Signalling Pathways In Acute Oxygen Sensing
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Signalling Pathways In Acute Oxygen Sensing
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-30
Signalling Pathways In Acute Oxygen Sensing written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Science categories.
Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechanisms. Some favour the view that the primary signalling event is a reduction in cell redox state and reactive oxygen species (ROS) due to general inhibition of the electron transport chain (ETC); others support a key role for complex III of the ETC and an increase in ROS generation, while others doubt either of these components is the key intermediary. All these hypotheses are discussed in the book, together with conceptual problems concerning the ability of mitochondria to respond to physiological hypoxia. The other area of controversy covered in the book is the identity of the endpoint effector(s). Some authors favour K+ channel inhibition, followed by depolarization and Ca2+ entry via L-type channels, while others propose that release of Ca2+ from intracellular stores, or capacitative Ca2+ entry and other voltage-independent pathways may be more important. The book also describes evidence for an endothelium-dependent Ca2+-sensitizing pathway involving Rho and possibly other kinases. While some of these differences can be attributed to variation between tissues, many must be related to differences in interpretation or methodology. In this book, experts in the field of acute oxygen sensing working in different tissues address these controversies and their possible origins, and discuss possible approaches whereby these controversies might be resolved. The book will be of great interest to all those working in fields where oxygen sensing is important, particularly cancer and wound healing, as well as researchers in drug discovery and biotechnology.
Morphofunctional And Neurochemical Aspects Of The Mammalian Carotid Body
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Author : Nikolai E. Lazarov
language : en
Publisher: Springer Nature
Release Date : 2023-11-09
Morphofunctional And Neurochemical Aspects Of The Mammalian Carotid Body written by Nikolai E. Lazarov and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-09 with Science categories.
This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis. The authors review the state of the art of the neurochemical anatomy of carotid body ́s cell populations with a special reference to their structural and neurochemical plasticity. The essential role of this organ in the generation, progression and maintenance of cardiorespiratory and metabolic diseases in humans and other mammals is presented. Finally, the book summarizes current knowledge on the stem cell niche in the mammalian carotid body and discusses its contribution to replacement cell therapy and other potential applications in translational research. This book represents an essential reading for physiologists, anatomists, cell, and developmental biologists, as well as physicians, veterinarians, and biomedical researchers.
The Arterial Chemoreceptors
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Author : Yoshiaki Hayashida
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
The Arterial Chemoreceptors written by Yoshiaki Hayashida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.
Gas Sensing In Cells
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Author : Shigetoshi Aono
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-10-31
Gas Sensing In Cells written by Shigetoshi Aono and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with Science categories.
Gas molecules such as O2, NO, CO and ethylene are present in the environment and are endogenously (enzymatically) produced to act as signalling molecules in biological systems, including the regulation of metabolic networks, chemotaxis, circadian rhythms, mammalian hypoxia responses, and plant ethylene responses by transcriptional, translational, or post translational control. Sensing these gas molecules is the first step in their acting as signalling molecules. When a sensor domain/protein senses an external signal, intra- and inter-molecular signal transductions take place to regulate the biological function of a regulatory domain/protein such as DNA-binding, enzymatic activity, or protein–protein interaction. Interaction between gas molecules and sensor proteins is essential for recognition of gas molecules. Metal-containing prosthetic groups such as haem, iron–sulfur clusters, and non-haem iron centres are widely used. As these metal-containing centres are good spectroscopic probes, detail characterizations have utilized spectroscopic techniques along with X-ray crystallography. Covering both the signalling and sensing of gaseous molecules, this book provides the first comprehensive overview of gas sensor proteins in both prokaryotic and eukaryotic cells. This book will be particularly interesting to postgraduates and researchers in biochemistry, molecular biology and metallobiology.
Vascular Development
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-20
Vascular Development written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-20 with Science categories.
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Arterial Chemoreceptors In Physiology And Pathophysiology
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Author : Chris Peers
language : en
Publisher: Springer
Release Date : 2015-08-24
Arterial Chemoreceptors In Physiology And Pathophysiology written by Chris Peers and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-24 with Medical categories.
Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
Handbook Of Neurochemistry And Molecular Neurobiology
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Author : Dianna A. Johnson
language : en
Publisher: Springer Nature
Release Date : 2010-07-29
Handbook Of Neurochemistry And Molecular Neurobiology written by Dianna A. Johnson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-29 with Medical categories.
The Second Edition of the Handbook of Neurochemistry, which was published about 24 years ago, consisted of 10 volumes. The present, Third Edition, The Handbook of Neurochemistry and Molecular Biology, is over twice as large; indicating a great expansion of neuroscience in the past two decades. We now have not only more data on brain mechanisms relating to behavior (mental activity and cognitive processes), but we understand in some detail the mechanisms of these functions. The past editions focused purely on neurochemical aspects the new edition reflects the need of interdisciplinary approach for understanding neural mechanisms. In addition to metabolic processes, the 17 new volumes explore the functions of peptides, transport, immunology and other processes not well understood 24 years ago. Several volumes deal with pathological changes and with repair and therapy of both mental and neurological pathologies. The purpose of this edition is to provide an evaluation of the results of investigations; to serve as a guide rather than enumerating all the available findings in detail it indicates future possibilities and the existing knowledge in neuroscience. The significance of understanding neural processes needs no emphasis its potential is primary in mental and neural pathology, but also in physiological importance. The volumes should serve as an aid to researchers expanding our knowledge and to educators training the next generation of neuroscientists and clinicians.
Hypoxia And Cardiorespiratory Control
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Author : Yasumasa Okada
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-09
Hypoxia And Cardiorespiratory Control written by Yasumasa Okada and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-09 with Science categories.
The Journal Of Experimental Biology
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Author :
language : en
Publisher:
Release Date : 2008
The Journal Of Experimental Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Biology categories.
Biochemical Adaptation
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Author : Peter W. Hochachka
language : en
Publisher: Oxford University Press
Release Date : 2002-01-17
Biochemical Adaptation written by Peter W. Hochachka and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-17 with Science categories.
The study of biochemical adaption provides fascinating insights into how organisms "work" and how they evolve to sustain physiological function under a vast array of environmental conditions. This book describes how the abilities of organisms to thrive in widely different environments derive from two fundamental classes of biochemical adaptions: modifications of core biochemical processes that allow a common set of physiological functions to be conserved, and "inventions" of new biochemical traits that allow entry into novel habitats. Biochemical Adaptation: Mechanisms and Process in Physiological Evolution asks two primary questions. First, how have the core biochemical systems found in all species been adaptively modified to allow the same fundamental types of physiological processes to be sustained throughout the wide range of habitat conditions found in the biosphere? Second, through what types of genetic and biochemical processes have new physiological functions been fabricated? The primary audience for this book is faculty, senior undergraduates, and graduate students in environmental biology, comparative physiology, and marine biology. Other likely readers include workers in governmental laboratories concerned with environmental issues, medical students interested in some elements of the book, and medical researchers.