first principles are supposed to be, and whether they are set-theoretic or category-theoretic or something else. Along the way to these conclusions, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed.
Myosins
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Author : Lynne M. Coluccio
language : en
Publisher: Springer Nature
Release Date : 2020-05-25
Myosins written by Lynne M. Coluccio and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-25 with Science categories.
This highly authoritative volume highlights the remarkable superfamily of molecular motors called myosins, which are involved in such diverse cellular functions as muscle contraction, intracellular transport, cell migration and cell division. In a timely compilation of chapters written by leading research groups that have made key discoveries in the field, the current understanding of the molecular mechanisms and biological functions of these intriguing proteins is explored.
The Structural Basis Of Muscular Contraction
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Author : John Squire
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Structural Basis Of Muscular Contraction written by John Squire and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Muscular contraction provides one of the most fascinating topics for a biophysicist to study. Although muscle comprises a molecular machine whereby chemical energy is converted to mechanical work, its action in producing force is something that is readily observable in everyday life, a feature that does not apply to most other structures of biophysical inter est. In addition, muscle is so beautifully organized at the microscopic level that those important structural probes, electron microscopy (with the associated image analysis methods) and X-ray diffraction, have pro vided a wealth of information about the arrangements of the constituent proteins in a variety of muscle types. But, despite all this, the answer to the question "How does muscle work?" is still uncertain, especially with regard to the molecular events by which force is actually generated, and the question remains one of the major unsolved problems in biology. With this problem in mind, this book has been written to collect together the available evidence on the structures of the muscle fila ments and on their arrangements in different muscle cells, to extract the common structural features of these cells, and thus to attempt to define a possible series of mechanical steps that will describe at molecular resolu tion the process by which force is generated. The book cannot be considered to be an introductory text; in fact, it presents a very detailed account of muscle structure as gleaned mainly from electron microscopy and X-ray diffraction.
Integrative Structural Biology With Hybrid Methods
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Author : Haruki Nakamura
language : en
Publisher: Springer
Release Date : 2019-01-08
Integrative Structural Biology With Hybrid Methods written by Haruki Nakamura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-08 with Science categories.
This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested inthis book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.
Structures A Studio Approach
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Author : Edmond Saliklis
language : en
Publisher: Springer Nature
Release Date : 2020-03-02
Structures A Studio Approach written by Edmond Saliklis and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-02 with Technology & Engineering categories.
Understanding how gravity loads and wind and earthquake loads flow through a building is of utmost importance to all structural engineers and architects. Paradoxically, this critical idea is practically not addressed in any textbook on the market. Meant as a companion to the author’s Structures: A Geometric Approach, this textbook fills that need with qualitative techniques as well as quantitative tools that use state of the art visual representation of forces and deformations in structures. Structures: A Studio Approach reaches out to both structural engineers and designers by presenting structural engineering topics in an interdisciplinary studio environment. Using many graphical techniques, it offers a very rigorous approach, but also enables creativity. Cutting edge finite element as well as parametric modeling tools are used, and state of the art visual representations of force flow help both groups of students realize that understanding three dimensional load flow in a building is a requirement for channeling that flow in a structurally efficient and visually expressive manner. Ultimately, the reader is able to develop a unique structural sensibility; an ethos that places structural design on an equal footing with the design of program, skin, massing and site.
From Protein Structure To Function With Bioinformatics
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Author : Daniel John Rigden
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-11
From Protein Structure To Function With Bioinformatics written by Daniel John Rigden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-11 with Science categories.
Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.
The Structure And Function Of Muscle
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Author : Geoffrey Howard Bourne
language : en
Publisher:
Release Date : 1960
The Structure And Function Of Muscle written by Geoffrey Howard Bourne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1960 with Muscles categories.
From Protein Structure To Function With Bioinformatics
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Author : Daniel J. Rigden
language : en
Publisher: Springer
Release Date : 2017-04-06
From Protein Structure To Function With Bioinformatics written by Daniel J. Rigden and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-06 with Science categories.
This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins. The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously. This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.
Mechanisms Of Work Production And Work Absorption In Muscle
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Author : Haruo Sugi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Work Production And Work Absorption In Muscle written by Haruo Sugi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
`In contrast to common practice, we have always tried to include as many discussions held at the meeting in our proceedings as possible, so as to enable readers to properly evaluate each paper presented, as well as to learn of future prospects in this field of research. Although the policy of including discussions occasions a long publication delay, we believe that it is worth repeating in our future publication, as we have met a number of young investigators fascinated by the discussions in our proceedings.... In the concluding remarks in this volume, Dr. Hugh E. Huxley, a principal architect of the sliding filament mechanism of muscle contraction, states that the molecular mechanism of myofilament sliding remains mysterious to all of us. We hope that this volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle contraction.' Haruo Sugi and Gerald H. Pollack, excerpted from the Preface.
Structure
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Author :
language : en
Publisher:
Release Date : 2007
Structure written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Biomolecules categories.