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Role Of Neuropilin 1 In Cd8 T Cells


Role Of Neuropilin 1 In Cd8 T Cells
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Role Of Neuropilin 1 In Cd8 T Cells


Role Of Neuropilin 1 In Cd8 T Cells
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Author : Mike Barnkob
language : en
Publisher:
Release Date : 2018

Role Of Neuropilin 1 In Cd8 T Cells written by Mike Barnkob and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.




The Neuropilins Role And Function In Health And Disease


The Neuropilins Role And Function In Health And Disease
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Author : Gera Neufeld
language : en
Publisher: Springer
Release Date : 2017-02-06

The Neuropilins Role And Function In Health And Disease written by Gera Neufeld and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-06 with Medical categories.


This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.



Tissue Resident Memory T Cells


Tissue Resident Memory T Cells
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Author : Fathia Mami-Chouaib
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-19

Tissue Resident Memory T Cells written by Fathia Mami-Chouaib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with categories.


Tissue-resident memory T (TRM) cells play a major role in control of viral infections. Their involvement in cancer diseases has been more recently demonstrated. This non-circulating T-lymphocyte subset lacks molecules enabling egress from the tissue and migration to lymph nodes, expresses specific markers of residency and displays specific transcription factors. The present special issue elucidates our current knowledge on CD8+ TRM cells and explores less frequently described resident subsets, such as CD4+ TRM and innate-like cells, as well as their specific metabolism and niches for their formation in infectious and cancer diseases.



Neuropilin


Neuropilin
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Author : Dominique Bagnard
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-27

Neuropilin written by Dominique Bagnard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-27 with Medical categories.


Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depends on both cell surface adhesion properties and acti vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.



Biology Of T Cells


Biology Of T Cells
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-09-24

Biology Of T Cells written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-24 with Science categories.


Biology of T Cells: Part A, Volume 341, the latest release in the International Review of Cell and Molecular Biology, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists. Specialized topics in this release include TCR signaling: Molecules and mechanisms, TCR diversity: Purpose and generation, Transcriptional programs underlying T-cell differentiation and function, Surface phenotypes of CD8+ and CD4+ T cells, Co-stimulation and co-inhibition in CD8+ and CD4+ T cells, Regulated cell death and T cells, Molecular mechanisms behind T-cell priming by DCs, and more. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects



Signaling Mechanisms Regulating T Cell Diversity And Function


Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27

Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.


T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.



Diverse Functions Of Mucosal Resident Memory T Cells


Diverse Functions Of Mucosal Resident Memory T Cells
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Author : Kimberly Sue Schluns
language : en
Publisher: Frontiers Media SA
Release Date : 2015-06-01

Diverse Functions Of Mucosal Resident Memory T Cells written by Kimberly Sue Schluns and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Immunologic diseases. Allergy categories.


Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites.



Tumor Vessels As Directors Of The Tumor Microenvironment New Findings Current Challenges Perspectives


Tumor Vessels As Directors Of The Tumor Microenvironment New Findings Current Challenges Perspectives
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Author : Lucas Treps
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-22

Tumor Vessels As Directors Of The Tumor Microenvironment New Findings Current Challenges Perspectives written by Lucas Treps and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-22 with Science categories.




Principles Of Mucosal Immunology


Principles Of Mucosal Immunology
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Author : Phillip Smith
language : en
Publisher: Garland Science
Release Date : 2020-04-21

Principles Of Mucosal Immunology written by Phillip Smith and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-21 with Medical categories.


This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.



Generating And Sustaining Stable Autoantigen Specific Cd4 And Cd8 Regulatory T Cells In Lupus


Generating And Sustaining Stable Autoantigen Specific Cd4 And Cd8 Regulatory T Cells In Lupus
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Author : Syamal Kumar Datta
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-19

Generating And Sustaining Stable Autoantigen Specific Cd4 And Cd8 Regulatory T Cells In Lupus written by Syamal Kumar Datta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-19 with Medical categories.