Signaling Pathways Associated With Alzheimer S Disease And Possible Therapeutic Targets
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Signaling Pathways Associated With Alzheimer S Disease And Possible Therapeutic Targets
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Author : Jason Schapansky
language : en
Publisher:
Release Date : 2013
Signaling Pathways Associated With Alzheimer S Disease And Possible Therapeutic Targets written by Jason Schapansky and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Alzheimer S Disease Pathogenesis
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Author : Suzanne De La Monte
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12
Alzheimer S Disease Pathogenesis written by Suzanne De La Monte and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.
Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Redox Signaling In Neurodegenerative Diseases Biomarkers Targets And Therapies
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Author : Andreia Neves Carvalho
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-16
Redox Signaling In Neurodegenerative Diseases Biomarkers Targets And Therapies written by Andreia Neves Carvalho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-16 with Science categories.
Redox homeostasis results from the balance between the production of reactive species (e.g. ROS, RNS, etc) and their detoxification by endogenous or exogenous antioxidants. ROS play several important physiological roles, however, their excessive production or impaired detoxification is associated with oxidative stress and cellular injury. Importantly, oxidative damage to vulnerable central nervous system (CNS) cells is a common pathological feature of several neurodegenerative diseases. Antioxidants have been considered as attractive potential therapeutic agents to prevent or halt disease progression but the clinical efficacy of antioxidant treatment strategies is still marginal. Improvement of antioxidant therapy effectiveness might involve adjustment of preclinical to clinical settings and development of new efficient delivery methods and will require a more in-depth knowledge of cellular redox-signaling mechanisms. Promising novel redox-based therapeutic strategies are gaining relevance to combat oxidative stress associated with neurodegenerative diseases. These include boosting the endogenous antioxidant machinery through activation of the antioxidant master regulator Nrf2 (nuclear factor erythroid 2-related factor 2) or modulation of ROS production by NOX (nicotinamide adenine dinucleotide phosphate (NADPH) oxidase) inhibitors. Redox regulation of key cellular functions is currently recognized as an important cellular signaling mechanism and events such as post-translational modifications (e.g. S_glutathionylation, S_nitrosylation, glycosylation, etc) play important roles in redox signal transduction and might be instrumental to uncover pathological mechanisms and identify novel therapeutic targets in neurodegenerative diseases. This Research Topic focuses on redox signaling mechanisms and aims to provide novel insights into the role of redox-signaling, with particular emphasis on redox regulation involving post-translational modifications, in the pathophysiology of neurodegenerative diseases. Moreover, it aims to present an overview of the potential of antioxidants as therapeutics for CNS disorders with a special focus on emerging novel therapeutic redox-based strategies. We are particularly interested in studies: -addressing new redox-based molecular mechanisms contributing to neurodegenerative diseases; -exploring the role of naturally occurring compounds, standard medications, and nutraceuticals with antioxidant properties in modulating redox-signaling pathways and limiting and/or preventing oxidative damage associated with these disorders; -addressing mechanistically the role of post-translational modifications in the pathophysiology of neurodegenerative disorders.
Neurodegenerative Diseases
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Author : Philip Beart
language : en
Publisher: Springer
Release Date : 2017-07-03
Neurodegenerative Diseases written by Philip Beart and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-03 with Medical categories.
Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.
Exploring Molecular Targets To Treat Neurodegenerative Disorders
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Author : Prashant Tiwari
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2024-05-01
Exploring Molecular Targets To Treat Neurodegenerative Disorders written by Prashant Tiwari and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-01 with Medical categories.
This book delves into the delicate realm of neurodegenerative illnesses, navigating the vast landscape of molecular targets with care and purpose. Researchers are studying the complex pathways involved in diseases such as Alzheimer’s, Parkinson’s, and Huntington’s in order to identify specific molecules that could be targeted for therapy. The present work explores potential methods of intervention by carefully analysing neural circuits, protein misfolding, and genetic predispositions, unravelling the complexities of the human mind by focusing on individual molecular targets. As new findings emerge, reducing the severe consequences of neurodegenerative illnesses becomes increasingly possible, providing optimism for millions of people throughout the world.
Advances In Brain Disorders From Mechanisms To Therapeutic Targets
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Author : Arianna Bellucci
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-20
Advances In Brain Disorders From Mechanisms To Therapeutic Targets written by Arianna Bellucci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-20 with Science categories.
Signal Transduction Pathways Part D
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Author : Marc Diederich
language : en
Publisher: Wiley-Blackwell
Release Date : 2007-03-26
Signal Transduction Pathways Part D written by Marc Diederich and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-26 with Science categories.
Keynote speakers at the cell signaling meeting in Luxembourg have provided chapters on hypoxia signal transduction, phosphoserine/threonine-binding domains, targeting of polycomb repressive complexes, conserved signaling mechanisms in innate immunity, and signal transduction by stress-activated MAP kinases. Other topics included among these reports on recent research are receptor signaling, protein kinase cascades as therapeutic targets, cell death in cancer, inflammation-specific signaling, cell signaling pathways leading to regulated chromatin modifications, and transcriptional control. The chapters have been published in four volumes (Part A to D), offering a comprehensive overview about this exciting topic. This fourth volume focuses on inflammatory signaling pathways and the role of signaling pathways in neuropathological conditions including depression, schizophrenia, Alzheimer's disease, and other senile dementias. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Immunoreceptor Signaling
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Author : L. E. Samelson
language : en
Publisher: Cold Spring Harbor Perspective
Release Date : 2011
Immunoreceptor Signaling written by L. E. Samelson and has been published by Cold Spring Harbor Perspective this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structures of the T-cell and B-cell immunoreceptors, the numerous kinases and adaptors that associate with their intracellular tails, and the downstream signaling pathways that lead to transcription of interleukins and other outputs. Other contributions examine the roles of other receptors, co-stimulatory signals, and innate immune responses in regulation of immunoreceptor signaling. The spatial organization of the immunological synapses connecting lymphocytes and antigen-presenting cells is also discussed, along with the role of the cytoskeleton in immunoreceptor function. Computational models of the signaling processes complete the volume, making it essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.
Molecular Mechanisms Of Neurodegenerative Diseases
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Author : Marie-Francoise Chesselet
language : en
Publisher:
Release Date : 2014-01-15
Molecular Mechanisms Of Neurodegenerative Diseases written by Marie-Francoise Chesselet and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Neuroprotection
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Author : Matilde Otero-Losada
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-11-26
Neuroprotection written by Matilde Otero-Losada and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.