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Small Gtpases In Disease


Small Gtpases In Disease
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Small Gtpases In Disease B


Small Gtpases In Disease B
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Author : William E. Balch
language : en
Publisher: Academic Press
Release Date : 2008

Small Gtpases In Disease B written by William E. Balch and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.




Small Gtpases In Disease


Small Gtpases In Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-04-01

Small Gtpases In Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-01 with Science categories.


The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volume 1 onward.



Small Gtpases In Disease Part A


Small Gtpases In Disease Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-09-02

Small Gtpases In Disease Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Science categories.


The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/ This volume is the first of two planned volumes on the topic of small GTPases and their role in disease.



Small Gtpases In Disease


Small Gtpases In Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-04-15

Small Gtpases In Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Science categories.


The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect - full-text online of volume 1 onward.



Rho Gtpases Molecular Biology In Health And Disease


Rho Gtpases Molecular Biology In Health And Disease
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Author : Fort Philippe
language : en
Publisher: World Scientific
Release Date : 2017-12-12

Rho Gtpases Molecular Biology In Health And Disease written by Fort Philippe and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-12 with Science categories.


Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology. Contents: An Historical and Evolutionary PerspectiveAtypical Rho GTPases in Health and DiseaseRegulators of Rho SignalingRho GTPases in Cadherin-Based Cell-Cell InteractionsRho Signaling in MechanotransductionPost-Translational modifications of Rho GTPasesRhoA Mutations in Cancer: Oncogenes or Tumor-SuppressorsModulation of Osteoclast Differentiation and Function by Rho GTPasesRhoGEFs as Therapeutic TargetsEndothelial-Specific Rho GTPase Signaling During Leukocyte Extravasation Readership: Molecular and cell biologists, post-graduate and medical students interested in cell biology. Keywords: Rho GTPases;Signaling Oathways;F-actin;Cytoskeleton;Adhesion;Migration;CancerReview: Key Features: Different integration levels for a better understanding of biological and pathological implications of Rho signalingChapters cover updated and original Rho-controlled aspects of cell biologyContributors are leaders in their fields of research



Small Gtpases In Disease


Small Gtpases In Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-05-09

Small Gtpases In Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-09 with Science categories.


The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect - full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/ This volume is the first of two planned volumes on the topic of small GTPases and their role in disease.



Ras Superfamily Small G Proteins Biology And Mechanisms 1


Ras Superfamily Small G Proteins Biology And Mechanisms 1
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Author : Alfred Wittinghofer
language : en
Publisher: Springer
Release Date : 2014-09-22

Ras Superfamily Small G Proteins Biology And Mechanisms 1 written by Alfred Wittinghofer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Science categories.


This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.



Gtpase Protocols


Gtpase Protocols
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Author : Ed Manser
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03

Gtpase Protocols written by Ed Manser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.


In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on which the methods are based. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.



Ras Family Gtpases


Ras Family Gtpases
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Author : Channing Der
language : en
Publisher: Springer
Release Date : 2006-09-13

Ras Family Gtpases written by Channing Der and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-13 with Medical categories.


Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.



Rab Gtpases And Membrane Trafficking


Rab Gtpases And Membrane Trafficking
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Author : Guangpu Li
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-05-21

Rab Gtpases And Membrane Trafficking written by Guangpu Li and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-21 with Science categories.


"Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that"