Rna Modifications And Epitranscriptomics Volume Ii

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Rna Modifications And Epitranscriptomics Volume Ii

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Author : Giovanni Nigita
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-30

Rna Modifications And Epitranscriptomics Volume Ii written by Giovanni Nigita and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Science categories.

Applications Of Rna Seq And Omics Strategies

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Author : Fabio Marchi
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-09-13

Applications Of Rna Seq And Omics Strategies written by Fabio Marchi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-13 with Medical categories.

The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.

Rna Modifications And Epitranscriptomics

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Author : Xiao Han
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05

Rna Modifications And Epitranscriptomics written by Xiao Han and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Science categories.

Epitranscriptomics

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Author : Stefan Jurga
language : en
Publisher: Springer Nature
Release Date : 2021-07-28

Epitranscriptomics written by Stefan Jurga and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.

This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

Computational Epigenomics And Epitranscriptomics

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Author : Pedro H. Oliveira
language : en
Publisher: Springer Nature
Release Date : 2023-02-01

Computational Epigenomics And Epitranscriptomics written by Pedro H. Oliveira and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-01 with Science categories.

This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.

Biology Of Archaea Volume 2

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Author : Béatrice Clouet-d'Orval
language : en
Publisher: John Wiley & Sons
Release Date : 2025-04-29

Biology Of Archaea Volume 2 written by Béatrice Clouet-d'Orval and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-29 with Science categories.

Archaea constitute a new branch of life alongside bacteria and eukaryotes. These microorganisms are unique in their cellular and molecular aspects. They have evolutionary links with the first eukaryotic cells and are now being used to elucidate fundamental biological questions. Champions of extremophilicity, archaea are helping to lift the veil on the limits of life on Earth. Biology of Archaea 2 presents the diverse molecular mechanisms involved in the fundamental processes of genome maintenance and regulation of gene expression in archaeal cells. This book analyzes the complex machinery involved in chromosome replication, DNA repair, RNA synthesis (transcription) and protein synthesis (translation), and explores the different classes of RNAs and enzymes involved in RNA maturation and degradation. These regulate the stability of messenger and regulatory non-coding RNAs, and contribute to the formation of the mature forms of ribosomal RNAs and transfer RNAs. These molecular mechanisms are closely related to those of eukaryotes.

Epitranscriptomics The Novel Rna Frontier

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Author : Giovanni Nigita
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-31

Epitranscriptomics The Novel Rna Frontier written by Giovanni Nigita and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-31 with categories.

Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.

Protein Rna Interplay Regulated Signaling In Stem Cells And Cancer

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Author : Liang Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-02

Protein Rna Interplay Regulated Signaling In Stem Cells And Cancer written by Liang Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-02 with Science categories.

Ovarian Cancer Targeted Medication Parp Inhibitors Anti Angiogenic Drugs Immunotherapy And More Volume Ii

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Author : Zhaoqian Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-21

Ovarian Cancer Targeted Medication Parp Inhibitors Anti Angiogenic Drugs Immunotherapy And More Volume Ii written by Zhaoqian Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-21 with Science categories.

Ovarian cancer is the malignancy with the highest rate of death from tumors of the female reproductive system and the main treatment options are tumor reduction and post-surgical platinum-based chemotherapy. Unfortunately, some patients will develop platinum resistance after multiple recurrences. Given that ovarian cancer is a heterogeneous disease with complex molecular and genetic alterations, the identification of specific molecular targets will be of great benefit in gaining a deeper understanding of the mechanisms of ovarian cancer development and progression. As research into targeted therapies continues, the treatment of ovarian cancer is gradually shifting from conventional chemotherapy to targeted therapies. Targeted drugs such as PARP inhibitors and anti-angiogenic drugs have become important modalities for the maintenance treatment of ovarian cancer. At the same time, targeted therapy also suffers from ineffective use, high rates of adverse reactions and high prices. With the development of next-generation sequencing technology, targeted therapeutic agents developed for specific molecules in ovarian cancer may provide a wider range of treatment options for ovarian cancer patients and offer new strategies for individualized treatment. Immunotherapy, as well as ferroptosis pathway modulation, has also provided new ideas for targeted therapy in ovarian cancer.

Biochemical And Molecular Pharmacology In Drug Discovery

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Author : Mithun Rudrapal
language : en
Publisher: Elsevier
Release Date : 2024-06-26

Biochemical And Molecular Pharmacology In Drug Discovery written by Mithun Rudrapal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-26 with Medical categories.

Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches along with certain key topics related to molecular pharmacology of drugs and therapeutics. Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology. It explains the phenomena of drug-target interactions considering different biochemical systems and cellular strategies. With the advent of technologies, current advances and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will be able to gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology, in a comprehensive and systematic manner with special reference to recent advances in drug discovery research. - Highlights the fundamentals of biochemical and molecular aspects, with reference to drug discovery research - Depicts modern drug discovery approaches such as reverse pharmacology, drug repositioning, and CADD in the context of current research updates - Summarizes recent developments in the molecular pharmacology of novel drugs/ therapeutic molecules