Separations For Biotechnology 3
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Separations For Biotechnology 3
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Author : D. L. Pyle
language : en
Publisher:
Release Date : 1994
Separations For Biotechnology 3 written by D. L. Pyle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Science categories.
Bioseparation is a technique by which the products of fermentations or biotransformations are recovered for subsequent use. This volume explores the technical problems posed by bioprocessing, and the importance of the recovery of pure biological products for product safety and quality.
Centrifugal Separations In Biotechnology
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Author : Wallace Woon-Fong Leung
language : en
Publisher: Butterworth-Heinemann
Release Date : 2020-03-13
Centrifugal Separations In Biotechnology written by Wallace Woon-Fong Leung and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with Technology & Engineering categories.
Centrifugal Separations in Biotechnology, Second Edition, is the only book on the market devoted to centrifugal separation in biotechnology. Key topics covered include a full introduction to centrifugation, sedimentation and separation; detailed coverage of centrifuge types, including batch and semi-batch centrifuges, disk-stack and tubular decanter centrifuges; methods for increasing solids concentration; laboratory and pilot testing of centrifuges; selection and sizing centrifuges; scale-up of equipment, performance prediction and analysis of test results using numerical simulation. Centrifugal Separations in Biotechnology, Second Edition, provides guidance on troubleshooting and optimizing centrifuges, and then goes on to explore the commercial applications of centrifuges in biotechnology. It gives detailed process information and data to assist in the development of particular processes from existing systems. It is of value to professionals in the chemical, bioprocess, and biotech sectors, and all those concerned with bioseparation, bioprocessing, unit-operations and process engineering. - Provides a comprehensive guide to centrifuges, their optimal development, and their operation in the biotechnology industry - Updated throughout based on developments in industrial applications and advances in our understanding of centrifugal separations in biotechnology - Discusses applications for the separation of proteins, DNA, mitochondria, ribosomes, lysosomes and other cellular elements - Includes new sections on use of optimal polymer dosage in waste treatment, new centrifuge designs for applications in algae processing, biopharma, and more
Separations For Biotechnology 2
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Author : D. Leo Pyle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Separations For Biotechnology 2 written by D. Leo Pyle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The challenge of bioseparations is to isolate and purify identified products from the dilute product broth produced from cell culture. Innovation in bioseparations technology is increasingly driven by the requirements imposed by the growing importance of production on a process scale of injectable-grade products, and economic pressures to improve the efficiency of downstream processing. As in other areas of technical change, science does not necessarily precede new technology: progress results from a complex and messy mixture of advances in understanding, ingenious ideas, novel techniques and chance discoveries. What is certain is that close interaction between academics and practitioners, biological scientists and process engineers is needed to solve the problems of bioseparations. The Second International Conference on Separations for Biotechnology at Reading, UK, in September 1990 set out to provide a critical multidisciplinary forum for the discussion of bioseparations. This volume contains the papers presented at the meeting. The meeting was organised around six themes with oral and poster presentations on the science and practice of bioseparations technology, and the same structure has been kept for this book. We have also included the texts of the keynote review paper by Professor Alan Michaels and the introductory review papers specially commissioned for the conference. Within each part of this book the review paper is followed by the contributed papers grouped alphabetically by their first author. All the original papers published here were accepted for publication after scientific refereeing.
Separations For Biotechnology 3
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Author : D. L. Pyle
language : en
Publisher:
Release Date : 1994
Separations For Biotechnology 3 written by D. L. Pyle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Bioseparations Of Proteins
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Author : Ajit Sadana
language : en
Publisher: Elsevier
Release Date : 1997-11-27
Bioseparations Of Proteins written by Ajit Sadana and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-27 with Science categories.
This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation.Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess. It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable framework for workers in different areas interested in bioseparations.Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures.Key Features* Protein inactivation and other aspects of biological stability are critical to an effective bioseparation process; This book is a detailed and critical review of the available literature in an area that is essential to the effectiveness, validation, and economics of bioseparation processes for drugs and other biological products; Conveniently assembled under one cover, the survey of the literature and resulting perspective will greatly assist engineers and chemists in designingand improving their own processes; Key features of the text include:* detailed data on biological stability under various bioseparation conditions* extensive case studies from the literature on separation processes, validation, and economics* simplified analysis of protein refolding and inactivation mechanisms* consideration of adsorption theories and the effect of heterogeneity* coverage of both classical and novel bioseparation techniques, including chromatographic procedures
Separation Processes In The Food And Biotechnology Industries
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Author : A S Grandison
language : en
Publisher: Woodhead Publishing
Release Date : 1996-01-15
Separation Processes In The Food And Biotechnology Industries written by A S Grandison and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-15 with Medical categories.
