Streptomyces In Nature And Medicine


Streptomyces In Nature And Medicine
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Streptomyces In Nature And Medicine


Streptomyces In Nature And Medicine
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Author : D. A. Hopwood
language : en
Publisher: Oxford University Press
Release Date : 2007-02-03

Streptomyces In Nature And Medicine written by D. A. Hopwood and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-03 with Medical categories.


This book highlights the lives of a group of soil microbes that make most of the antibiotics used in medicine today. Written by an insider, it describes how genetics tells us how these microscopic chemists compete in the soil and how their genes can be rearranged to make new antibiotics to fight re-emerging diseases.



Streptomyces In Nature And Medicine


Streptomyces In Nature And Medicine
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Author : David A. Hopwood
language : en
Publisher: Oxford University Press
Release Date : 2007-02-03

Streptomyces In Nature And Medicine written by David A. Hopwood and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-03 with Medical categories.


This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.



Streptomycin


Streptomycin
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Author : Selman Abraham Waksman
language : en
Publisher:
Release Date : 1949

Streptomycin written by Selman Abraham Waksman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1949 with Medical categories.




Actinobacteria


Actinobacteria
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Author : Dharumadurai Dhanasekaran
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-02-11

Actinobacteria written by Dharumadurai Dhanasekaran and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-11 with Science categories.


This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.



Basic Biology And Applications Of Actinobacteria


Basic Biology And Applications Of Actinobacteria
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Author : Shymaa Enany
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-12-05

Basic Biology And Applications Of Actinobacteria written by Shymaa Enany and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-05 with Science categories.


Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.



Assessment Of Long Term Health Effects Of Antimalarial Drugs When Used For Prophylaxis


Assessment Of Long Term Health Effects Of Antimalarial Drugs When Used For Prophylaxis
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-04-24

Assessment Of Long Term Health Effects Of Antimalarial Drugs When Used For Prophylaxis written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Medical categories.


Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.



Oxford Handbook Of Infectious Diseases And Microbiology


Oxford Handbook Of Infectious Diseases And Microbiology
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Author : Estée Török
language : en
Publisher: Oxford University Press
Release Date : 2017

Oxford Handbook Of Infectious Diseases And Microbiology written by Estée Török and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Anti-infective agents categories.


This handbook takes an integrated approach to both infectious disease and microbiology. Referenced to national frameworks and current legislation, it covers basic principles of bacteriology and virology, specific information on diseases and conditions, and material on 'hot topics' such as bioterrorism and preventative medicine.



Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides


Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-04-10

Complex Enzymes In Microbial Natural Product Biosynthesis Part A Overview Articles And Peptides written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-10 with Medical categories.


Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides Provides an extremely useful reference for the experienced research scientist



Prize Fight


Prize Fight
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Author : Morton Meyers, M.D.
language : en
Publisher: St. Martin's Press
Release Date : 2012-06-05

Prize Fight written by Morton Meyers, M.D. and has been published by St. Martin's Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Science categories.


We often think of scientists as dispassionate and detached, nobly laboring without any expectation of reward. But scientific research is much more complicated and messy than this ideal, and scientists can be torn by jealousy, impelled by a need for recognition, and subject to human vulnerability and fallibility. In Prize Fight , Emeritus Chair at SUNY School of Medicine Morton Meyers pulls back the curtain to reveal the dark side of scientific discovery. From allegations of stolen authorship to fabricated results and elaborate hoaxes, he shows us how too often brilliant minds are reduced to petty jealousies and promising careers cut short by disputes over authorship or fudged data. Prize Fight is a dramatic look at some of the most notable discoveries in science in recent years, from the discovery of insulin, which led to decades of infighting and even violence, to why the 2003 Nobel Prize in Medicine exposed how often scientific objectivity is imperiled.



Antibiotic Drug Resistance


Antibiotic Drug Resistance
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Author : José-Luis Capelo-Martínez
language : en
Publisher: John Wiley & Sons
Release Date : 2019-09-24

Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-24 with Medical categories.


This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies