The Neuropilins Role And Function In Health And Disease
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The Neuropilins Role And Function In Health And Disease
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Author : Gera Neufeld
language : en
Publisher: Springer
Release Date : 2017-02-06
The Neuropilins Role And Function In Health And Disease written by Gera Neufeld and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-06 with Medical categories.
This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
New Approaches To Classification And Diagnostic Prediction Of Breast Cancers
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Author : Aleix Prat
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-16
New Approaches To Classification And Diagnostic Prediction Of Breast Cancers written by Aleix Prat and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with categories.
Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2. The main reason is that many promising biomarkers are clinically validated but lack analytical and clinical utility. One explanation is that proper validation of the predictive ability of the biomarker in independent datasets, and with a pre-planned statistical analysis, is not always performed. Thus, there is a need to identify new biomarkers or new ways to subclassify breast cancer patients that are reproducible and easy to implement in the clinical setting but, more importantly, that improve patient’s outcomes.
Molecular Mechanisms And Pathways In Cerebellar Function
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Author : Catarina Osorio
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-21
Molecular Mechanisms And Pathways In Cerebellar Function written by Catarina Osorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-21 with Science categories.
Endothelial Dynamics In Health And Disease
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Author : Jaap Diederik Van Buul
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-06
Endothelial Dynamics In Health And Disease written by Jaap Diederik Van Buul and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-06 with Science categories.
Non Neuronal Cell Heterogeneity In The Nervous System During Health And Disease
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Author : Jason R. Plemel
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-05
Non Neuronal Cell Heterogeneity In The Nervous System During Health And Disease written by Jason R. Plemel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-05 with Science categories.
Receptor Endocytosis And Signalling In Health And Disease Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-01-09
Receptor Endocytosis And Signalling In Health And Disease Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-09 with Science categories.
Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Molecular Biology and Translational Science series Includes the latest information on Receptor Endocytosis and Signaling in Health and Disease
Lung Inflammation In Health And Disease Volume Ii
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Author : Yong-Xiao Wang
language : en
Publisher: Springer Nature
Release Date : 2021-05-21
Lung Inflammation In Health And Disease Volume Ii written by Yong-Xiao Wang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-21 with Medical categories.
Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
The Blood Brain Barrier In Health And Disease Volume One
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Author : Katerina Dorovini-Zis
language : en
Publisher: CRC Press
Release Date : 2015-06-23
The Blood Brain Barrier In Health And Disease Volume One written by Katerina Dorovini-Zis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-23 with Medical categories.
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into
Angiogenesis Lymphangiogenesis And Clinical Implications
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Author : G. Marone
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-10-21
Angiogenesis Lymphangiogenesis And Clinical Implications written by G. Marone and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-21 with Medical categories.
Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.
Retinal Pigment Epithelium In Health And Disease
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Author : Alexa Karina Klettner
language : en
Publisher: Springer Nature
Release Date : 2020-01-01
Retinal Pigment Epithelium In Health And Disease written by Alexa Karina Klettner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-01 with Medical categories.
This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.