Special Issue On Ionic Channels Ii
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Special Issue On Ionic Channels Ii
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Author : M. P. Blaustein
language : en
Publisher: Springer
Release Date : 2013-12-01
Special Issue On Ionic Channels Ii written by M. P. Blaustein and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Science categories.
Handbook Of Plant And Animal Toxins In Food
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Author : Gulzar Ahmad Nayik
language : en
Publisher: CRC Press
Release Date : 2022-04-18
Handbook Of Plant And Animal Toxins In Food written by Gulzar Ahmad Nayik and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Technology & Engineering categories.
The prevalence of naturally occurring toxins in plant and animal foods represents one of the most significant food safety issues, drawing the attention of both scientists and regulators alike. This unexplored area related to food quality is indeed a big concern for consumers, various regulatory authorities, and food industries. Apart from essential nutrients, several food crops are capable of producing a vast array of nonnutritious secondary metabolic products. These toxins produced as secondary metabolites have the potential to exhibit both beneficial and deleterious effects in both human beings and animals. Nevertheless, there has been huge progress in agricultural practices and food processing technologies, but still the number of nonnutritive substances and naturally derived toxins persist in our diet. Handbook of Plant and Animal Toxins in Food: Occurrence, Toxicity, and Prevention, focuses on various selected toxins in foods derived from plants as well as animals. The prominent plant toxins include solanine and chaconine, mushroom toxins, phytates, tannins, oxalates, goitrogens, gossypol, phytohemagglutinins, erucic acid, saponins, cyanogenic glycosides, enzyme inhibitors, BOAA (lathyrogens), toxic amino acids and toxic fatty acids. The prominent animal toxins covered in the book include various seafood toxins, shellfish toxins and biogenic amines. Key Features: Presents complete information about a plethora of toxins Provides quick and easy access to data on major plant and animal toxins Covers distribution of toxins in the plant and animal kingdom Provides comprehensive information on chemistry, safety and precautions of each toxin Commencing with a brief introduction of food toxins, this book is designed in such a way that the readers will be introduced to toxicity, safety and occurrence of each toxin selected. It also discusses the in-depth detailed information on food poisoning and its prevention. The book will also shed light on foodborne illness associated with toxins. The primary audience for this work will be food scientists, food toxicologists, university scholars and college students. Furthermore, the book will be of immense help for public health officials, pharmacologists, and food safety officers who are involved with enforcing regulations meant to ensure the safety of a particular food
Dynamics Of Engineered Artificial Membranes And Biosensors
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Author : William Hoiles
language : en
Publisher: Cambridge University Press
Release Date : 2018-05-03
Dynamics Of Engineered Artificial Membranes And Biosensors written by William Hoiles and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-03 with Business & Economics categories.
A state-of-the-art guide to building synthetic membranes for biological devices, covering their construction, measurement, and modelling.
Expression And Analysis Of Recombinant Ion Channels
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Author : Jeffrey J. Clare
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-21
Expression And Analysis Of Recombinant Ion Channels written by Jeffrey J. Clare and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-21 with Science categories.
Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. These latest developments are covered here for the first time, contributed by editors and authors working for major pharmaceutical companies and who routinely apply these techniques in their daily work. The first three chapters cover the use of the Xenopus oocyte expression system for structure-function studies, from basic approaches for manipulating ion channel cDNAs to more specialized but powerful techniques. This is followed by reviews of strategies and methodologies available for expressing channels in mammalian cells and for their analysis by patch-clamp electrophysiology. Chapters 6 to 8 review the latest methodologies for ion channel drug discovery, including high throughput screening using fluorescence and luminescence, as well as automated planar array electrophysiology. The remaining two chapters focus on approaches for determining ion channel crystal structures and on computational approaches to understanding channel mechanisms at atomic resolution. Rather than provide detailed protocols, indicated by references in each chapter, the authors provide a comprehensive and easily accessible overview of the techniques involved, reviewing underlying principles and providing working guidelines as well as an understanding of the key theoretical and practical considerations associated with each topic. In each case, this practical advice is illustrated by real life examples, taken either from the author's own experience or from key examples in the literature, providing valuable practical hints not found elsewhere. The result is a compendium of practical ion channel information that will prove a valuable resource to academic and industrial workers alike.
Pharmacology Of Mitochondria
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Author : Harpreet Singh
language : en
Publisher: Springer
Release Date : 2017-08-11
Pharmacology Of Mitochondria written by Harpreet Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with Medical categories.
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.
Trafficking Of Cardiac Ion Channels
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Author : Marcel Verges
language : en
Publisher: MDPI
Release Date : 2021-04-27
Trafficking Of Cardiac Ion Channels written by Marcel Verges and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-27 with Science categories.
Protein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesion molecules, and adaptors. These influence protein targeting, anchoring, and retention in specific surface domains along the cardiomyocyte sarcolemma, such as intercalated discs, T-tubules, or the lateral membrane. Alterations in ion channel trafficking are the cause of channelopathies associated with inherited arrhythmias leading to sudden death. An outstanding question is how these molecular alterations lead to disease. In this volume, scientists share their vision to understand how cardiac ion channel trafficking is regulated and how it may become altered, leading to channelopathies that often turn into deadly arrhythmias. Data generated can be translated to a clinical context, hopefully turning into approaches to help prevention and treatment, which is of utmost importance, both medically and socially.
Ion Channels Of Nociception
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Author : Rashid Giniatullin
language : en
Publisher: MDPI
Release Date : 2020-12-02
Ion Channels Of Nociception written by Rashid Giniatullin and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
The Special Issue “Ion Channels of Nociception” contains 13 articles united by a focus on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes; nociceptive roles of P2X3, ASIC, Piezo and TRP channels; pain control through GPCRs and pharmacological agents; and nonpharmacological treatment with electroacupuncture.
Textbook Of Ion Channels Volume Ii
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Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2023-06-28
Textbook Of Ion Channels Volume Ii written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-28 with Science categories.
The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume II starts with ion channel taxonomy and features coverage of major ion channel families, and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology, and roles in dis- ease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium- activated potassium channels, cyclic nucleotide-gated channels, pacemaker ion channels, chloride channels, ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors, and proton channels. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; offer a modern guide to the properties of major ion channel families; and include coverage of key examples of regulatory, physiological and disease roles for ion channels.
Current Topics In Membranes
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Author :
language : en
Publisher: Academic Press
Release Date : 1992-01-08
Current Topics In Membranes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-08 with Science categories.
Current Topics in Membranes
Mechanisms Of Ion Channels Voltage Dependency
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Author : Gildas Loussouarn
language : en
Publisher: Frontiers E-books
Release Date :
Mechanisms Of Ion Channels Voltage Dependency written by Gildas Loussouarn and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.