Single Cell Molecular Characterization For Improving Cancer Immunotherapy
DOWNLOAD
Download Single Cell Molecular Characterization For Improving Cancer Immunotherapy PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Single Cell Molecular Characterization For Improving Cancer Immunotherapy book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Single Cell Molecular Characterization For Improving Cancer Immunotherapy
DOWNLOAD
Author : Qihui Shi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-22
Single Cell Molecular Characterization For Improving Cancer Immunotherapy written by Qihui Shi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-22 with Medical categories.
Topic Editor Qihui Shi is the scientific co-founder of JunHealth, a company aiming to developing single-cell sequencing technologies for clinical applications, and received research funding from BeiGene.
Application Of Systems Biology In Molecular Characterization And Diagnosis Of Cancer
DOWNLOAD
Author : Cheng Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-27
Application Of Systems Biology In Molecular Characterization And Diagnosis Of Cancer written by Cheng Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-27 with Science categories.
Revolutionizing Immunological Disease Understanding Through Single Cell Multi Omics Technologies
DOWNLOAD
Author : Jennie R. Lill
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-17
Revolutionizing Immunological Disease Understanding Through Single Cell Multi Omics Technologies written by Jennie R. Lill and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-17 with Medical categories.
Single cell technologies, encompassing genomics and proteomics, are at the forefront of revolutionizing our understanding of biological mechanisms at the cellular level, particularly in the context of immunological diseases. These technologies have enabled researchers to dissect complex cellular processes with unprecedented detail, providing crucial spatial context that was previously unattainable. Recent advancements have led to the formulation of new signaling hypotheses and opened novel pathways for therapeutic interventions. The integration of multi-omics approaches, which combine various single cell technologies, has further enhanced our ability to explore intracellular signaling and disease pathology. Despite these advancements, challenges remain in optimizing data interpretation and understanding the full scope of these technologies' impact on immunological and cancer immunological disease pathogenesis. There is a pressing need for continued exploration and refinement of these methodologies to fully harness their potential in elucidating disease mechanisms.
Immunotherapy And Multimodality Therapy For Lung Cancer
DOWNLOAD
Author : Qun Xue
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-07
Immunotherapy And Multimodality Therapy For Lung Cancer written by Qun Xue and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-07 with Medical categories.
Circulating Tumor Cells
DOWNLOAD
Author : Richard J. Cote
language : en
Publisher: Springer Nature
Release Date : 2023-08-01
Circulating Tumor Cells written by Richard J. Cote and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-01 with Medical categories.
It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes). CTC play a central role in tumor dissemination and metastasis, and have been established as an important evaluative and research tool in advanced cancer, and potentially important in early stage disease. CTC defines tumor cells circulating in blood, while Disseminated Tumor Cells (DTC) refers to tumor cells identified in bone marrow. CTC/DTC are extremely rare events, even in late stage cancer, and their detection has presented enormous technical challenges, with the emergence of multiple technologies developed to address these challenges, including enrichment, identification and sophisticated analytical techniques to evaluate CTC and other cells in circulation that may also be important in the biology of metastasis. As foundational as CTC/DTC has been, the field of liquid biopsy has expanded well beyond these analytes. The relevance of circulating nucleic acids derived from tumor cells has quickly progressed from research to the clinic. There are now well established clinical applications for using ctDNA/RNA to determine therapeutic targets, follow disease progression and detect cancer recurrence long before routine clinical methods. One of the most exciting new areas of work is the possibility of using these circulating tumor derived nucleic acids to detect cancer at its earliest and potentially most curable stages. Another new and burgeoning area is the detection and analysis of ctExosomes. These highly abundant particles which are actively secreted from tumor (and indeed all) cells represent a novel way to detect and define multiple analytes of importance, including proteins, DNA and meDNA, RNA, miRNA, and other cell components that are protected and preserved in these compact structures. This second edition of Circulating Tumor Cells: Advances in Liquid Biopsy Technologies is entirely new and brings together leaders and innovators in the field of liquid biopsy, including basic and molecular biologists, chemists, engineers, statisticians, experts in tumor banking, test developers, research administrators and clinicians. A special feature of this book is that it includes chapters from the members of the US National Cancer Institute Liquid Biopsy Consortium. This edition also includes many of the participants of the latest international meeting on the Advances in Circulating Tumor Cells (ACTC) which is held in Greece every two years and gathers the most important liquid biopsy investigators from around the world. Thus, this edition represents the most comprehensive and up-to-date resource for those who want to further explore the exciting field of CTC and other liquid biopsy technologies. The new edition will be useful to a wide audience including scientists studying metastasis, cancer researchers, translational scientists, oncologic surgeons, medical oncologists, members of the biopharmaceutical industry, and graduate and undergraduate students studying cancer biology.
The Elusive Road Towards Effective Cancer Prevention And Treatment
DOWNLOAD
Author : Franklyn De Silva
language : en
Publisher: CRC Press
Release Date : 2022-10-28
The Elusive Road Towards Effective Cancer Prevention And Treatment written by Franklyn De Silva and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-28 with Medical categories.
Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients’ quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.
Circulating Tumor Cells In Breast Cancer Metastatic Disease
DOWNLOAD
Author : Roberto Piñeiro
language : en
Publisher: Springer Nature
Release Date : 2020-04-17
Circulating Tumor Cells In Breast Cancer Metastatic Disease written by Roberto Piñeiro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Medical categories.
This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.
Novel Immune Markers And Predictive Models For Immunotherapy And Prognosis In Breast And Gynecological Cancers
DOWNLOAD
Author : Chao Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-05
Novel Immune Markers And Predictive Models For Immunotherapy And Prognosis In Breast And Gynecological Cancers written by Chao Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-05 with Medical categories.
Precision medicine is an emerging practice by which clinicians aim to deliver a personalized treatment program to affected patients based on information gained from their individual clinical and biological profiles. In the context of precise cancer immunotherapy, multi-omics, high-throughput sequencing, big data, and other approaches serve to screen new predictive factors for immunotherapy response and prognosis in cancer patients.
Lung Cancer
DOWNLOAD
Author : Henry S. Park
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-06-02
Lung Cancer written by Henry S. Park and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Medical categories.
Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.
Textbook Of Personalized Medicine
DOWNLOAD
Author : Kewal K. Jain
language : en
Publisher: Springer Nature
Release Date : 2020-12-05
Textbook Of Personalized Medicine written by Kewal K. Jain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-05 with Medical categories.
This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.