Rnai Technologies
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Rnai Technologies
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Author : Prerna Pandey
language : en
Publisher: Delve Publishing
Release Date : 2017-11
Rnai Technologies written by Prerna Pandey and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11 with Gene silencing categories.
RNA interference (RNAi), one of the most exciting discoveries of the last decade, is also known as Post-Transcriptional Gene Silencing (PTGS). It is a conserved host defense response via double-stranded RNA against both endogenous and foreign nucleic acids, and occurs at the levels of transcription, post-transcription and translation. RNA induced gene silencing has been used, with considerable success as a reverse genetics tool for the study of gene function. This technology has revolutionized the gene expression analysis studies because of the specificity and speed it offers. The small RNA molecules central to RNAi are microRNA (miRNA) and small interfering RNA (siRNA). These molecules bind to other RNAs specifically, such as messenger RNA (mRNA), to regulate their activities.In this book, we will discuss how gene silencing methodology has been successfully applied as therapeutic tool against metabolic disorders, cancer, and infectious diseases. This tool has also been successfully used to improve crops resistance against plant pathogens. In contrast to conventional knock-out mutagenesis techniques, the "gene-silencing" vectors, that allow the study of functions of genes whose complete knock-out would otherwise be lethal to the plant.
Rnai Technology
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Author : R. K. Gaur
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Rnai Technology written by R. K. Gaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Science categories.
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Rna Technologies And Their Applications
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Author : Volker A. Erdmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-02
Rna Technologies And Their Applications written by Volker A. Erdmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-02 with Medical categories.
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Advanced Delivery And Therapeutic Applications Of Rnai
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Author : Kun Cheng
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-19
Advanced Delivery And Therapeutic Applications Of Rnai written by Kun Cheng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-19 with Science categories.
Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.
Advances And Challenges Of Rnai Based Technologies For Plants
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Author : Susana Araújo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-28
Advances And Challenges Of Rnai Based Technologies For Plants written by Susana Araújo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.
Rna Interference
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Author : David R. Engelke
language : en
Publisher: Elsevier
Release Date : 2005-02-28
Rna Interference written by David R. Engelke and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-28 with Science categories.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent. * One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences
Rna Interference Technology
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2005-01-17
Rna Interference Technology written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-17 with Science categories.
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Rna Interference
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Author : Dr. Tim Doran
language : en
Publisher: CABI
Release Date : 2009
Rna Interference written by Dr. Tim Doran and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
This methods manual provides an introduction to RNA interference, the theory behind its many applications, and specific protocols for RNAi, in organisms from plants and C.elegans to Drosophila and mammals. There are also chapters covering small hairpin RNAs and viral-induced gene silencing.
Rna Interference And Crispr Technologies
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Author : Mouldy Sioud
language : en
Publisher: Humana
Release Date : 2020-02-01
Rna Interference And Crispr Technologies written by Mouldy Sioud and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-01 with Medical categories.
This volume explores the uses of RNAi and CRISPR interferences as a general method for inhibiting gene expression, with focus on their biological functions, design, chemical modifications, delivery, and preclinical/clinical applications. In addition to relevant backgrounds, the chapters in this book discuss simple and accurate protocols dealing with the latest advances in RNAi and CRISPR applications and look at how these methods differ from one another. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, RNA Interference and CRISPR Technologies: Technical Advances and New Therapeutic Opportunities is a valuable resource for any scientist, teachers, graduate student, postdoc, and clinician interested in this field. This book also benefits anyone in research and development in biotech and pharmaceutical companies who want to understand more about these technologies, and their applications in biology and medicine.
Modulating Gene Expression
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Author : Aditi Singh
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-05-29
Modulating Gene Expression written by Aditi Singh and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-29 with Medical categories.
RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.