Statistical Genomics
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Handbook Of Statistical Genomics
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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-09-10
Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-10 with Science categories.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Methods In Statistical Genomics
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Author : Philip Chester Cooley
language : en
Publisher: RTI Press
Release Date : 2016-08-29
Methods In Statistical Genomics written by Philip Chester Cooley and has been published by RTI Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-29 with Medical categories.
The objective of this book is to describe procedures for analyzing genome-wide association studies (GWAS). Some of the material is unpublished and contains commentary and unpublished research; other chapters (Chapters 4 through 7) have been published in other journals. Each previously published chapter investigates a different genomics model, but all focus on identifying the strengths and limitations of various statistical procedures that have been applied to different GWAS scenarios.
Statistical Genomics
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Author : Ewy Mathé
language : en
Publisher:
Release Date : 2016
Statistical Genomics written by Ewy Mathé and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Biomedicine categories.
Principles Of Statistical Genomics
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Author : Shizhong Xu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-10
Principles Of Statistical Genomics written by Shizhong Xu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-10 with Science categories.
Statistical genomics is a rapidly developing field, with more and more people involved in this area. However, a lack of synthetic reference books and textbooks in statistical genomics has become a major hurdle on the development of the field. Although many books have been published recently in bioinformatics, most of them emphasize DNA sequence analysis under a deterministic approach. Principles of Statistical Genomics synthesizes the state-of-the-art statistical methodologies (stochastic approaches) applied to genome study. It facilitates understanding of the statistical models and methods behind the major bioinformatics software packages, which will help researchers choose the optimal algorithm to analyze their data and better interpret the results of their analyses. Understanding existing statistical models and algorithms assists researchers to develop improved statistical methods to extract maximum information from their data. Resourceful and easy to use, Principles of Statistical Genomics is a comprehensive reference for researchers and graduate students studying statistical genomics.
Statistical Genomics
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Author : Ben Hui Liu
language : en
Publisher: CRC Press
Release Date : 2017-11-22
Statistical Genomics written by Ben Hui Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Mathematics categories.
Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.
Statistical Genomics
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Author : Brooke Fridley
language : en
Publisher: Springer Nature
Release Date : 2023-03-16
Statistical Genomics written by Brooke Fridley and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Science categories.
This volume provides a collection of protocols from researchers in the statistical genomics field. Chapters focus on integrating genomics with other “omics” data, such as transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Statistical Genomics hopes that by covering these diverse and timely topics researchers are provided insights into future directions and priorities of pan-omics and the precision medicine era.
Computational And Statistical Approaches To Genomics
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Author : Wei Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
Computational And Statistical Approaches To Genomics written by Wei Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Science categories.
Computational and Statistical Genomics aims to help researchers deal with current genomic challenges. Topics covered include: overviews of the role of supercomputers in genomics research, the existing challenges and directions in image processing for microarray technology, and web-based tools for microarray data analysis; approaches to the global modeling and analysis of gene regulatory networks and transcriptional control, using methods, theories, and tools from signal processing, machine learning, information theory, and control theory; state-of-the-art tools in Boolean function theory, time-frequency analysis, pattern recognition, and unsupervised learning, applied to cancer classification, identification of biologically active sites, and visualization of gene expression data; crucial issues associated with statistical analysis of microarray data, statistics and stochastic analysis of gene expression levels in a single cell, statistically sound design of microarray studies and experiments; and biological and medical implications of genomics research.
The Fundamentals Of Modern Statistical Genetics
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Author : Nan M. Laird
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-13
The Fundamentals Of Modern Statistical Genetics written by Nan M. Laird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-13 with Medical categories.
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Statistical Genetics
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Author : Benjamin Neale
language : en
Publisher: Garland Science
Release Date : 2007-11-30
Statistical Genetics written by Benjamin Neale and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-30 with Science categories.
Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.
An Introduction To Statistical Genetic Data Analysis
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Author : Melinda C. Mills
language : en
Publisher: MIT Press
Release Date : 2020-02-18
An Introduction To Statistical Genetic Data Analysis written by Melinda C. Mills and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-18 with Science categories.
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.