Rna Folding
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Rna Folding
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Author : Ronny Lorenz
language : en
Publisher: Springer Nature
Release Date :
Rna Folding written by Ronny Lorenz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Biophysics Of Rna Folding
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Author : Rick Russell
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
Biophysics Of Rna Folding written by Rick Russell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Science categories.
This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
Rna Structure And Folding
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Author : Dagmar Klostermeier
language : en
Publisher: Walter de Gruyter
Release Date : 2013-10-14
Rna Structure And Folding written by Dagmar Klostermeier and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-14 with Science categories.
While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.
Rna Folding
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Author : Christina Waldsich
language : en
Publisher:
Release Date : 2014
Rna Folding written by Christina Waldsich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with RNA categories.
Focusing on in vitro and intracellular RNA structure formation, RNA Folding: Methods and Protocols provides a comprehensive collection of experimental protocols which are suitable to dissect RNA folding pathways and to characterize the structure of RNA folding intermediates at nucleotide or even atomic resolution. The presented techniques include powerful tools with a long tradition in RNA research as well as more advanced, novel methods, thus the methods span multiple disciplines, including molecular biology, biochemistry, biophysics, and computational biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, RNA Folding: Methods and Protocols serves as a vital reference for researchers attempting to gain insights into the secrets of this astounding macromolecule.
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding
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Author : Daniel Herschlag
language : en
Publisher: Academic Press
Release Date : 2009-11-16
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding written by Daniel Herschlag and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Science categories.
This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. Expert researchers introduce the most advanced technologies and techniques in protein structure and folding Includes techniques on tiling assays
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part B
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Author : Daniel Herschlag
language : en
Publisher: Academic Press
Release Date : 2009-11-16
Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding Part B written by Daniel Herschlag and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-16 with Science categories.
This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. Expert researchers introduce the most advanced technologies and techniques in protein structure and folding Includes techniques on tiling assays
Rna Structure Prediction
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Author : Risa Karakida Kawaguchi
language : en
Publisher: Springer Nature
Release Date : 2023-01-27
Rna Structure Prediction written by Risa Karakida Kawaguchi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-27 with Science categories.
This book explores recent progress in RNA secondary, tertiary structure prediction, and its application from an expansive point of view. Because of advancements in experimental protocols and devices, the integration of new types of data as well as new analysis techniques is necessary, and this volume discusses additional topics that are closely related to RNA structure prediction, such as the detection of structure-disrupting mutations, high-throughput structure analysis, and 3D structure design. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to quality research results. Authoritative and practical, RNA Structure Prediction serves as a valuable guide for both experimental and computational RNA researchers.
Rna 3d Structure Analysis And Prediction
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Author : Neocles Leontis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-05
Rna 3d Structure Analysis And Prediction written by Neocles Leontis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Science categories.
With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
Markov State Models For Protein And Rna Folding
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Author : Gregory Ross Bowman
language : en
Publisher: Stanford University
Release Date : 2010
Markov State Models For Protein And Rna Folding written by Gregory Ross Bowman and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Understanding the molecular bases of human health could greatly augment our ability to prevent and treat diseases. For example, a deeper understanding of protein folding would serve as a reference point for understanding, preventing, and reversing protein misfolding in diseases like Alzheimer's. Unfortunately, the small size and tremendous flexibility of proteins and other biomolecules make it difficult to simultaneously monitor their thermodynamics and kinetics with sufficient chemical detail. Atomistic Molecular Dynamics (MD) simulations can provide a solution to this problem in some cases; however, they are often too short to capture biologically relevant timescales with sufficient statistical accuracy. We have developed a number of methods to address these limitations. In particular, our work on Markov State Models (MSMs) now makes it possible to map out the conformational space of biomolecules by combining many short simulations into a single statistical model. Here we describe our use of MSMs to better understand protein and RNA folding. We chose to focus on these folding problems because of their relevance to misfolding diseases and the fact that any method capable of describing such drastic conformational changes should also be applicable to less dramatic but equally important structural rearrangements like allostery. One of the key insights from our folding simulations is that protein native states are kinetic hubs. That is, the unfolded ensemble is not one rapidly mixing set of conformations. Instead, there are many non-native states that can each interconvert more rapidly with the native state than with one another. In addition to these general observations, we also demonstrate how MSMs can be used to make predictions about the structural and kinetic properties of specific systems. Finally, we explain how MSMs and other enhanced sampling algorithms can be used to drive efficient sampling.
High Resolution Single Molecule Measurements Of Transcription And Rna Folding
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Author : William James Greenleaf
language : en
Publisher:
Release Date : 2007
High Resolution Single Molecule Measurements Of Transcription And Rna Folding written by William James Greenleaf and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.