Serm
DOWNLOAD
Download Serm PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Serm book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Selective Estrogen Receptor Modulators Serms
DOWNLOAD
Author : Marietta Anthony
language : en
Publisher:
Release Date : 2001
Selective Estrogen Receptor Modulators Serms written by Marietta Anthony and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Selective estrogen receptor modulators categories.
This volume examines basic and clinical findings on the role played by the oestrogen receptor (ER) and its modulation in multiple physiologic systems. The authors examine the potential of selective modification of ER actions for preventing chronic diseases and promoting healthy ageing. Research gaps and potential agendas for NIH research of ER action are identified, and related intervention strategies to extend the beneficial clinical outcomes are explored.
Serm Responsive Regulatory Elements Are Differentially Regulated By Tamoxifen And Raloxifene With Er Alpha And Er Beta
DOWNLOAD
Author : Lonnele J. Ball
language : en
Publisher:
Release Date : 2008
Serm Responsive Regulatory Elements Are Differentially Regulated By Tamoxifen And Raloxifene With Er Alpha And Er Beta written by Lonnele J. Ball and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Selective Estrogen Receptor Modulators
DOWNLOAD
Author : Antonio Cano
language : en
Publisher: Springer
Release Date : 2014-10-20
Selective Estrogen Receptor Modulators written by Antonio Cano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-20 with Medical categories.
The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Selective Estrogen Receptor Modulators
DOWNLOAD
Author : Andrea Manni
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-01-18
Selective Estrogen Receptor Modulators written by Andrea Manni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-18 with Medical categories.
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Selective Oestrogen Receptor Modulators Serms
DOWNLOAD
Author : Donato Agnusdei
language : en
Publisher: CRC Press
Release Date : 2000-03-07
Selective Oestrogen Receptor Modulators Serms written by Donato Agnusdei and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-07 with Medical categories.
Selective oestrogen receptor modulators (SERMs) are now recognised as a valuable method of maintaining the health of postmenopausal women. Aimed at the non-specialist, the book initially discusses the epidemiology of the menopause and the mechanism of action of oestrogen before concentrating specifically on the effect of SERMs, their safety profile and their role in clinical practice.
The Search For An Ideal Serm
DOWNLOAD
Author : Rachel G.C. Yahn
language : en
Publisher:
Release Date : 2014
The Search For An Ideal Serm written by Rachel G.C. Yahn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Estrogen Receptor And Breast Cancer
DOWNLOAD
Author : Xiaoting Zhang
language : en
Publisher: Springer
Release Date : 2018-10-16
Estrogen Receptor And Breast Cancer written by Xiaoting Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-16 with Medical categories.
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Characterization Of A Novel Serm Fc 1271a
DOWNLOAD
Author : Tracy Lynn Taras
language : en
Publisher:
Release Date : 2001
Characterization Of A Novel Serm Fc 1271a written by Tracy Lynn Taras and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Finding An Ideal Serm
DOWNLOAD
Author : Sophie G. Bender
language : en
Publisher:
Release Date : 2020
Finding An Ideal Serm written by Sophie G. Bender and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health Progress And Promise
DOWNLOAD
Author : V Craig Jordan
language : en
Publisher: World Scientific
Release Date : 2013-05-27
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health Progress And Promise written by V Craig Jordan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Science categories.
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.