Stem Cells And Signaling Pathways

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Cancer Stem Cells And Signaling Pathways

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Author : Surajit Pathak
language : en
Publisher: Elsevier
Release Date : 2023-11-01

Cancer Stem Cells And Signaling Pathways written by Surajit Pathak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Stem Cells And Signaling Pathways

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Author : Surajit Pathak
language : en
Publisher: Elsevier
Release Date : 2023-09-28

Stem Cells And Signaling Pathways written by Surajit Pathak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-28 with Science categories.

Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19. Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue. - Provides a compilation of chapters dedicated to the study of the field with respect to properties of stem cells and their signaling pathways. It also provides detailed information on signaling pathways associated with stem cells - Provides a detailed and updated view of stem cell biology - Covers a wide range of areas within basic and translational research appropriate for scientists and clinicians engaged in studying the treatments for diseases from interdisciplinary perspectives - Highlights the use of different models for stem cell research, significance of stem cell signaling in drug discovery

An Introduction To Molecular Medicine And Gene Therapy

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Author : Thomas F. Kresina
language : en
Publisher: John Wiley & Sons
Release Date : 2004-03-24

An Introduction To Molecular Medicine And Gene Therapy written by Thomas F. Kresina and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-24 with Science categories.

An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: * Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations * Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases * Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter * Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.

Cell Signaling Pathways And Their Therapeutic Implication In Cancers

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Author : Muneeb U. Rehman
language : en
Publisher: Springer Nature
Release Date : 2025-03-28

Cell Signaling Pathways And Their Therapeutic Implication In Cancers written by Muneeb U. Rehman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-28 with Medical categories.

This book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer. ​

The Cell Biology Of Stem Cells

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Author : Eran Meshorer
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-11

The Cell Biology Of Stem Cells written by Eran Meshorer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-11 with Science categories.

Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model for the study of basic biological questions such as cell division, replication, transcription, cell fate decisions, and more. With embryonic stem (ES) cells that can generate each cell type in the mammalian body and adult stem cells that are able to give rise to the cells within a given lineage, basic questions at different developmental stages can be addressed. Importantly, both adult and embryonic stem cells provide an excellent tool for cell therapy, making stem cell research ever more pertinent to regenerative medicine. As the title The Cell Biology of Stem Cells suggests, our book deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. In the first chapter, “Early embryonic cell fate decisions in the mouse”, Amy Ralson and Yojiro Yamanaka describe the mechanisms that support early developmental decisions in the mouse pre-implantation embryo and the current understanding of the source of the most immature stem cell types, which includes ES cells, trophoblast stem (TS) cells and extraembryonic endoderm stem (XEN) cells.

Trends In Cell Signaling Pathways In Neuronal Fate Decision

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Author : Sabine Wislet
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-03-27

Trends In Cell Signaling Pathways In Neuronal Fate Decision written by Sabine Wislet and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-27 with Medical categories.

During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.

Molecular Biology Of The Cell

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Author :
language : en
Publisher:
Release Date : 2004

Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.

Cell Signaling

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Author : Adeeb Shehzad
language : en
Publisher: CRC Press
Release Date : 2025-04-17

Cell Signaling written by Adeeb Shehzad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-17 with Science categories.

This book provides a comprehensive understanding of cell signaling, molecular interactions, and their implications for human health and diseases. It introduces fundamental principles underlying cell communication through signaling molecules and their diverse transmission and reception mechanisms, highlighting their role in intercellular communication through voltage- and ion-gated channels, immunological and neuron synapses, and rhinovirus–receptor interaction involved in pathogenesis and disease development. Toward the end, the book highlights the profound implications of altered cell signaling pathways in the inflammation and immune response followed by the progression of various disorders, including cancer, endocrine disorders, and neurological illnesses. It explores the diagnostic and therapeutic implications of cell signaling in targeted therapies, highlighting advanced techniques for detecting signaling molecules and innovative therapeutic approaches to inspire new developments in precision medicine. It serves as an important resource for academics, students, and professionals in the fields of cell biology and biomedical sciences. Key Features: Provides in-depth understanding of cell signaling, exploring its complexities and impact on human health and disease Introduces fundamental principles of cell communication, emphasizing the different signaling molecules and their various transmission pathways Focuses on complex structures and functions of receptors, highlighting their essential role in intercellular communication and regulating cellular behavior Examines the molecular aspects of cell surface adhesion receptors, elucidating protein–protein interactions, signaling cascades, and enzyme–substrate interactions Discusses the impact of cell signaling on inflammation, cancer, and endocrine and neurological disorders

Targeting The Wnt Catenin Signaling Pathway In Cancer

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Author : Simone Patergnani
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-01

Targeting The Wnt Catenin Signaling Pathway In Cancer written by Simone Patergnani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-01 with Medical categories.

Cell Signaling Pathways In Development

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Author :
language : en
Publisher: Academic Press
Release Date : 2022-05-20

Cell Signaling Pathways In Development written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Science categories.

Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Includes the latest information on Cell Signaling Pathways in Development