This book reviews methods and techniques for separating food components and products of the biotechnology industry. The introduction focuses on food composition and some of the conventional separation techniques. Subsequent chapters deal with each specific type or area of application individually and include information on the basic principles, industrial equipment available, commercial applications and an overview of research and development.
Isolation And Purification Of Proteins
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Author : Rajni Hatti-Kaul
language : en
Publisher: CRC Press
Release Date : 2003-02-05
Isolation And Purification Of Proteins written by Rajni Hatti-Kaul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-05 with Medical categories.
This publication details the isolation of proteins from biological materials, techniques for solid-liquid separation, concentration, crystallization, chromatography, scale-up, process monitoring, product formulation, and regulatory and commercial considerations in protein production. The authors discuss the release of protein from a biological host, selectivity in affinity chromatography, precipitation of proteins (both non-specific and specific), extraction for rapid protein isolation, adsorption as an initial step for the capture of proteins, scale-up and commercial production of recombinant proteins, and process monitoring in downstream processing.
New Products And New Areas Of Bioprocess Engineering
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Author :
language : en
Publisher: Springer
Release Date : 2003-06-30
New Products And New Areas Of Bioprocess Engineering written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-30 with Science categories.
Today, ergot alkaloids have found widespread clinical use and more than 50 formulations contain natural or semisynthetic ergot alkaloids. They are used in the treatment of uterine atonia, postpartum bleeding, migraine, orthostatic circulatory disturbances, senile cerebral insufficiency, hypertension, hyp- prolactinemia, acromegaly, and Parkinsonism. Recently, new therapeutic - plications have emerged, e.g., against schizophrenia and for therapeutic usage based on newly discovered antibacterial and cytostatic effects, immunomodu- tory and hypolipemic activity. The broad physiological effects of ergot alkaloids are based mostly on their interactions with neurotransmitter receptors on the cells. The presence of "hidden structures'' resembling some important neu- humoral mediators (e.g., noradrenaline, serotonin, dopamine) in the molecules of ergot alkaloids could explain their interactions with these receptors [1]. Ergot alkaloids are produced by the filamentous fungi of the genus, Claviceps (e.g., Claviceps purpurea - Ergot, Mutterkorn). On the industrial scale these alkaloids were produced mostly by parasitic cultivation (field production of the ergot) till the end of the 1970s. Today this uneconomic method has been - placed by submerged fermentation. Even after a century of research on ergot alkaloids the search still continues for new, more potent and more selective ergot alkaloid derivatives
Highly Selective Separations In Biotechnology
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Author : G. Street
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Highly Selective Separations In Biotechnology written by G. Street and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Success in meeting the challenge to produce the commercial products anticipated by the exploitation of biological processes depends upon provid ing effective separation protocols. Effectiveness can be measured in terms of selectivity, purity, resolution and validatory success. The major processing problems are associated with either the selective recovery of molecules which are present in low concentrations from complex mixtures or the selective removal of contaminants from the desired molecule. Central to the evolution of processes satisfying this demand are the regulatory requirements being imposed by governments on the purity of a product, especially in the health care market. Synthetic organic chemists are increasingly finding it advantageous to conduct one or more steps using either enzymic biotransformations where molecules with a single and consistent stereochemistry or chirality are required. The underlying princi ples behind the methods, techniques and processes currently being used and developed commercially rely upon the biospecific nature and properties of the desired molecule. When these factors are married to the more traditional techniques of precipitation, chromatography, liquid-liquid extraction and membrane processes, powerful tools emerge, allowing highly selective separations to be designed. The logical extension of these combinations is to apply genetic engineering techniques to influence the separations at a more fundamental and structural level by modifying the target protein at source, during its synthesis, to facilitate its separation in a given, selective manner, leading to the distinct possibility of producing 'designer' separation programmes.
Separation And Purification Technology
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Author : Norman Li
language : en
Publisher: CRC Press
Release Date : 2013-12-16
Separation And Purification Technology written by Norman Li and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Science categories.
This book provides a sampler of developments in separation and purification technology, focusing on the application of membrane-based separations in biotechnology, commercial applications of emulsion liquid membranes, and economic evaluation of membrane technology.