Role Of Rna In Molecular Diagnostics Of Cancer
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Role Of Rna In Molecular Diagnostics Of Cancer
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Author : Cesar Wong
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-01
Role Of Rna In Molecular Diagnostics Of Cancer written by Cesar Wong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-01 with categories.
Nucleic Acids As Molecular Diagnostics
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Author : Andreas Keller
language : en
Publisher: John Wiley & Sons
Release Date : 2015-01-12
Nucleic Acids As Molecular Diagnostics written by Andreas Keller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-12 with Science categories.
By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.
Principles Of Molecular Diagnostics And Personalized Cancer Medicine
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Author : Dongfeng Tan
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-12-07
Principles Of Molecular Diagnostics And Personalized Cancer Medicine written by Dongfeng Tan and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-07 with Medical categories.
The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
Rna And Cancer
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Author : Jane Y. Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Rna And Cancer written by Jane Y. Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.
Molecular Diagnostics Of Cancer
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Author : Pier Paolo Piccaluga
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-04-10
Molecular Diagnostics Of Cancer written by Pier Paolo Piccaluga and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-10 with Science categories.
Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease.
Molecular Pathology And Diagnostics Of Cancer
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Author : Domenico Coppola
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-29
Molecular Pathology And Diagnostics Of Cancer written by Domenico Coppola and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-29 with Medical categories.
Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
Clinical Applications Of Noncoding Rnas In Cancer
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Author : Subash Gupta
language : en
Publisher: Academic Press
Release Date : 2022-01-19
Clinical Applications Of Noncoding Rnas In Cancer written by Subash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-19 with Science categories.
Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference
Rna And Dna Diagnostics
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Author : Volker A. Erdmann
language : en
Publisher: Springer
Release Date : 2015-06-10
Rna And Dna Diagnostics written by Volker A. Erdmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-10 with Medical categories.
The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”
Non Coding Rnas In Colorectal Cancer
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Author : Ondrej Slaby
language : en
Publisher: Springer
Release Date : 2016-08-29
Non Coding Rnas In Colorectal Cancer written by Ondrej Slaby and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-29 with Medical categories.
This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.
Molecular Diagnostics Of Pediatric Cancer
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Author : Jing He
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-08
Molecular Diagnostics Of Pediatric Cancer written by Jing He and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-08 with Medical categories.