Roles Of Pan Cell Death Of Tumor Cells In Regulating Tumor Immune Microenvironment

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Roles Of Pan Cell Death Of Tumor Cells In Regulating Tumor Immune Microenvironment

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Author : Jianzhong Ai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-27

Roles Of Pan Cell Death Of Tumor Cells In Regulating Tumor Immune Microenvironment written by Jianzhong Ai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-27 with Medical categories.

The Role Of Non Coding Rnas In Gastrointestinal Cancers

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Author : Kanjoormana Aryan Manu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-08

The Role Of Non Coding Rnas In Gastrointestinal Cancers written by Kanjoormana Aryan Manu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-08 with Medical categories.

Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type. Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.

The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment

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Author : Yanyan Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-14

The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment written by Yanyan Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-14 with Science categories.

Epitranscriptomic Rna Modification In Non Apoptotic Forms Of Regulated Cell Death

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Author : Xing Niu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-29

Epitranscriptomic Rna Modification In Non Apoptotic Forms Of Regulated Cell Death written by Xing Niu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-29 with Science categories.

Crosstalk In Ferroptosis Immunity Inflammation

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Author : Qi Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-17

Crosstalk In Ferroptosis Immunity Inflammation written by Qi Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-17 with Medical categories.

Ferroptosis represents a critical form of regulated cell death, notable for its reliance on iron and its triggering by lipid peroxidation. The process becomes particularly significant in the context of inflammation, a crucial bodily response intended to tackle various threats and ensure tissue equilibrium. Issues arise when inflammation is uncontrolled, leading towards immune dysfunction and cellular demise. Current studies have further postulated that inflammation may instigate ferroptosis, releasing damage-associated molecular patterns (DAMPs) that activate the immune response and exacerbate inflammation. This bi-directional relationship highlights a complex interplay where ferroptosis and inflammation are both cause and consequence. This Research Topic aims to delineate the complex interactions between ferroptosis and inflammation, uncovering how this nexus influences disease treatment, particularly in inflammatory diseases and cancers. We intend to dissect the interaction between ferroptosis and various immune cells and assess ferroptosis's role in conditions like infection, inflammation, and cancer. These insights are anticipated to reveal novel therapeutic avenues and advance the development of targeted medicinal interventions.

Deciphering The Regulatory Role Of Transcription Factors In Cancer Immune Infiltration

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Author : Qian Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-18

Deciphering The Regulatory Role Of Transcription Factors In Cancer Immune Infiltration written by Qian Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-18 with Medical categories.

Transcription factors (TF) are proteins that bind to specific DNA sequences and regulate the transcription of target genes. They control various cellular processes, including cell proliferation, differentiation, and immune responses. In cancer, dysregulated TF activity can profoundly impact the tumor microenvironment, influencing immune cell recruitment, activation, and function. By modulating the expression of immune-related genes, TFs can either promote or suppress immune infiltration in the tumor, shaping the anti-tumor immune response. Cancer immune infiltration, the process by which immune cells infiltrate tumor tissues, is a critical aspect of the tumor microenvironment and plays a pivotal role in cancer progression and response to therapy. Understanding the regulatory role of TFs in cancer immune infiltration holds significant promise for the development of novel therapeutic strategies and biomarkers for cancer treatment.

The Roles Of Ion Induced Cell Death In Cancer Treatment

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Author : Zhijie Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-30

The Roles Of Ion Induced Cell Death In Cancer Treatment written by Zhijie Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Science categories.

Computational Methods For Multi Omics Data Analysis In Cancer Precision Medicine

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Author : Ehsan Nazemalhosseini-Mojarad
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-02

Computational Methods For Multi Omics Data Analysis In Cancer Precision Medicine written by Ehsan Nazemalhosseini-Mojarad and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Science categories.

Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.

Advances In Molecular Biology Knowledge Of Rectal Cancer And Forthcoming Role Of Liquid Biopsy

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Author : Letizia Gnetti
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06

Advances In Molecular Biology Knowledge Of Rectal Cancer And Forthcoming Role Of Liquid Biopsy written by Letizia Gnetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Medical categories.

The treatment algorithm of locally advanced rectal cancer has been changing in the last years and a multidisciplinary approach is required to select effective and personalized treatment. Nowadays, total neoadjuvant treatment is an established validated strategy for high-risk rectal cancer patients as it showed and has shown increased complete response rate representing a new standard of care. Therefore, the selection of predictive molecular markers is, even more, an essential and pursued medical needs goal. Moreover, regarding the early stage of disease, one major question pertains to the risk of recurrence and minimal residual disease: when is staging based on pathologic features adequate for a shared therapeutic decision? This is one of the main issues concerning future advances.

Rna Sequencing In Clinical Oncology For Metabolism And Immunity

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Author : Ye Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-01

Rna Sequencing In Clinical Oncology For Metabolism And Immunity written by Ye Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-01 with Medical categories.